Downregulating Cdk5 reverses hippocampal neuron ferroptosis by regulating the AMP-activated protein kinase pathway and "M1" polarized microglia [0.03%]
下调Cdk5通过调节AMP活化蛋白激酶通路和“M1”极化小胶质细胞逆转海马神经元铁死亡
Na Liu,Aini Peng,Bo Peng et al.
Na Liu et al.
Aberrant activation of microglia plays a crucial role in neuronal injury after ischemic stroke. Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine-directed kinase that plays a significant role in neuronal damage. We investigated the rol...
Comparison of multiple quantitative strategies for neuropathologic image analyses [0.03%]
多种定量策略在神经病理图像分析中的比较研究
Hersh Kanner,Christopher Tilton,Victor E Alvarez et al.
Hersh Kanner et al.
The traditional semiquantitative (SQ) scoring system for neuropathologic assessment, although widely used, is prone to variability among assessors and does not capture the full spectrum of pathological changes. To address these limitations,...
METTL14/IGF2BP2-mediated m6A modification of PD-L1 promotes proliferation, metastasis, and immune escape in high-grade gliomas [0.03%]
METTL14/IGF2BP2介导的PD-L1m6A修饰促进高级别胶质瘤增殖、转移及免疫逃逸
Zexiang Zhang,Xiaoyu Guo,Tengfei Qi et al.
Zexiang Zhang et al.
N6-methyladenosine (m6A) RNA modification is involved in regulating the malignant progression and immune escape of glioblastoma multiforme (GBM). This study investigated the role of methyltransferase-like protein 14 (METTL14), the central c...
Thomas Auen,Jerrold Boxerman,Christine Z Yu et al.
Thomas Auen et al.
Proteasomal dysfunction in the mouse forebrain induces mitochondrial DNA release, cGAS-STING signaling activation, and necroptosis [0.03%]
小鼠前脑蛋白酶体功能障碍诱导线粒体DNA释放、cGAS-STING信号激活和坏死性凋亡
Abena Dwamena,Yasin Asadi,Erin Gilstrap et al.
Abena Dwamena et al.
Impaired proteasome function is associated with various neurodegenerative disorders that are hallmarked by neuroinflammation and neurodegeneration, including Alzheimer disease (AD); however, the relationships between these phenomena remain ...
Mevalonate kinase deficiency: Neuropathologic findings in an autopsy brain [0.03%]
甲戊酸激酶缺乏症的大脑尸检病理改变
Alexander Lokken,Eric Goold,Jessica M Comstock et al.
Alexander Lokken et al.
An autopsy case of facial-onset sensory and motor neuronopathy with central sleep apnea syndrome [0.03%]
面部起病感觉运动神经元病并发中枢性睡眠呼吸暂停综合征1例尸检报告
Asami Munekane,Taiji Nagai,Yuta Fukai et al.
Asami Munekane et al.
Autophagy impairment is associated with enhanced satellite cell activation in muscle biopsies from younger late-onset Pompe disease patients [0.03%]
自噬功能障碍与年轻晚发型庞贝病患者的肌肉活检中卫星细胞激活增强有关
Gianmarco Severa,Sultan Bastu,Giovanni Umberto Borin et al.
Gianmarco Severa et al.
Late-onset Pompe disease (LOPD) is caused by α-glucosidase (GAA) deficiency, leading to glycogen accumulation resulting in progressive muscular weakness and respiratory insufficiency. Glycogen overload, vacuolation, and autophagic accumula...
Lesion level and severity acutely influence metabolomic profiles in spinal cord injury [0.03%]
损伤水平和程度急性影响脊髓损伤的代谢组学谱型
Abi G Yates,Steven Dierksmeier,Yvonne Couch et al.
Abi G Yates et al.
Changes in the peripheral metabolome, particularly in the blood, may provide biomarkers for assessing lesion severity and predicting outcomes after spinal cord injury (SCI). Using principal component analysis (PCA) and Orthogonal Partial Le...
Grace K Grafham,Gloria Mak,Sandra Grant et al.
Grace K Grafham et al.
Amyloidosis is an etiologically heterogeneous group of disorders pathologically characterized by the extracellular deposition of amyloid fibrils, leading to tissue damage. It commonly affects the peripheral nervous system and occasionally i...