Neuroprotective effects of estradiol and progesterone against hypoxia-induced apoptosis in mouse primary cortical neurons [0.03%]
雌二醇和孕酮对小鼠皮层神经元缺氧诱导的凋亡的神经保护作用
Abolfazl Azami Tameh,Javad Amini Mahabadi,Mohammad Ali Atlasi et al.
Abolfazl Azami Tameh et al.
Hypoxia leads to neuronal damage and 17β-estradiol (E2) and progesterone (P4) exhibit neuroprotective properties in such conditions. However, the precise mechanisms behind these effects remain unexplored. This study evaluates the neuroprot...
Mitochondrial dysfunction and its impact on pyroptosis and ferroptosis cross talk in glioma cells [0.03%]
线粒体功能障碍及其对胶质瘤细胞焦亡和铁死亡的串扰影响
Yunzhu Guo,Hang Liu,Ziqi Gao et al.
Yunzhu Guo et al.
Glioblastomas (GBM), the most aggressive primary brain tumors, remain challenging to treat due to their rapid proliferation, invasiveness, and resistance to current therapies. Emerging evidence highlights pyroptosis and ferroptosis as criti...
Activated signaling pathways and metabolic processes in disseminating myxoid glioneuronal tumors [0.03%]
播散性黏液样胶质神经细胞瘤的活化信号通路和代谢过程
William Y Chiang,Xiaoyu Li,Ryuma Tanaka et al.
William Y Chiang et al.
Myxoid glioneuronal tumor (MGNT) is a recently recognized rare neural tumor in the 2021 WHO Classification of CNS Tumors. Myxoid glioneuronal tumor has low-grade histology and a generally good overall survival rate. However, some tumors exh...
Convolutional neural network-derived neurofibrillary tangle classifiers: Investigative tools to identify maturation levels and explore post-translational modifications using laser capture microdissection coupled mass spectrometry [0.03%]
基于卷积神经网络的神经原纤维缠结分类器：利用激光捕获微解剖与质谱技术识别成熟阶段和探索翻译后修饰的研究工具
Couger Jimenez Jaramillo,Drew Nedderman,Erpan Ahat et al.
Couger Jimenez Jaramillo et al.
Post-translational modifications (PTM) of tau are implicated in Alzheimer disease (AD) progression and are established biomarkers in cerebrospinal fluid and plasma; however, the labor-intensive nature of conventional proteomics limits their...
Increased efficacy of adipose-derived mesenchymal stem cells transduced with klotho in differentiation and maturation of oligodendrocytes in a mouse model of experimental autoimmune encephalomyelitis [0.03%]
经Klotho转导的脂肪源性间充质干细胞在实验性自身免疫性脑脊髓炎小鼠模型少突胶质细胞分化成熟中功效增强
Maryam Rezapour Kalkhoran,Narges Maleki,Fatemeh Rahbarizadeh et al.
Maryam Rezapour Kalkhoran et al.
Current therapies for multiple sclerosis (MS) exert immunomodulatory effects but do not directly repair central nervous system (CNS) damage. Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic strategy for MS, as they have...
Yoshitaka Mizushima,Kohei Fukuoka,Kayoko Ichimura et al.
Yoshitaka Mizushima et al.
A fixed brain seeded amplification assay to complement neuropathological prion disease diagnosis [0.03%]
一种固定脑种子增殖实验用于补充神经病理异常小鼠海马牙冠的克雅氏病诊断
Victoria Lewis,Laura Ellett,Enie Lei et al.
Victoria Lewis et al.
Prion diseases are rare neurodegenerative disorders that share misfolding of the normal cellular prion protein into disease-causing isoforms known as "prions" as the critical pathophysiological event. Definite diagnosis can only be achieved...
3D spatial sampling to quantify morphologic heterogeneity in isocitrate dehydrogenase-wildtype glioblastoma [0.03%]
三维空间取样量化异柠檬酸脱氢酶野生型胶质母细胞瘤形态学异质性
Viva Voong,Sol Beccari,Elaheh Hashemi et al.
Viva Voong et al.
Advances in digital pathology and machine learning have the potential to revolutionize diagnostic neuropathology. Current brain tumor models are typically trained and validated using morphologic features from a single hematoxylin and eosin ...
Neuropathologic findings in a community-based autopsy cohort of older, virally suppressed, people with HIV [0.03%]
来自社区尸检队列的老年病毒抑制HIV患者的神经病理学发现
Thomas D Zaikos,Haidan Guo,Alex Barrett et al.
Thomas D Zaikos et al.
Combination antiretroviral therapy (cART) has reduced the incidence of HIV-related mortality, leading to a growing population of older virally suppressed people with HIV (PWH). cART has also decreased the prevalence of HIV-associated dement...
Desmoplastic myxoid tumor of the pineal region presenting with Parinaud syndrome [0.03%]
松果体区粘液样肌成纤维细胞肿瘤伴Parinaud综合征一例报告
Tal Jonatan Koren,Michael Back,Jason Chen et al.
Tal Jonatan Koren et al.