Oculopharyngeal muscular dystrophy (OPMD) associated alanine expansion impairs the function of the nuclear polyadenosine RNA binding protein PABPN1 as revealed by proximity labeling and comparative proteomics [0.03%]
邻近标记和比较蛋白质组学揭示了与眼咽肌营养不良症（OPMD）相关的碱基扩展干扰核多聚腺苷RNA结合蛋白PABPN1的功能
Allison T Mezzell,Yu Zhang,Alexandra M Perez et al.
Allison T Mezzell et al.
Oculopharyngeal muscular dystrophy (OPMD) is a late-onset disease caused by modest alanine expansion at the amino terminus of the nuclear polyadenosine RNA binding protein PABPN1. PABPN1 is expressed ubiquitously and is involved in multiple...
Joint modeling of effect sizes for two correlated traits: Characterizing trait properties to enhance polygenic risk prediction [0.03%]
两种相关性状效应大小的联合建模：表征特征属性以增强多基因风险预测能力
Chi Zhang,Geyu Zhou,Tianqi Chen et al.
Chi Zhang et al.
Recent years have witnessed a surge in the development of innovative polygenic score (PGS) methods, driving their extensive application in disease prevention, monitoring, and treatment. However, the accuracy of genetic risk prediction remai...
Shared latent genetic liability across fibromyalgia and psychiatric traits: Novel insights from genomic structural equation modeling [0.03%]
纤维肌痛和精神病特征之间的共享潜在遗传易感性：基因组结构方程模型的全新见解
Liling Lin,Yankai Li,Fengtao Ji et al.
Liling Lin et al.
Background: Fibromyalgia, insomnia, depression, and anxiety share common clinical comorbidities, but their underlying genetic architecture and mechanism remain unclear. ...
An ArfGAP-dependent signaling modulates synaptic plasticity via IP3-regulated calcium release from the endoplasmic reticulum [0.03%]
一个ArfGAP依赖性信号通过IP3调节的内质网钙释放调控突触可塑性
Bhagaban Mallik,Shikha Kushwaha,Anjali Bisht et al.
Bhagaban Mallik et al.
Calcium release from intracellular stores influences synaptic response timing and magnitude. Despite the critical role of inositol trisphosphate (IP3)- and ryanodine receptor (RyR)-dependent calcium release in regulating synaptic strength, ...
Transcription factor ZEB2 is essential for ureteral smooth muscle cell differentiation [0.03%]
转录因子ZEB2对输尿管平滑肌细胞分化是必不可少的
Sudhir Kumar,Xueping Fan,Harshita Pattam et al.
Sudhir Kumar et al.
Mowat-Wilson Syndrome (MWS) is an autosomal dominant genetic disorder caused by heterozygous mutations or deletions in the Zinc finger E-box-binding homeobox 2 (ZEB2) gene. Congenital anomalies of the kidney and urinary tract (CAKUT), inclu...
A C. elegans model of copper deficiency: Dietary interventions rescue CTR1/CHCA-1 copper transporter mutant phenotype [0.03%]
铜缺乏症的秀丽隐杆线虫模型：饮食干预可缓解ctr1/chca-1铜转运蛋白突变体表型
Yang Fu,Xu Bai,Lei Chun et al.
Yang Fu et al.
Copper is an essential micronutrient for all living organisms. Mutations in the copper-importing transporter CTR1/CHCA-1 are associated with a severe copper deficiency disorder in humans, for which no effective cures are currently available...
Chromatin state architecture governs transcription factor accessibility across plant genomes [0.03%]
染色质状态构成调控植物基因组中的转录因子结合位点分布
Vikas Shukla,Elin Axelsson,Tetsuya Hisanaga et al.
Vikas Shukla et al.
The complexity of varied modifications of chromatin composition is integrated in archetypal combinations called chromatin states that predict the local potential for transcription. The degree of conservation of chromatin states has not been...
Molecular evolution of CO2-sensing ab1C neurons underlies divergent sensory responses in the Drosophila suzukii species group [0.03%]
japanese樱甲科果蝇二氧化碳感知神经元的分子进化及其种组中的感觉反应差异
Alice Gadau,Sasha Mills,Xin Yu Zhu Jiang et al.
Alice Gadau et al.
Organisms evolve behavioral and morphological traits to adapt to their ecological niches, yet the genetic basis of adaptation remains largely unknown. Drosophila suzukii has evolved a distinctive oviposition preference for ripe fruit, unlik...
20-hydroxyecdysone promotes brain development via upregulating MMP2 expression during metamorphosis in Helicoverpa armigera [0.03%]
20-羟基蜕皮酮通过在棉铃虫变态期上调MMP2表达促进脑发育
Can Tian,Pei-Yao Feng,Lin Wang et al.
Can Tian et al.
Matrix metalloproteinases (MMPs) play crucial roles in both physiological and pathological conditions by degrading the extracellular matrix; however, the roles and regulatory mechanisms of MMPs in brain development remain insufficiently und...
Correction: The C-terminal of CASY-1/Calsyntenin regulates GABAergic synaptic transmission at the Caenorhabditis elegans neuromuscular junction [0.03%]
纠正：CASY-1/Calsytenin的C端调控Caenorhabditis elegans神经肌肉接头中的GABA能突触传递
Shruti Thapliyal,Amruta Vasudevan,Yongming Dong et al.
Shruti Thapliyal et al.
[This corrects the article DOI: 10.1371/journal.pgen.1007263.]. Copyright: © 2026 Thapliyal et al. This is an open access article distributed under the ...
Published Erratum
PLoS genetics. 2026 Jan 20;22(1):e1012023. DOI:10.1371/journal.pgen.1012023 2026