NS1-mediated DNMT1 degradation regulates human bocavirus 1 replication and RNA processing [0.03%]
NS1介导的DNMT1降解调节人博卡病毒1复制和RNA加工
Shuangkang Qin,Honghe Chen,Chuchu Tian et al.
Shuangkang Qin et al.
Methylation of the DNA genome plays an important role in viral gene inactivation. However, the role of DNA methylation in human bocavirus (HBoV) remains unclear. In this study, the HBoV1 genomic DNA was found extensively methylated at the C...
Dynamin independent endocytosis is an alternative cell entry mechanism for multiple animal viruses [0.03%]
dynamin独立的内吞作用是多种动物病毒的替代细胞入侵机制
Ravi Ojha,Anmin Jiang,Elina Mäntylä et al.
Ravi Ojha et al.
Mammalian receptor-mediated endocytosis (RME) often involves at least one of three isoforms of the large GTPase dynamin (Dyn). Dyn pinches-off vesicles at the plasma membrane and mediates uptake of many viruses, although some viruses direct...
Tackling immunosuppression by Neisseria gonorrhoeae to facilitate vaccine design [0.03%]
淋球菌免疫抑制作用及其疫苗设计中的应对措施
Rebekah A Jones,Fidel Ramirez-Bencomo,Gail Whiting et al.
Rebekah A Jones et al.
Gonorrhoea, caused by Neisseria gonorrhoeae, is a common sexually transmitted infection. Increasing multi-drug resistance and the impact of asymptomatic infections on sexual and reproductive health underline the need for an effective gonoco...
Single-cell transcriptomics unveils skin cell specific antifungal immune responses and IL-1Ra- IL-1R immune evasion strategies of emerging fungal pathogen Candida auris [0.03%]
单细胞转录组揭示了皮肤细胞特异性抗真菌免疫反应以及新兴病原真菌耳念珠菌的IL-1Ra-IL-1R免疫逃避策略
Abishek Balakumar,Diprasom Das,Abhishek Datta et al.
Abishek Balakumar et al.
Candida auris is an emerging multidrug-resistant fungal pathogen that preferentially colonizes and persists in skin tissue, yet the host immune factors that regulate the skin colonization of C. auris in vivo are unknown. In this study, we e...
ACE2-independent sarbecovirus cell entry can be supported by TMPRSS2-related enzymes and can reduce sensitivity to antibody-mediated neutralization [0.03%]
TMPRSS2相关酶可以支持不含ACE2的sarbecovirus细胞进入并降低抗体介导中和的敏感性
Lu Zhang,Hsiu-Hsin Cheng,Nadine Krüger et al.
Lu Zhang et al.
The COVID-19 pandemic, caused by SARS-CoV-2, demonstrated that zoonotic transmission of animal sarbecoviruses threatens human health but the determinants of transmission are incompletely understood. Here, we show that most spike (S) protein...
EhRacM differentially regulates macropinocytosis and motility in the enteric protozoan parasite Entamoeba histolytica [0.03%]
EHRACM区别调节肠道原生动物病原体溶组织内阿米巴的巨胞饮和运动性
Misato Shimoyama,Kumiko Nakada-Tsukui,Tomoyoshi Nozaki
Misato Shimoyama
Macropinocytosis is an evolutionarily conserved endocytic process that plays a vital role in internalizing extracellular fluids and particles in cells. This non-selective endocytic pathway is crucial for various physiological functions such...
Mycoplasma bovis 5'-nucleotidase is a virulence factor conferring mammary fitness in bovine mastitis [0.03%]
牛支原体5'-核苷酸酶是一种赋予乳腺竞争性的毒力因子
Aga E Gelgie,Peleg Schneider,Christine Citti et al.
Aga E Gelgie et al.
Nucleases and 5' nucleotidase (5'-NT) play essential roles in cell biology and are often associated with bacterial virulence. In Mycoplasma spp., which have limited metabolic capacities and rely on nutrient availability, these enzymes are o...
Anchorage of bacterial effector at plasma membrane via selective phosphatidic acid binding to modulate host cell signaling [0.03%]
细菌效应物通过选择性结合磷脂酸锚定到细胞膜以调节宿主信号转导
Meng Wang,Qixiao Guan,Chunyan Wang et al.
Meng Wang et al.
Binding phospholipid is a simple, yet flexible, strategy for anchorage of bacterial effectors at cell membrane to manipulate host signaling responses. Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-biphosphate are the only tw...
A model of lymphocryptovirus-associated post-transplant lymphoproliferative disorder in immunosuppressed Mauritian cynomolgus macaques [0.03%]
一种淋巴细胞性脉络丛脑膜炎病毒相关的移植物抗宿主病小鼠模型免疫抑制毛里求斯猕猴模拟人移植后淋巴细胞增生性疾病模型
Helen L Wu,Whitney C Weber,Courtney M Waytashek et al.
Helen L Wu et al.
Immunocompromised individuals are at risk for developing lymphocryptovirus-associated lymphoproliferative diseases, such as Epstein Barr virus (EBV)-associated B cell lymphomas and post-transplant lymphoproliferative disorder (PTLD). We pre...
The Plasmodium transmission-blocking symbiont, Microsporidia MB, is vertically transmitted through Anopheles arabiensis germline stem cells [0.03%]
疟蚊小抱子虫(MB)通过按蚊的生殖系干细胞垂直传播阻断疟原虫传播
Thomas Ogao Onchuru,Edward Edmond Makhulu,Purity Cassandra Ronnie et al.
Thomas Ogao Onchuru et al.
Microsporidia MB is a promising candidate for developing a symbiont-based strategy for malaria control because it disrupts the capacity of An. arabiensis to transmit the Plasmodium parasite. The symbiont is predominantly localized in the re...