The association between virus-induced spinal cord pathology and the genetic background of the host [0.03%]
病毒诱发的脊髓病变与宿主遗传背景的关系探究
Koedi S Lawley,Tae Wook Kang,Raquel R Rech et al.
Koedi S Lawley et al.
Theiler's murine encephalomyelitis virus (TMEV) infection in mice has been used to study diverse neurological diseases, including multiple sclerosis and epilepsy. In this investigation, 5 strains of collaborative cross (CC) mice were infect...
Phosphorylated tau aggregation in the brains of aged Artiodactyla animals [0.03%]
蹄纲动物脑中磷酸化tau聚集现象及其与年龄的关系研究
Yutaro Nakayama,James K Chambers,Kazuyuki Uchida
Yutaro Nakayama
The aggregation of amyloid-β (Aβ) and phosphorylated tau (p-tau) in the human brain is associated with Alzheimer disease (AD). Although Aβ aggregation has been reported in various mammals, significant p-tau aggregation has been reported ...
Muscle mitochondrial changes in antisynthetase syndrome and other idiopathic inflammatory myopathies [0.03%]
抗氨酰-tRNA合成酶综合征及其他特发性炎性肌病的肌肉线粒体改变
Alison Murphy,Gloria Mak,Katerina Gordon et al.
Alison Murphy et al.
Mitochondria are critical for cellular function. Their dysfunction contributes to cell degeneration and death, leading to disease progression. This study examined mitochondrial changes in idiopathic inflammatory myopathies (IIMs) including ...
Fumarate hydratase-mutant glioma with giant-cell histology, MSH6 mutation, and hypermutation [0.03%]
富马酸水合酶突变型胶质瘤的巨细胞组织学、MSH6突变和高突变率
Andrea Mafficini,Filippo Pigato,Evelina Miele et al.
Andrea Mafficini et al.
RECQL4 alterations in gliomas and nerve sheath tumors: Expression patterns and therapeutic implications [0.03%]
胶质瘤和神经鞘肿瘤中的RECQL4改变：表达模式及治疗意义
Sarra Belakhoua,Gianluca Lopez,Swati Dubey et al.
Sarra Belakhoua et al.
RECQL4 plays an important role in maintaining the integrity of the genome and regulating DNA replication. However, the role of RECQL4 in CNS tumors remains unknown. Sequencing data were reviewed and immunohistochemistry was performed on a v...
Christie G Turin,B K Kleinschmidt-DeMasters
Christie G Turin
Primary (idiopathic) hypophysitis is traditionally classified into lymphocytic, granulomatous, necrotizing, or IgG4-related disease types. Secondary hypophysitis occurs in patients with systemic conditions, which if known, often obviate the...
Clinical, morphological, and molecular characterization of patients with X-linked myopathy with excessive autophagy (XMEA) [0.03%]
临床、形态和分子特征分析过多自噬的x连锁肌病(XMEA)患者的特征
Angèle N Merlet,Emmanuelle Lacène,Isabelle Nelson et al.
Angèle N Merlet et al.
X-linked myopathy with excessive autophagy (XMEA) is a slowly progressive disease affecting male patients, caused by hemizygous mutations in the VMA21 gene. We studied nine patients from six unrelated French families clinically suspected of...
Analysis of anatomical location, mitoses, and Ki-67 in 2608 meningiomas [0.03%]
2608例脑膜瘤的解剖部位、有丝分裂及Ki-67分析
Anders Broechner,Andrea Daniela Maier,Christian Mirian et al.
Anders Broechner et al.
Ki-67 proliferation index (PI) and mitoses are frequent histopathological proliferation markers in meningioma diagnostics. They are used extensively in grading, with mitotic count constituting the major grading criterion in meningiomas but ...
Systemic microbial antigen administration ameliorates experimental autoimmune encephalomyelitis via MHC-II downregulation in the CNS and secondary lymphoid organs [0.03%]
系统性微生物抗原给药通过下调CNS和次级淋巴器官中的MHC-II改善自身免疫性脑脊髓炎
Marina Boziki,Paschalis Theotokis,Evangelia Kesidou et al.
Marina Boziki et al.
Microbial stimuli modulate CNS neuroinflammation but the exact molecular mechanisms are largely unknown. In this study, we aimed to delineate the effect of systemic pre-disease microbial antigen administration of 2 different microbial strai...
Myoglobin in cerebral aneurysm walls: Potential origin from smooth muscle-derived myofibroblasts and role in collagen retention [0.03%]
脑动脉瘤壁中的肌红蛋白：可能来源于平滑肌来源的肌成纤维细胞及其在胶原保留中的作用
Hidehito Kimura,Tatsuya Mori,Kosuke Hayashi et al.
Hidehito Kimura et al.
The mechanisms underlying cerebral aneurysm wall fragility remain unclear. Proteomic analysis has revealed predominant expression of myoglobin in thickened aneurysm wall regions. Given its nitric oxide-scavenging function, myoglobin may enh...