Citrobacter rodentium infection activates colonic lamina propria group 2 innate lymphoid cells [0.03%]
柠檬酸杆菌感染激活结肠固有层2型先天淋巴细胞
Rita Berkachy,Vishwas Mishra,Priyanka Biswas et al.
Rita Berkachy et al.
Group 3 innate lymphoid cells (ILC3s) play a major role in protecting against infection with the enteric mouse pathogen Citrobacter rodentium (CR) used to model infections with enteropathogenic and enterohaemorrhagic Escherichia coli. ILC3s...
Disruption of riboflavin biosynthesis in mycobacteria establishes riboflavin pathway intermediates as key precursors of MAIT cell agonists [0.03%]
破坏分枝杆菌的核黄素生物合成确立了核黄素途径中间体作为MAIT细胞激动剂的关键前体
Melissa D Chengalroyen,Nurudeen Oketade,Aneta Worley et al.
Melissa D Chengalroyen et al.
Mucosal-associated invariant T (MAIT) cells exhibit an intrinsic ability to recognize and respond to microbial infections. The semi-invariant antigen recognition receptor of MAIT cells specifically detects the non-polymorphic antigen-presen...
Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease [0.03%]
七株多样性恙虫病东方体菌株的相对致病性分析，揭示了导致疾病的多种复杂的致病因子之间的相互作用
Panjaporn Chaichana,Naphat Satapoomin,Chitrasak Kullapanich et al.
Panjaporn Chaichana et al.
Orientia tsutsugamushi is an obligate intracellular bacterium found in Leptotrombidium mites that causes the human disease scrub typhus. A distinguishing feature of O. tsutsugamushi is its extensive strain diversity, yet differences in viru...
Resolving the APN controversy in PEDV infection: Comparative kinetic characterization through single-virus tracking [0.03%]
解析PEDV感染过程中的APN争议：通过单病毒追踪进行比较动力学表征
Da An,Yan Li,Yi Pei et al.
Da An et al.
Aminopeptidase N (APN) plays multiple roles in various physiological processes, with its function as a viral receptor in several coronaviruses being one of the most prominent. However, the role of porcine APN (pAPN) in porcine epidemic diar...
Arabidopsis CNL receptor SUT1 confers immunity in hydathodes against the vascular pathogen Xanthomonas campestris pv. campestris [0.03%]
拟南芥CNL受体SUT1介导水孔中的黑腐杆病Xcc免疫反应
Nanne W Taks,Marieke van Hulten,Jeroen A van Splunter-Berg et al.
Nanne W Taks et al.
Bacterial plant pathogens exploit natural openings, such as pores or wounds, to enter the plant interior and cause disease. Plants guard these openings through defense mechanisms. However, bacteria from the genus Xanthomonas have specialize...
Complex interactions in the life cycle of a simple parasite shape the evolution of virulence [0.03%]
生命周期中的复杂相互作用塑造了简单的寄生虫的致病性进化
Luís M Silva,Jacob C Koella
Luís M Silva
Evolutionary expectations about the virulence of parasites (i.e., the parasite-induced mortality rate of the host) often focus solely on the within-host transmission stage, overlooking the time spent between hosts and variations in transmis...
Viral hijacking of host DDX60 promotes Crimean-Congo haemorrhagic fever virus replication via G-quadruplex unwinding [0.03%]
宿主DDX60被病毒劫持通过G-四链体解旋促进克里米亚-刚果出血热病毒的复制
Yutong Sui,Qi Xu,Mingsheng Liu et al.
Yutong Sui et al.
Crimean-Congo haemorrhagic fever virus (CCHFV) is the most prevalent tick-borne zoonotic bunyavirus, causing severe hemorrhagic fever and fatality in humans. Currently, the absence of approved vaccines or therapeutics for CCHFV infection ne...
Strain-specific galactose utilization by commensal E. coli mitigates Salmonella establishment in the gut [0.03%]
肠道定植的Escherichia coli通过应激特异性半乳糖利用来抑制沙门氏菌定殖
Christopher Schubert,Jana Näf,Lisa Petukhov et al.
Christopher Schubert et al.
Salmonella enterica serovar Typhimurium (S. Tm) is a major cause of gastrointestinal diseases worldwide. To date, options for prevention or curative therapy remain limited. The gut microbiota plays a protective role against enteric diseases...
Natural self-attenuation of pathogenic viruses by deleting the silencing suppressor coding sequence for long-term plant-virus coexistence [0.03%]
通过删除沉默抑制子编码序列使病害病毒自然消减以实现植物与病毒的长期共存
Li Qin,Xiaoqing Wang,Zhaoji Dai et al.
Li Qin et al.
Potyviridae is the largest family of plant-infecting RNA viruses. All members of the family (potyvirids) have single-stranded positive-sense RNA genomes, with polyprotein processing as the expression strategy. The 5'-proximal regions of all...
Discovery of functional factorless internal ribosome entry site-like structures through virome mining [0.03%]
通过病毒组学挖掘发现功能性的无因子内部核糖体进入位点样结构
Subash Chapagain,Nicolas Salcedo-Porras,Amir Abdolahzadeh et al.
Subash Chapagain et al.
All viruses must co-opt the host translational machinery for viral protein synthesis. The dicistrovirus intergenic region internal ribosome entry site (IGR-IRES) utilizes the most streamlined translation mechanism by adopting a triple pseud...