Sodium butyrate improves the effects of brain injury in a small-for-gestational-age rat model by activating the JAK1/STAT3 pathway [0.03%]
丁酸钠通过激活JAK1/STAT3信号通路改善宫内生长受限大鼠脑损伤效应
Rui Zhang,Xiaona Chen,Qiuyue Shen et al.
Rui Zhang et al.
The mechanisms of cognitive impairment in small-for-gestational-age (SGA) infants remain unclear. We investigated clinical effects and mechanisms of sodium butyrate (NaB) treatment in a SGA rat model. Behavioral tests, immunohistochemistry,...
Knocking down RFWD3 suppresses the growth and migration of glioblastoma cells by blocking G2/M cycle progression [0.03%]
敲除RFWD3通过阻断G2/M周期进程抑制胶质母细胞瘤的生长和迁移
Zhongfei Hao,Yaming Han,Yunfei Bo et al.
Zhongfei Hao et al.
Glioblastoma (GBM) is the most common and lethal primary malignant tumor of the adult central nervous system, accounting for approximately half of all gliomas. Although RING finger and WD repeat domain 3 (RFWD3) has been implicated in the r...
IDH-wildtype astrocytoma with FH mutation, epigenetic similarity to IDH-mutant astrocytoma, and hypermethylation of CDKN2A arising in the brainstem [0.03%]
脑干室管膜下区域起源、表观遗传特征与异柠檬酸脱氢酶突变型星形细胞瘤相似、具FH突变的等柠檬酸脱氢酶野生型胶质瘤伴有CDKN2A高甲基化
Heather L Smith,Drew J Duckett,Melissa Mejia-Bautista et al.
Heather L Smith et al.
USP22 promotes neuroblastoma growth, metastasis, and glycolysis via mediating the deubiquitination of PDK1 [0.03%]
USP22通过促进PDK1去泛素化来促进神经母细胞瘤的生长、转移和糖酵解
Di Zhang,Ting Gu,Gengfei Cao et al.
Di Zhang et al.
Deubiquitinating enzymes are important regulators of cancer progression. We explored the role and regulatory mechanisms of the deubiquitinating enzyme ubiquitin-specific protease 22 (USP22) in neuroblastoma (NB). USP22 expression was upregu...
Spatially resolved transcriptomics reveals a unique disease signature and potential biomarkers for chronic traumatic encephalopathy [0.03%]
空间分辨转录组学揭示慢性创伤性脑病的独特疾病标志物和潜在生物标志物
Catherine M Suter,Jennifer E Cropley,Andrew J Affleck et al.
Catherine M Suter et al.
Chronic traumatic encephalopathy (CTE) is a poorly understood environmental tauopathy uniquely associated with repetitive head injury. It is clinically ambiguous and at present can only be diagnosed post-mortem. There is a pressing need to ...
FUS protein nuclear loss in skin biopsy: A window into the pathology and diagnosis of fused in sarcoma-associated amyotrophic lateral sclerosis [0.03%]
皮肤活检中的FUS蛋白核丢失：FS基因相关肌萎缩侧索硬化症病理和诊断的窗口
Didi Shan,Xiaohan Sun,Yao Tang et al.
Didi Shan et al.
Stereotactic lesioning of cholinergic cells by injection of ME20.4 Saporin in the nucleus basalis of Meynert in a rhesus monkey (Macaca mulatta) [0.03%]
靶向破坏猴大脑黑质胆碱能神经元的立体定位注射ME20.4-SAP法
Muhammad Nazmuddin,Marieke A Stammes,P Christiaan Klink et al.
Muhammad Nazmuddin et al.
Cholinergic degeneration in the nucleus basalis of Meynert (NBM) is clinically linked to cognitive impairment and gait dysfunction in Alzheimer's disease and Parkinson's disease. Modeling cholinergic degeneration in an animal model may prov...
Ependymal-like tumor with SMARCA2::PLAGL1 fusion: A novel molecular driver in neuroepithelial tumors with PLAGL1 fusion [0.03%]
SMARCA2::PLAGL1融合的类似ependymal肿瘤：神经上皮瘤中的一种新的分子驱动因素PLAGL1融合
John M Skaugen,Yitak M Lai,Joel C Rosenbaum et al.
John M Skaugen et al.
Cerebellopontine angle SHH-activated embryonal tumor without interaction from the cerebellum in a patient with Cowden syndrome: A case report [0.03%]
Cowden病患者的桥小脑角SHH活化胚胎性肿瘤病例报告（无小脑相互作用）
Takahiro Ishikawa,Kohei Fukuoka,Daiju Oba et al.
Takahiro Ishikawa et al.
Substance P-neurokinin 1 receptor signal involves the development of osteoarthritis-induced chronic pain in rats [0.03%]
补体系统参与急性应激所致抑郁样行为的神经机制研究
Minji Kwon,Taemin Kim,Eui Ho Park et al.
Minji Kwon et al.
Chronic pain is a major symptom of osteoarthritis (OA). Substance P (SP) plays a role in inflammation and nociception, but its role in OA pain chronicity remains unclear. This study investigates whether SP-neurokinin 1 (NK1R) signal mediate...