Multisite study: Predicting Lewy body disease using skin biopsy α-synuclein seed amplification assays [0.03%]
多中心研究：利用皮肤活检α-突触核蛋白种子增殖试验预测路易体疾病
Chelva Janarthanam,Christina D Orrú,Andrew G Hughson et al.
Chelva Janarthanam et al.
Skin biopsies analyzed with α-synuclein seed amplification assays (SAAs) are a simple way to clinically interrogate the presence of α-synuclein aggregates. We determined the accuracy of skin biopsy SAA in predicting the clinical diagnoses...
Histopathological and molecular heterogeneity of dysembryoplastic neuroepithelial tumors [0.03%]
发育不良神经上皮瘤的病理和分子异质性
Yuxiu Wang,Sarra Belakhoua,Yiying Yang et al.
Yuxiu Wang et al.
Dysembryoplastic neuroepithelial tumors (DNTs) are low-grade glioneuronal tumors with FGFR1 alterations. They show significant histologic and molecular overlap with other glioneuronal tumors, complicating diagnosis. We analyzed 44 tumors th...
Comorbid neuropathologies but not Braak stage influence cognitive impairment in primary age-related tauopathy [0.03%]
伴发神经病理改变而非Braak分期影响primary age-related tauopathy患者的认知损害
Shrishtee Kandoi,Satomi Hiya,Carolina Maldonado-Díaz et al.
Shrishtee Kandoi et al.
Primary age-related tauopathy (PART) is a β-amyloid-independent tauopathy, thought by some to be a distinct process from Alzheimer disease neuropathologic change (ADNC). Two categories of PART have been defined: definite PART (those with c...
Secondary atypical teratoid/rhabdoid tumors are not necessarily categorized as AT/RT by DNA methylation analysis [0.03%]
二次异位性/肉瘤样脑肿瘤不一定是DNA甲基化分析中的AT/RT型
Haruna Okuno,Kohei Fukuoka,Keishiro Amano et al.
Haruna Okuno et al.
GRN rs5848 variant associates with TDP-43 pathology and cancer in opposite directions [0.03%]
GRN rs5848变异以相反方向与TDP-43病理和癌症相关
Khine Zin Aung,Peter T Nelson,Xiaotong Ning et al.
Khine Zin Aung et al.
Epidemiologic studies have reported that cancer survivors have a relatively low risk of developing dementia, but the mechanisms underlying that inverse relationship are mostly unknown. The Granulin (GRN) gene single nucleotide variant rs584...
Cortical subpial aging-related tau astrogliopathy in older adult men who participated in youth amateur American-style football [0.03%]
参与过美式橄榄球运动的老年男性的皮层下Tau星形胶质细胞病理性改变
Grant L Iverson,Pouya Jamshidi,Amy Deep-Soboslay et al.
Grant L Iverson et al.
Astrocytes play essential roles in various functions including ionic homeostasis, energy metabolism, neurotransmission, and regulation of the blood-brain barrier. Researchers have reported that hyperphosphorylated tau in astrocytes can be i...
Effects of phytocannabinoids, synthetic and semi-synthetic cannabinoids on microglia and astrocytes: Review of neuroinflammatory mechanisms [0.03%]
植物类大麻素、合成和半合成大麻素对小胶质细胞和星形胶质细胞的作用：神经炎症机制综述
Giulia Brambilla,Giacomo Belli,Andrea Paggi et al.
Giulia Brambilla et al.
Over 120 phytocannabinoids and 190 synthetic and semi-synthetic cannabinoids have been identified. Many of these currently circulate in recreational and illicit drug markets. Epidemiological evidence indicates a progressive increase in thei...
Atorvastatin and ischemic stroke: Mechanisms and therapeutic applications [0.03%]
阿托伐他汀与缺血性卒中：机制和治疗应用
Peyman Esmaili-Shahzade-Ali-Akbari,Abolfazl Azami Tameh,Houman Parsaei et al.
Peyman Esmaili-Shahzade-Ali-Akbari et al.
Stroke is a leading cause of death and disability, affecting approximately 13.7 million people worldwide and causing 5.5 million deaths annually. Effective treatment options for ischemic stroke are still limited and existing clinical interv...