CD4+ T-lymphocytes in human saccular intracranial aneurysm walls are associated with aneurysm rupture [0.03%]
颅内动脉瘤壁中的CD4+T淋巴细胞与动脉瘤破裂有关
Nora Firtser,Eliisa Netti,Eliisa Kekäläinen et al.
Nora Firtser et al.
Chronic inflammation in saccular intracranial aneurysm (sIA) walls is associated with wall rupture. Previous studies have shown an association between macrophages and CD3+ T-lymphocytes with sIA wall degeneration and rupture but the roles o...
Compound muscle action potential as an early functional in vivo measure of Sarm1 inhibition after sciatic nerve transection [0.03%]
坐骨神经横断后SARM1抑制的早期功能学体内检测指标-复合肌肉动作电位检测法
Seong Kwon Hur,Rebecca R Leahey,Mitchell Geringer et al.
Seong Kwon Hur et al.
The NADase sterile alpha and TIR motif containing 1 (Sarm1) protein drives axon degeneration after injury. Loss or inhibition of Sarm1 structurally protects axons after sciatic nerve transection (SNT) in vivo but whether Sarm1 also drives f...
PAS+/PASD- intracytoplasmic glycogen is not specific for clear cell meningioma [0.03%]
PAS+/PASD-胞质糖原阳性并非透明细胞脑膜瘤特有现象
Merryl Terry,Gerald Reis,Melike Pekmezci et al.
Merryl Terry et al.
Photobiomodulation therapy: Location-dependent effects on memory and recovery in male adult rats with spinal cord injury [0.03%]
光生物调制治疗：脊髓损伤雄性成年大鼠记忆和恢复的部位依赖性效应
Majid Kazemi,Ali Motamed Nezhad,Razieh Hajisoltan et al.
Majid Kazemi et al.
Spinal cord injuries (SCIs) can cause significant physical and emotional challenges for individuals as a result of inflammation and cell death. This study investigates the effectiveness of photobiomodulation therapy (PBMT) in reducing infla...
Merlin immunoreactivity fails to predict neurofibromatosis type 2 mutations in human meningiomas [0.03%]
梅林免疫反应无法预测人类脑膜瘤中的神经纤维瘤病2型突变
Sofie Eline Tollefsen,Rahmina Meta,Ole Solheim et al.
Sofie Eline Tollefsen et al.
Deletion in 22q and mutations in the neurofibromatosis type 2 (NF2) gene are frequent in sporadic meningiomas. The tumor suppressor protein merlin is encoded by NF2, and mutations may promote tumor development. NF2 status is increasingly im...
A comparison of CDKN2A status in gliomas using different techniques: The loss of p16 as a surrogate marker [0.03%]
不同技术检测胶质瘤CDKN2A状态的比较：p16丢失作为替代标记物
Arnault Tauziède-Espariat,Audrey Rousseau,Laetitia Basset et al.
Arnault Tauziède-Espariat et al.
The presence of a CDKN2A homozygous deletion (HD) plays an important role in the diagnostic approach for neuropathologists and the clinical prognostic stratification of several CNS tumors. CDKN2A is located on chromosome 9p21 next to CDKN2B...
Shift of DNA methylation class may occur on recurrence of pleomorphic xanthoastrocytoma [0.03%]
多形性黄色星形细胞瘤复发时甲基化类型可能发生改变
Gonzalo Hernandez Gamero,Evelina Miele,Andrea Mafficini et al.
Gonzalo Hernandez Gamero et al.
Long non-coding RNAs plasmacytoma variant translocation 1 regulates bone marrow mesenchymal stem cell transplantation to promote the repair of spinal cord injury [0.03%]
长非编码RNA PLVAP1调控骨髓间充质干细胞移植促进脊髓损伤修复
Lei Gao,Peng Li,Ruize Yang et al.
Lei Gao et al.
This study investigated the therapeutic potential of long non-coding RNAs plasmacytoma variant translocation 1 (lncRNA PVT1) in regulating the function of bone marrow mesenchymal stem cells (BMSCs) following experimental spinal cord injury ...
Insights into holoprosencephaly using multimodal high-resolution imaging and 3D histology [0.03%]
基于多模态高分辨率影像和3D组织学的脑横裂发育不全研究取得新进展
Jaikishan Jayakumar,Jivitha Jyothi Ramesh,Rebecca D Folkerth et al.
Jaikishan Jayakumar et al.
Holoprosencephaly (HPE) is a well-described forebrain patterning disorder in mid-late gestation fetuses and infants. Here, we used a novel, whole-brain multimodal approach (ultrasonography, magnetic resonance imaging, and histology with 3-d...
Phospholipase C epsilon 1 aggravates β-amyloid-associated cognitive impairments and pyroptosis through activating the RAC1-STAT3 pathway in Alzheimer disease models [0.03%]
磷脂酶Cepsilon1通过激活RAC1-STAT3通路加剧阿尔茨海默病模型中的β淀粉样蛋白相关认知障碍和焦亡现象
Lijuan Pei,Wenjuan Hu,Li Wang et al.
Lijuan Pei et al.
Increased phospholipase C epsilon 1 (PLCE1) gene expression has been observed in patients with Alzheimer disease (AD), but its roles in AD remain unclear. This study aimed to explore the effects of PLCE1 expression in AD models. Rats were d...