A pediatric case of YAP1::MAML2 fusion-positive supratentorial ependymoma: A potential subtype of YAP1-fused ependymoma [0.03%]
YAP1::MAML2融合阳性幕上室管膜瘤一例：YAP1重排型室管膜瘤的新亚型？
Kento Kawata,Ryuma Tanaka,Kohei Fukuoka et al.
Kento Kawata et al.
The NORAD-Pumilio regulatory axis in the evolution of inclusion body myositis [0.03%]
NORAD-Pumilio调控轴在包涵体肌炎进化中的作用
Lingying Tong,Burcak Ozes,Kyle Moss et al.
Lingying Tong et al.
Sporadic inclusion body myopathy (sIBM) is the most common progressive degenerative skeletal muscle disease of older people with poorly understood pathogenesis. We assessed the involvement and impact of the noncoding RNA activated by DNA da...
Vascular burden attenuates the TDP-43-TMEM106B pathological relationship in neurodegenerative disease with and without Alzheimer disease neuropathological change [0.03%]
血管负担减弱了TDP-43-TMEM106B病理关系在有和无阿尔茨海默病神经病理改变的神经退行性疾病中的作用
Matthew B Dopler,Cole Corbett,Angelique D Gonzalez et al.
Matthew B Dopler et al.
TMEM106B, a lysosomal transmembrane protein, is a risk factor for neurodegenerative diseases, including Alzheimer disease (ad) and TDP-43 proteinopathies. TMEM106B pathology occurs in normal aging and is increased in TDP-43 proteinopathy bu...
C5aR antagonism by PMX205 confers neuroprotection in hypoxic-ischemic brain injury models via anti-inflammatory and anti-apoptotic mechanisms [0.03%]
缺血性脑损伤模型中，PMX205通过抗炎和抗凋亡机制拮抗C5a受体以实现神经保护作用
Chengjiao Huang,Sang Shang,Yulian Hu et al.
Chengjiao Huang et al.
Hypoxic-ischemic brain injury (HIBI) is a major contributor to poor neurological outcomes after cardiac arrest. The complement C5a-C5aR axis has been implicated in ischemic neuronal damage. This study investigated the neuroprotective effect...
Comparison of the effects of intensities and sessions of extracorporeal shock wave therapy on nerve regeneration in rats with experimentally induced sciatic nerve injury [0.03%]
不同强度及次数体外冲击波治疗对实验性坐骨神经损伤大鼠神经再生的影响比较研究
Tae Heon Lee,Dongho Lee,Minsu Seo et al.
Tae Heon Lee et al.
Extracorporeal shock wave therapy (ESWT) has emerged as a promising treatment for neurological disorders but optimal protocols regarding energy density and session frequency remain unclear. This study aimed to evaluate the effects of differ...
Relationship between promyelocytic leukemia protein nuclear bodies and TAR DNA-binding protein-43 aggregation in spinal anterior horn cells in sporadic amyotrophic lateral sclerosis [0.03%]
散发性肌萎缩侧索硬化症患者脊髓前角细胞中早老素蛋白白血病核体与TARDNA结合蛋白43聚集的关系
Fumiaki Mori,Tomoya Kon,Riho Itazawa et al.
Fumiaki Mori et al.
Promyelocytic leukemia protein nuclear bodies (PML-NBs) and stress granules serve as deposition sites for stress-induced, aggregation-prone proteins. We previously reported that TAR DNA-binding protein 43 (TDP-43) colocalizes with stress gr...
RagC and Map4K3 deficiency in high-grade gliomas drives proliferation and modulates mTORC1-dependent cellular functions [0.03%]
胶质瘤中RagC和Map4K3缺陷促进增殖并调节mTORC1依赖性细胞功能
Julian Kahr,Roberto Diaz-Peregrino,Ibrahim E Sandalcioglu et al.
Julian Kahr et al.
Cellular growth and homeostasis via amino acid-responsive pathways are mediated by the mTOR signaling pathway. Rag GTPases and Map4K3 modify mTOR signaling as amino acid sensors. Altered mTOR signaling in relation to amino acid sensors migh...
Terminal presentation and postmortem diagnosis of a mesenchymal chondrosarcoma with extensive intracranial involvement [0.03%]
广泛累及颅内的间叶性软骨肉瘤的终末期临床表现和尸检诊断
Jane E Persons,Kathryn L Eschbacher,Megan I Samuelson et al.
Jane E Persons et al.
Reduced nuclear TDP-43 and cytoplasmic DLK1 as markers of motor neuron degeneration in amyotrophic lateral sclerosis [0.03%]
核TDP-43减少和细胞质DLK1作为肌萎缩侧索硬化运动神经元变性的标志物
Takahiro Takeda,Ai Ishikawa,Sayuri Kokubun et al.
Takahiro Takeda et al.
Loss of upper and lower motor neurons (MNs) is a defining pathological feature underlying the clinical manifestations of amyotrophic lateral sclerosis (ALS). However, the differences in MN loss and TDP-43 pathology between these areas in AL...