Leucine-rich pentatricopeptide repeat-containing protein silencing transcriptionally regulated by GATA-binding protein 3 has an anti-glioma effect by regulating glycolysis and ferroptosis by mediating N6-methyladenosine modification of protocadherin-7 [0.03%]
富含亮氨酸的五聚三联肽重复序列阴性调节子GATA结合蛋白3通过介导原钙粘素7的N6-甲基腺苷修饰对胶质瘤发挥抑瘤作用
Yong Sun,Yunlong Jia,Xingyao Bu et al.
Yong Sun et al.
Leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) is a recently identified N6-methyladenosine (m6A) reader protein involved in a myriad of biological processes in cancer. However, its roles in glioma have not been reported. ...
Chronic traumatic encephalopathy neuropathologic change is associated with highest stage limbic-predominant age-related TDP-43 encephalopathy [0.03%]
慢性创伤性脑病的神经病理改变与最高阶段以边缘通路为主的老年期TDP-43脑病相关
Hailong Song,Kamar E Ameen-Ali,Claire Kennedy-Dietrich et al.
Hailong Song et al.
Traumatic brain injury (TBI) is recognized as a major risk factor for neurodegenerative disease (NDD). Autopsy studies frequently describe chronic traumatic encephalopathy neuropathologic change (CTE-NC) in individuals with histories of rep...
Effects of concurrent neuropathologies with Alzheimer disease neuropathologic change on cognitive decline: Minimal impact of vascular brain injury compared with other combinations [0.03%]
阿尔茨海默病病变与其他神经病理变化(与脑血管损伤相比)共同作用对认知衰退的影响：脑血管损伤的效应最小
Sarah M Yasuda,Charles Mock,Kathryn Gauthreaux et al.
Sarah M Yasuda et al.
We examined cognitive changes associated with several neuropathologic entities, alone and in combination. We studied 808 participants from the National Alzheimer's Coordinating Center to assess associations between neuropathologic diagnoses...
The N6-methyladenosine (m6A) reader YTHDF3 increases PINK1/Parkin-mediated mitophagy by facilitating prohibitin 2 (PHB2) translation to promote retinal ganglion cell damage in diabetic retinopathy [0.03%]
N6-甲基腺苷（m6A）阅读器YTHDF3通过促进PHB2翻译来增强PINK1/Parkin介导的线粒体自噬以促进糖尿病视网膜病变中的视网膜神经节细胞损伤
Zeyi Lv,Peilin Lv,Long Pang et al.
Zeyi Lv et al.
Retinal ganglion cells (RGCs) are particularly vulnerable to damage during the early stages of diabetic retinopathy (DR). Emerging evidence indicates that dysregulated expression of N6-methyladenosine (m6A) methylation regulators contribute...
Atherogenic-like lesions associated with a progressive chronic vascular degeneration in a rat model of repetitive low-level blast brain injury [0.03%]
重复低水平爆炸脑损伤大鼠模型中的动脉硬化病变与进行性慢性血管退行性变相关
Miguel A Gama Sosa,Rita De Gasperi,Rachel H Lind et al.
Miguel A Gama Sosa et al.
Repetitive low-level blast exposures in rats induce the development of a post-traumatic stress disorder (PTSD)-like phenotype and evolving chronic brain vascular alterations. These alterations included atherogenic-like lesions characterized...
Blocking FOXO4 confers neuroprotection against oxidative stress and ischemia-reperfusion caused neuronal injury [0.03%]
FOXO4信号通路在脑缺血再灌注损伤及氧化应激诱导的神经元损伤中的作用及机制研究
Yasin Asadi,Anand Chakroborty,Farhad Gorjipour et al.
Yasin Asadi et al.
Previous studies suggest that FOXO4 facilitates inflammation and oxidative stress in non-brain tissues under stress or disease conditions, indicating that downregulation of FOXO4 may be neuroprotective in ischemia-reperfusion-induced brain ...
Alzheimer neuropathological change, α-synuclein and transactive response DNA-binding protein of 43 kDa expression in children and young adult brains from forensic autopsies: Value for early measurement of abnormal protein expression prevalence in neurodegenerative diseases [0.03%]
阿尔茨海默病神经病理改变、α-突触核蛋白和43kDa转化生长因子响应DNA结合蛋白在法医尸检儿童及年轻人脑中的表达：对神经退行性疾病异常蛋白表达流行率的早期测量的价值
Lilian Calderón-Garcidueñas,Ozkan Ufuk Nalbantoglu,Angélica González-Maciel et al.
Lilian Calderón-Garcidueñas et al.
Alzheimer disease (AD) neuropathologic change (ADNPC), Parkinson disease (PD) α-synuclein (α-Syn), and TAR DNA-binding protein 43 (TDP-43) pathology overlap in a continuum in fine particulate matter (PM2.5)-exposed Metropolitan Mexico Cit...
Locus coeruleus TDP-43 pathology in a community-based cohort: Clinical and pathological correlates [0.03%]
基于社区的队列中蓝斑TDP-43病理改变的临床和病理特征
Allison M Neltner,Ryan K Shahidehpour,Megan E Hall et al.
Allison M Neltner et al.
The locus coeruleus (LC) is the source of norepinephrinergic innervation in the human brain. Locus coeruleus pathology has been linked to clinical conditions such as cognitive impairment and behavioral and psychiatric symptoms of dementia (...
Morroniside maintains mitochondrial homeostasis in microglia and mitigates neuroinflammation in experimental autoimmune encephalomyelitis [0.03%]
莫诺苷维持少突胶质细胞中微胶质线粒体稳态，并缓解实验性自身免疫性脑脊髓炎中的神经炎症
Shaopeng Zhai,Taotao Jiang,Xiaorong Cheng et al.
Shaopeng Zhai et al.
Microglia-mediated neuroinflammation in the central nervous system is a hallmark of both multiple sclerosis (MS) and the animal model experimental autoimmune encephalomyelitis (EAE). Current immunosuppressive therapies for MS have limited e...
Localization of mast cells in human brain tissue: Implications for neuropsychiatric symptoms in COVID-19 [0.03%]
人脑组织中肥大细胞的定位：对新冠肺炎神经精神症状的意义
Jennifer Nicoloro-SantaBarbara,Matthew P Giannetti,Isaac H Solomon et al.
Jennifer Nicoloro-SantaBarbara et al.