Elena V Daoud,Megan Wachsmann,Timothy E Richardson et al.
Elena V Daoud et al.
Pleomorphic xanthoastrocytoma (PXA) is a slow-growing neoplasm that predominantly affects the pediatric and young adult population. This neoplasm has a good prognosis, with a median 10-year survival rate of 70%. The majority of tumors are s...
Noninvasive, Targeted Creation of Neuromyelitis Optica Pathology in AQP4-IgG Seropositive Rats by Pulsed Focused Ultrasound [0.03%]
脉冲聚焦超声技术在AQP4-IgG阳性大鼠中无创靶向构建视神经脊髓炎病理损害模型
Xiaoming Yao,Matthew S Adams,Peter D Jones et al.
Xiaoming Yao et al.
Neuromyelitis optica spectrum disorders (herein called NMO) is an autoimmune disease of the CNS characterized by astrocyte injury, inflammation, and demyelination. In seropositive NMO, immunoglobulin G autoantibodies against aquaporin-4 (AQ...
Eric S Lipp,Patrick Healy,Alan Austin et al.
Eric S Lipp et al.
Glioma therapeutic resistance to alkylating chemotherapy is mediated via O6-methylguanine-DNA methyltransferase (MGMT). We hypothesized that a CD45/HAM56/MGMT double-stained cocktail would improve MGMT discrimination in tumor cells versus i...
Divergent Features of Mitochondrial Deficiencies in LGMD2A Associated With Novel Calpain-3 Mutations [0.03%]
与新型calpain-3突变相关的LGMD2A的线粒体缺陷的发散特征
Riyad El-Khoury,Sahar Traboulsi,Tarek Hamad et al.
Riyad El-Khoury et al.
Limb girdle muscular dystrophy type 2A (LGMD2A) is an autosomal recessive disorder characterized by progressive muscle weakness and wasting. LGMD2A is caused by mutations in the calpain-3 gene (CAPN3) that encodes a Ca2+-dependent cysteine ...
SIV-Induced Immune Activation and Metabolic Alterations in the Dorsal Root Ganglia During Acute Infection [0.03%]
急性感染期间SIV诱导的免疫活化和背根神经节中的代谢改变
Lisa M Mangus,Rachel L Weinberg,Audrey C Knight et al.
Lisa M Mangus et al.
Human immunodeficiency virus-associated sensory neuropathy (HIV-SN) remains a frequent neurologic complication of HIV infection. Little is known about alterations in the peripheral nervous system during the early stages of HIV, a time when ...
Blood Vessels and Perivascular Phagocytes of Prefrontal White and Gray Matter in Suicide [0.03%]
与自杀相关的额叶白质和灰质血管及血管周巨噬细胞的研究
Tatiana P Schnieder,Isaiah D Zhou Qin,Iskra Trencevska-Ivanovska et al.
Tatiana P Schnieder et al.
Inflammatory processes may contribute to psychiatric disorders and suicide. Earlier, we reported greater densities of perivascular phagocytes in dorsal prefrontal white matter (DPFWM) in suicide than in non-suicide deaths. To distinguish be...
Combined Adipose-Derived Mesenchymal Stem Cells and Low-Energy Extracorporeal Shock Wave Therapy Protect the Brain From Brain Death-Induced Injury in Rat [0.03%]
联合应用脂肪源性间充质干细胞和低强度体外冲击波治疗预防脑死亡大鼠脑损伤
Kuan-Hung Chen,Hao-Yi Hsiao,Christopher Glenn Wallace et al.
Kuan-Hung Chen et al.
This study tested the hypothesis that combined adipose-derived mesenchymal stem cell (ADMSC) and low-energy extracorporeal shock wave (ECSW) therapy could protect brain from brain death (BD)-induced injury. Adult male Sprague Dawley rats we...
Sarcolemmal Complement Membrane Attack Complex Deposits During Acute Rejection of Myofibers in Nonhuman Primates [0.03%]
非人灵长类急性心肌移植物排斥反应时的横纹肌丝和肌膜补体沉积
Daniel Skuk,Jacques P Tremblay
Daniel Skuk
We have previously studied in nonhuman primates several aspects of the acute rejection of myofibers, including the histological characteristics, the mechanisms of myofiber elimination by the T cells, and the development of anti-donor antibo...
Quantitative Assessment of Pathological Tau Burden in Essential Tremor: A Postmortem Study [0.03%]
原发性震颤患者tau蛋白病理负担的量化分析：一项尸检研究
Kurt Farrell,Stephanie Cosentino,Megan A Iida et al.
Kurt Farrell et al.
Essential tremor (ET) patients develop more cognitive impairment and dementia than controls, although there are surprisingly few data on the neuropathological basis for cognitive changes in ET. In this postmortem study, we assessed tau and ...
Severe TUBB4A-Related Hypomyelination With Atrophy of the Basal Ganglia and Cerebellum: Novel Neuropathological Findings [0.03%]
严重TUBB4A相关低髓鞘病变伴基底节和小脑萎缩：新型神经病理发现
Kristina M Joyal,Jean Michaud,Marjo S van der Knaap et al.
Kristina M Joyal et al.
Hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC) is a rare hypomyelinating leukodystrophy characterized by infantile or childhood onset of motor developmental delay, progressive rigidity and spasticity, with hypomyel...