Diffuse leptomeningeal glioneuronal tumour in the elderly: A molecularly confirmed case with loss of H3 K27me3 and pTERT mutation [0.03%]
老年弥散性脑膜神经胶质瘤的分子改变特征：H3K27me3缺失和pTERT突变的病例报道
Marcella Callea,Rosina Paterra,Luisa Maddaloni et al.
Marcella Callea et al.
Cross-talk between pyroptosis and miRNAs in Alzheimer disease neuropathology, therapeutic targeting of NLRP inflammasomes, and recent advances in nanoparticle-targeted therapy [0.03%]
阿尔茨海默病神经病理中焦亡与miRNA之间的串扰、NLRP炎症小体的治疗靶向及纳米颗粒靶向治疗的最新进展
Hebatallah M Saad,Esraa Atef,Asmaa A Aboushouk et al.
Hebatallah M Saad et al.
Alzheimer disease (AD) is a widespread neurodegenerative disorder. It is pathologically marked by the deposition of β-amyloid (Aβ) plaques and a high phosphorylation level of tau proteins, resulting in neurofibrillary tangle development, ...
Quantification of Ki-67 labeling index in pediatric brain tumor immunohistochemistry images [0.03%]
儿科脑肿瘤免疫组化图像中Ki-67标记指数的量化分析方法研究
Christoforos Spyretos,Juan Manuel Pardo Ladino,Hakon Andersen Blomstrand et al.
Christoforos Spyretos et al.
Quantification of the Kiel 67 (Ki-67) labeling index (LI) is critical for assessing proliferation and prognosis in tumors but manual scoring remains a common practice. We present an automated framework for Ki-67 scoring in whole slide image...
Clinical and pathologic correlations of machine learning quantification of Aβ deposits across 3 brain regions of decedents with Alzheimer disease [0.03%]
阿尔茨海默病死者大脑3个脑区Aβ沉积的机器学习量化与其临床和病理的相关性
David Garcia,Shivam Rajendra Rai Sharma,Naomi Saito et al.
David Garcia et al.
Machine learning enables scalable quantification of neuropathology, offering deeper phenotyping of Alzheimer's disease (AD). In this validation study, we quantified amyloid-beta (Aβ) deposits, evaluating multiple brain regions across insti...
Association of CDKN2A/B and MTAP deletions in adult-type diffuse gliomas [0.03%]
成人型弥漫性胶质瘤中CDKN2A/B和MTAP的缺失之间的关联
Blake A Ebner,Cristiane M Ida,Thomas M Kollmeyer et al.
Blake A Ebner et al.
In adult-type diffuse gliomas CDKN2A and/or CDKN2B (CDKN2A/B) deletions often co-occur with deletion of MTAP, suggesting that MTAP immunohistochemistry (IHC) may be a surrogate marker of CDKN2A/B status. However, the association between CDK...
Eleanor Clifton-Bligh,Andrew J Affleck,Jennifer E Cropley et al.
Eleanor Clifton-Bligh et al.
Azetidine-2-carboxylic acid-induced oligodendrogliopathy in vitro and the pathogenesis of multiple sclerosis [0.03%]
乙内酰脲-2-羧酸诱发的少突胶质细胞损伤及多发性硬化的发病机理
Raymond A Sobel,Julian R Hinojoza,Muhammad Zoabi
Raymond A Sobel
Azetidine 2-carboxylic acid (Aze) is consumed by humans and can be misincorporated in place of proline (Pro) in myelin basic protein (MBP). In systemically treated mice Aze induced distinct oligodendroglial (OL) alterations mimicking those ...
Methyltransferase-like protein 16 suppresses spinal cord injury by regulating microglia polarization via N6-methyladenosine-modified downregulation of MCEMP1 [0.03%]
甲基转移酶样蛋白16通过N6-甲基腺苷修饰的MCEMP1下调调节小胶质细胞极化抑制脊髓损伤
Lei Zhang,Haijun Chang,Guangming Jiang et al.
Lei Zhang et al.
N6-methyladenosine (m6A) modification is a prevalent epigenetic mechanism influencing spinal cord injury (SCI) progression. Methyltransferase-like protein 16 (METTL16) plays crucial roles in various diseases. However, its specific function ...
Zachary L Morcos,Theoharis C Theoharides
Zachary L Morcos
Postacute sequelae of SARS-CoV-2 infection (PASC), or Long COVID, is estimated to affect over 60 million individuals globally, with almost half of COVID-19 survivors experiencing persistent symptoms such as neuropathic pain, fatigue, and au...
Intracranial solitary fibrous tumor with myxoid features: An unusual presentation [0.03%]
具有黏液样特征的颅内孤立性纤维瘤：不寻常的表现形式
Anna Vi Jones,M Beatriz S Lopes,Sohil H Patel et al.
Anna Vi Jones et al.