Malnutrition disrupts adaptive immunity during visceral leishmaniasis by enhancing IL-10 production [0.03%]
营养不良通过增强IL-10的产生干扰内脏利什曼病的适应性免疫反应
Laís Amorim Sacramento,Claudia Gonzalez-Lombana,Phillip Scott
Laís Amorim Sacramento
Protein-energy malnutrition (PEM) is a risk factor for developing visceral leishmaniasis (VL). While nutrient deficiency can impair immunity, its mechanistic impact on protective adaptive immune responses following Leishmania infection rema...
TRIM32 inhibits Venezuelan equine encephalitis virus infection by targeting a late step in viral entry [0.03%]
TRIM32通过作用于病毒进入途径的晚期阶段来抑制委内瑞拉马脑炎病毒感染
Yifan Xie,Jie Cao,Shuyi Gan et al.
Yifan Xie et al.
Alphaviruses are mosquito borne RNA viruses that are a reemerging public health threat. Alphaviruses have a broad host range, and can cause diverse disease outcomes like arthritis, and encephalitis. The host ubiquitin proteasome system (UPS...
Critical role of Babesia bovis spherical body protein 3 in ridge formation on infected red blood cells [0.03%]
恶性疟原虫受染红细胞突起和环状体形成的关键调节因子
Atefeh Fathi,Hassan Hakimi,Miako Sakaguchi et al.
Atefeh Fathi et al.
Babesia bovis, an apicomplexan intraerythrocytic protozoan parasite, causes serious economic loss to cattle industries around the world. Infection with this parasite leads to accumulation of infected red blood cells (iRBCs) in the brain mic...
Super broad and protective nanobodies against Sarbecoviruses including SARS-CoV-1 and the divergent SARS-CoV-2 subvariant KP.3.1.1 [0.03%]
针对包括SARS-CoV-1和分化出的SARS-CoV-2(KP.3.1.1谱系)等沙贝科病毒的超广谱保护型纳米抗体
Haodi Dong,Runhong Zhou,Jing Chen et al.
Haodi Dong et al.
The ongoing evolution and immune escape of SARS-CoV-2, alongside the potential threat of SARS-CoV-1 and other sarbecoviruses, underscore the urgent need for effective strategies against their infection and transmission. This study highlight...
Use of the Puccinia sorghi haustorial transcriptome to identify and characterize AvrRp1-D recognized by the maize Rp1-D resistance protein [0.03%]
利用Puccinia sorghi锈菌效应子文库筛选并鉴定玉米基因Rp1-D识别的AvrRp1-D蛋白及其功能分析
Saet-Byul Kim,Ki-Tae Kim,Solhee In et al.
Saet-Byul Kim et al.
The common rust disease of maize is caused by the obligate biotrophic fungus Puccinia sorghi. The maize Rp1-D allele imparts resistance against the P. sorghi IN2 isolate by initiating a defense response that includes a rapid localized progr...
Structural basis for human DPP4 receptor recognition by a pangolin MERS-like coronavirus [0.03%]
穿山甲冠状病毒MERS样受体结合域与人类二肽基肽酶4的结构基础
Mo Yang,Zehou Li,Jing Chen et al.
Mo Yang et al.
Middle East respiratory syndrome coronavirus (MERS-CoV) and the pangolin MERS-like coronavirus MjHKU4r-CoV-1 employ dipeptidyl peptidase 4 (DPP4) as an entry receptor. MjHKU4r-CoV-1 could infect transgenic mice expressing human DPP4. To und...
Retraction: p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication [0.03%]
撤稿：p53通过促进ZDHHC1介导的IFITM3棕榈酰化抑制日本脑炎病毒复制
PLOS Pathogens Editors
PLOS Pathogens Editors
Retraction of Publication
PLoS pathogens. 2024 Nov 8;20(11):e1012698. DOI:10.1371/journal.ppat.1012698 2024
Reduction of antisense transcription affects bovine leukemia virus replication and oncogenesis [0.03%]
反义转录降低影响牛白血病病毒的复制和致癌性
Thomas Joris,Thomas Jouant,Jean-Rock Jacques et al.
Thomas Joris et al.
In sheep infected with bovine leukemia virus (BLV), transcription of structural, enzymatic, and accessory genes is silenced. However, the BLV provirus transcribes a series of non-coding RNAs that remain undetected by the host immune respons...
Metarhizium fight club: Within-host competitive exclusion and resource partitioning [0.03%]
芽枝霉“Fight Club”：“内源竞争淘汰与资源分配分区现象”
Huiyu Sheng,Raymond J St Leger
Huiyu Sheng
Both Metarhizium robertsii ARSEF 2575 (Mr2575) and Metarhizium anisopliae ARSEF 549 (Ma549) infect a range of insects whilst also interacting with plants; however, little is known about the traits that affect the competitive ability of diff...
A viral p3a protein targets and inhibits TaDOF transcription factors to promote the expression of susceptibility genes and facilitate viral infection [0.03%]
病毒p3a蛋白靶向并抑制TaDOF转录因子以促进感病基因的表达和帮助病毒感染
Shuyuan Tian,Qingting Song,Yipeng Cheng et al.
Shuyuan Tian et al.
The interactions among viruses and host plants are complex and fascinating because these organisms interact with and adapt to each other continuously. Many plant transcription factors play important roles in plant growth and development and...