A major role of class III HD-ZIPs in promoting sugar beet cyst nematode parasitism in Arabidopsis [0.03%]
糖 beet根线虫寄生拟南芥时class III HD-ZIP家族基因发挥了重要作用
Xunliang Liu,Melissa G Mitchum
Xunliang Liu
Cyst nematodes use a stylet to secrete CLE-like peptide effector mimics into selected root cells of their host plants to hijack endogenous plant CLE signaling pathways for feeding site (syncytium) formation. Here, we identified ATHB8, encod...
Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia [0.03%]
抑制中性粒细胞衣康酸的产生可减轻肺炎支原体肺炎症状
Cui Wang,Jun Wen,Zijun Yan et al.
Cui Wang et al.
Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in which neutrophils play a critical role. Immune-responsive gene 1 (IRG1), responsible for itaconate production, has emerged as an important regulator of inflammation ...
CD4+ but not CD8+ T cells are required for protection against severe guinea pig cytomegalovirus infections [0.03%]
CD4+,但不是CD8+T细胞,能够预防小种系非洲绿猴巨细胞病毒感染致严重疾病
Tyler B Rollman,Zachary W Berkebile,Dustin M Hicks et al.
Tyler B Rollman et al.
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus and the leading cause of infectious disease related birth defects worldwide. How the immune response modulates the risk of intrauterine transmission of HCMV after maternal infection r...
Tissue specific innate immune responses impact viral infection in Drosophila [0.03%]
组织特异性先天免疫反应影响果蝇的病毒感染
Elisha Segrist,Steven Miller,Beth Gold et al.
Elisha Segrist et al.
All organisms sense and respond to pathogenic challenge. Tissue-specific responses are required to combat pathogens infecting distinct cell types. Cyclic dinucleotides (CDNs) are produced endogenously downstream of pathogen recognition or b...
Copper acquisition is essential for plant colonization and virulence in a root-infecting vascular wilt fungus [0.03%]
铜的获取对根系侵染型枯萎病菌的植物定殖和致病性是必不可少的
Rafael Palos-Fernández,María Victoria Aguilar-Pontes,Gema Puebla-Planas et al.
Rafael Palos-Fernández et al.
Plant pathogenic fungi provoke devastating agricultural losses and are difficult to control. How these organisms acquire micronutrients during growth in the host environment remains poorly understood. Here we show that efficient regulation ...
Adaptation of Candida albicans to specific host environments by gain-of-function mutations in transcription factors [0.03%]
白念珠菌通过转录因子的获得性功能突变适应宿主特定环境
Joachim Morschhäuser
Joachim Morschhäuser
The yeast Candida albicans is usually a harmless member of the normal microbiota in healthy persons but is also a major fungal pathogen that can colonize and infect almost every human tissue. A successful adaptation to environmental changes...
A novel esterase regulates Klebsiella pneumoniae hypermucoviscosity and virulence [0.03%]
一种新型酯酶调节肺炎克雷伯氏菌的高粘性和致病性
Lijun Wang,Zhe Wang,Hua Zhang et al.
Lijun Wang et al.
Klebsiella pneumoniae, an emerging multidrug-resistant pathogen, exhibits hypermucoviscosity (HMV) as a critical virulence trait mediated by its capsular polysaccharide (CPS). Recent discoveries have determined acetylation as a significant ...
From acute to persistent infection: revealing phylogenomic variations in Salmonella Agona [0.03%]
从急性感染到持续性感染——解密沙门氏菌Agona的基因组变异
Emma V Waters,Winnie W Y Lee,Amina Ismail Ahmed et al.
Emma V Waters et al.
Salmonella enterica serovar Agona (S. Agona) has been increasingly recognised as a prominent cause of gastroenteritis. This serovar is a strong biofilm former that can undergo genome rearrangement and enter a viable but non-culturable state...
Htay Mon Aye,Feng-Jun Li,Cynthia Y He
Htay Mon Aye
Stress granules (SGs) are stress-induced RNA condensates consisting of stalled initiation complexes resulting from translational inhibition. The biochemical composition and function of SGs are highly diverse, and this diversity has been att...
Chad Gebo,Céline S C Hardy,Benjamin D McElvany et al.
Chad Gebo et al.
Dengue virus (DENV) is the causative agent of dengue, a mosquito-borne disease that represents a significant and growing public health burden around the world. A unique pathophysiological feature of dengue is immune-mediated enhancement, wh...