Beuy Joob,Viroj Wiwanitkit
Beuy Joob
Brian S Appleby,Daniel D Rhoads,Karin Mente et al.
Brian S Appleby et al.
Prion diseases comprise a group of transmissible degenerative encephalopathies resulting from propagation of a misfolded cellular protein of uncertain function. As is generally the case with rare diseases, lack of institutional experience c...
Tamar Gefen,Saman S Ahmadian,Qinwen Mao et al.
Tamar Gefen et al.
This study investigated the presence of combined pathologies in a large cohort of autopsies that show a primary pathologic diagnosis of phosphorylated 43-kDa TAR DNA-binding protein (FTLD-TDP), the majority of which portrayed clinical pheno...
Comparative Cytogenetic Analysis of Dog and Human Choroid Plexus Tumors Defines Syntenic Regions of Genomic Loss [0.03%]
对狗和人类脉络丛肿瘤的比较细胞遗传学分析界定了基因组丢失的同线性区域
Devin Ancona,Dan York,Robert J Higgins et al.
Devin Ancona et al.
Choroid plexus tumors (CPTs) occur spontaneously in humans and dogs providing an opportunity for comparative cross species analysis of common tumor mechanisms. Large scale chromosomal copy number alterations are the hallmark of human CPTs a...
Postmortem Histopathologic Analysis of Neurosyphilis: A Report of 3 Cases With Clinicopathologic Correlations [0.03%]
神经梅毒的尸体解剖病理分析：3例临床与病理的相关性报告
Chenhui Mao,Jing Gao,Liri Jin et al.
Chenhui Mao et al.
Neurosyphilis occurs in the late stage of systemic syphilis infection; early diagnosis and treatment are crucial to the prognosis. We review 3 autopsy cases with different subtypes of neurosyphilis, that is cases with meningovascular, gener...
Revisiting Pathological Classification Criteria for Adult Idiopathic Inflammatory Myopathies: In-Depth Analysis of Muscle Biopsies and Correlation Between Pathological Diagnosis and Clinical Manifestations [0.03%]
成人特发性炎性肌病病理分类标准的再评价：肌肉活检的深入分析及病理诊断与临床表现的相关性研究
Ying Hou,Yue-Bei Luo,Tingjun Dai et al.
Ying Hou et al.
The European Neuromuscular Centre (ENMC) pathological classification criteria of idiopathic inflammatory myopathies (IIMs) are debatable. The aim of this study was to explore their practicability and reproducibility. We conducted a retrospe...
GSK-3β/mTORC1 Couples Synaptogenesis and Axonal Repair to Reduce Hypoxia Ischemia-Mediated Brain Injury in Neonatal Rats [0.03%]
GSK-3β/mTORC1信号通路通过促进新生大鼠缺氧缺血后突触发生和轴突修复减少脑损伤
Tao Xiong,Yi Qu,Huiqin Wang et al.
Tao Xiong et al.
Glycogen synthase kinase 3 beta (GSK-3β) plays an important role in neurological outcomes after brain injury. However, its roles and mechanisms in hypoxia-ischemia (HI) are unclear. Activation of mTOR complex 1 (mTORC1) has been proven to ...
INSM1 Expression Is Frequent in Primary Central Nervous System Neoplasms but Not in the Adult Brain Parenchyma [0.03%]
中枢神经系统原发性肿瘤而非成人脑实质表达INSM1蛋白质
Heather M Ames,Lisa M Rooper,John J Laterra et al.
Heather M Ames et al.
Tumors with a neuronal component comprise a small percentage of central nervous system (CNS) neoplasms overall, but the presence of neuronal differentiation has important diagnostic, prognostic, and therapeutic implications. Insulinoma-asso...
Leptomeninges-Derived Induced Pluripotent Stem Cells and Directly Converted Neurons From Autopsy Cases With Varying Neuropathologic Backgrounds [0.03%]
不同神经病理背景的死后病例衍生的脑室管膜细胞来源的诱导多能干细胞和直接重编程的神经元
Shannon E Rose,Harald Frankowski,Allison Knupp et al.
Shannon E Rose et al.
Patient-specific stem cell technology from skin and other biopsy sources has transformed in vitro models of neurodegenerative disease, permitting interrogation of the effects of complex human genetics on neurotoxicity. However, the neuropat...
Martin Hasselblatt,Mohammed Jaber,David Reuss et al.
Martin Hasselblatt et al.
The histological and molecular features and even the mere existence of diffuse astrocytoma, IDH-wildtype, remain unclear. We therefore examined 212 diffuse astrocytomas (grade II WHO) in adults using IDH1(R132H) immunohistochemistry followe...