Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target [0.03%]
天然产物介导的反应劫持机制验证了疟原虫天冬氨酰-tRNA合成酶是抗疟药物靶点
Nutpakal Ketprasit,Chia-Wei Tai,Vivek Kumar Sharma et al.
Nutpakal Ketprasit et al.
Malaria poses an enormous threat to human health. With ever-increasing resistance to currently deployed antimalarials, new targets and starting point compounds with novel mechanisms of action need to be identified. Here, we explore the anti...
Secreted ISG15 induced by Chlamydia trachomatis infection exerts immunomodulatory effects on IFN-γ defense and inflammation [0.03%]
沙眼衣原体感染诱导的分泌型ISG15对干扰素γ介导的免疫防御及炎症的调控作用
Yongxia Guo,Sigrun V Stulz,David Komla Kessie et al.
Yongxia Guo et al.
Interferon-γ (IFN-γ) is an immunoregulatory cytokine essential for cellular immunity against intracellular pathogens, including Chlamydia. Interferon-stimulated gene (ISG) 15, a member of the ubiquitin family, contributes to host resistan...
Baculovirus enhances arginine uptake and induces mitochondrial autophagy to promote viral proliferation [0.03%]
杆状病毒增强精氨酸吸收和诱导线粒体自噬以促进病毒增殖
Shigang Fei,Junming Xia,Yigui Huang et al.
Shigang Fei et al.
As obligatory intracellular parasites, viruses must rely on metabolic reprogramming of host cells to meet their replication needs. Baculovirus is an important biopesticide and a vector for the preparation of biological products. In addition...
Essential role for PfHSP40 in asexual replication and thermotolerance of malaria parasites [0.03%]
恶性疟原虫PfHSP40蛋白在疟疾寄生虫无性繁殖和耐热中的作用机制研究
Brianne Roper,Deepika Kannan,Emily S Mathews et al.
Brianne Roper et al.
Plasmodium falciparum, the parasite responsible for nearly all cases of severe malaria, must survive challenging environments to persist in its human host. Symptomatic malaria is characterized by periodic fevers corresponding to the 48-hour...
In vitro HIV DNA integration in STAT3 drives T cell persistence-A model of HIV-associated T cell lymphoma [0.03%]
体外HIVDNA整合到STAT3中可驱动T细胞持续存在-一种HIV相关T细胞淋巴瘤模型
Michael Rist,Machika Kaku,John M Coffin
Michael Rist
Oncogenic retroviruses are known for their pathogenesis via insertional mutagenesis, in which the presence of a provirus and its transcriptional control elements alter the expression of a nearby or surrounding host gene. There are reports o...
Biochemical and structural characterization of the human gut microbiome metallopeptidase IgAse provides insight into its unique specificity for the Fab' region of IgA1 and IgA2 [0.03%]
人肠道微生物金属肽酶IgAse的生化和结构表征为其与IgA1和IgA2的Fab’区的独特特异性的独特特性提供了见解
Juan Sebastián Ramírez-Larrota,Pauline Juyoux,Pablo Guerra et al.
Juan Sebastián Ramírez-Larrota et al.
Human immunoglobulin A (IgA), comprising the isotypes IgA1 and IgA2, protects ~400 m2 of mucosal surfaces against microbial infections but can also lead to aberrant IgA deposits that cause disease. Certain bacteria have evolved peptidases t...
RNF213 regulates blood‒brain barrier integrity by targeting TRAF3 for type I interferon activation during A. baumannii infection [0.03%]
RNF213通过靶向TRAF3激活I型干扰素在baumannii感染期间调节血脑屏障完整性
Yanfeng Li,Qingqing Xie,Luyu Yang et al.
Yanfeng Li et al.
RNF213 is the first identified susceptibility gene for moyamoya disease, and the encoded protein was recently recognized as a key antimicrobial protein. However, the function of RNF213 in host defense against brain infection remains unclear...
Bacterial and host enzymes modulate the pro-inflammatory response elicited by the peptidoglycan of Lyme disease agent Borrelia burgdorferi [0.03%]
细菌和宿主酶可调节由莱姆病病原体伯氏疏螺旋体的肽聚糖引起的促炎反应
Joshua W McCausland,Zachary A Kloos,Irnov Irnov et al.
Joshua W McCausland et al.
The spirochete Borrelia burgdorferi causes Lyme disease. In some patients, an excessive, dysregulated proinflammatory immune response can develop in joints leading to persistent arthritis even after antibiotic therapy. In such patients, per...
Proximity labelling of internalizing influenza A viruses reveals a role for neogenin in virus uptake [0.03%]
邻近标记鉴定出内化的流感病毒A宿主因子并揭示了新基因在病毒进入中的作用
Milagros Sempere Borau,Victor G Gisbert,Josephine von Kempis et al.
Milagros Sempere Borau et al.
Influenza A virus (IAV) is a respiratory pathogen of global concern. Entry of most IAVs is mediated by binding of viral hemagglutinin to cellular sialic acid, facilitating virus attachment. A subsequent interaction with a surface receptor(s...
Yersinia pseudotuberculosis growth arrest during type-III secretion system expression is associated with altered ribosomal protein expression and decreased gentamicin susceptibility [0.03%]
耶尔森菌假结核亚种在三型分泌系统表达期间生长停止与核糖体蛋白表达改变及对庆大霉素敏感性降低有关
Justin Greene,Katherine L Cotten,Rhett A Snyder et al.
Justin Greene et al.
It has been long appreciated that expression of the Yersinia type-III secretion system (T3SS) in culture is associated with growth arrest. Here we sought to understand whether T3SS expression is sufficient to trigger loss of exponential pha...