Integrative glycomic analysis reveals the crucial role of protein glycosylation in fungal pathogenesis [0.03%]
整合糖组分析揭示了蛋白质糖基化在真菌致病性中的关键作用
Heeji Moon,Eun Jung Thak,Yejin Choi et al.
Heeji Moon et al.
Protein glycosylation, a co- and post-translational modification that enhances the functional diversity of the proteome, contributes to various molecular and cellular functions by transferring different polysaccharides onto proteins. During...
Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite Plasmodium berghei [0.03%]
辅丝裂原活化蛋白激酶磷酸酶-1同源物6在雷诺氏综合征和肢端紫绀症中功能缺失
Yonghui Feng,Wenyan Gao,Chengqi Wang et al.
Yonghui Feng et al.
Protein phosphorylation plays a critical role during the development of malaria parasites. Here, we performed a functional analysis of the Plasmodium berghei Ser/Thr protein phosphatase 6 (PbPP6), which is associated with the plasma membran...
The neonatal Fc receptor (FcRn): Guardian or Trojan Horse in viral infection? [0.03%]
新生儿Fc受体（FcRn）：病毒感染中的守护者还是特洛伊木马？
Lei Na,Yang Zheng,Jian-Bo Yang et al.
Lei Na et al.
The neonatal Fc receptor (FcRn), well-known for mediating the transfer of maternal immunoglobulin G (IgG) to neonates, plays a critical role in neonatal antimicrobial defenses. Furthermore, FcRn regulates IgG and albumin homeostasis via pH-...
The spread of highly pathogenic avian influenza virus is a social network problem [0.03%]
高致病性禽流感病毒的传播是一个社会网络问题
Jamie Dunning,Josh A Firth,Alastair I Ward
Jamie Dunning
Despite identification of Highly Pathogenic Avian Influenza viruses nearly 75 years ago, the transmission pathways among wild animals remain incompletely described. We propose the use of social networks, to complement phylodynamic modeling,...
Identification of picornavirus proteins that inhibit de novo nucleotide synthesis during infection [0.03%]
鉴定出抑制新病毒感染时从头合成核苷酸的的小RNA病毒蛋白
Lonneke V Nouwen,Esther A Zaal,Inge Buitendijk et al.
Lonneke V Nouwen et al.
Viruses, including picornaviruses, modulate cellular metabolism to generate sufficient building blocks for virus replication and dissemination. Previously, we showed that two picornaviruses, coxsackievirus B3 (CVB3) and EMCV, remodel nucleo...
Anticoagulant therapy and altered tissue factor expression protect against experimental placental and cerebral malaria [0.03%]
抗凝疗法和组织因子表达改变可预防实验性胎盘疟疾和脑疟疾
Alicer K Andrew,Tara C Bracken,Nicole M Nazario-Maldonado et al.
Alicer K Andrew et al.
Severe malaria remains a major public health concern in regions of moderate to high Plasmodium falciparum transmission. Women and young children are especially vulnerable to two clinical manifestations of severe P. falciparum malaria, known...
TNF signaling mediates cellular immune function and promotes malaria parasite killing in the mosquito Anopheles gambiae [0.03%]
肿瘤坏死因子信号介导蚊虫的细胞免疫功能并促进疟原虫的杀灭——以冈比亚按蚊为例
George-Rafael Samantsidis,Hyeogsun Kwon,Megan Wendland et al.
George-Rafael Samantsidis et al.
Tumor Necrosis Factor-α (TNF-α) is a proinflammatory cytokine and a master regulator of immune cell function in vertebrates. While previous studies have implicated TNF signaling in invertebrate immunity, the roles of TNF in mosquito innat...
Hexosamine biosynthesis disruption impairs GPI production and arrests Plasmodium falciparum growth at schizont stages [0.03%]
己糖胺生物合成干扰破坏糖基磷脂酰肌醇的产生并阻断恶性疟原虫裂殖体阶段的生长发育
María Pía Alberione,Yunuen Avalos-Padilla,Gabriel W Rangel et al.
María Pía Alberione et al.
UDP-N-acetylglucosamine (UDP-GlcNAc) is a crucial sugar nucleotide for glycan synthesis in eukaryotes. In the malaria parasite Plasmodium falciparum, UDP-GlcNAc is synthesized via the hexosamine biosynthetic pathway (HBP) and is essential f...
The non-structural protein of SFTSV activates NLRP1 and CARD8 inflammasome through disrupting the DPP9-mediated ternary complex [0.03%]
非结构性SFTSV蛋白通过破坏DPP9介导的三元复合体激活NLRP1和CARD8炎症小体
Pan-Pan Liu,Shu-Peng Jiang,Bang Li et al.
Pan-Pan Liu et al.
Inflammasomes function as immune-signaling platforms that were assembled following detection of pathogens. NLRP1 and CARD8 are related inflammasomes that use their C-terminal (CT) fragments containing a caspase recruitment domain (CARD) and...
Advances in understanding multifunctionality of Barley stripe mosaic virus γb protein [0.03%]
大麦条纹花叶病毒γb蛋白多重功能性的研究进展
Zhihao Jiang,Meng Yang,Dawei Li
Zhihao Jiang
Plant viruses usually encode versatile but limited number of proteins to reshape the cellular microenvironment, suppress or co-opt host pathways and proteins for their own benefit. Barley stripe mosaic virus (BSMV, Hordeivirus hordei) is a ...