AGC family kinase of Entamoeba histolytica: Decoding the members biochemically [0.03%]
溶组织内阿米巴AGC家族激酶：生物化学解析成员属性
Azhar Ahmad,Vikas Kumar,Tushar Kushwaha et al.
Azhar Ahmad et al.
Entamoeba histolytica, a protozoan parasite, is the causative agent of amoebiasis, which is a significant global health concern. The virulence mechanisms underlying its pathogenicity are multifaceted and complex. However, endocytic processe...
The Cryptococcus neoformans STRIPAK complex controls genome stability, sexual development, and virulence [0.03%]
新型隐球菌STRIPAK复合体调控基因组稳定性、有性发育和致病力
Patricia P Peterson,Jin-Tae Choi,Ci Fu et al.
Patricia P Peterson et al.
The eukaryotic serine/threonine protein phosphatase PP2A is a heterotrimeric enzyme composed of a scaffold A subunit, a regulatory B subunit, and a catalytic C subunit. Of the four known B subunits, the B"' subunit (known as striatin) inter...
Antagonism of BST2/Tetherin, a new restriction factor of respiratory syncytial virus, requires the viral NS1 protein [0.03%]
新的呼吸道合胞病毒限制因子BST2/Tetherin的拮抗需要病毒NS1蛋白参与
Katherine Marougka,Delphine Judith,Tristan Jaouen et al.
Katherine Marougka et al.
Human respiratory syncytial virus (RSV) is an enveloped RNA virus and the leading viral agent responsible for severe pediatric respiratory infections worldwide. Identification of cellular factors able to restrict viral infection is one of t...
Polyamines mediate cellular energetics and lipid metabolism through mitochondrial respiration to facilitate virus replication [0.03%]
多胺通过线粒体呼吸作用调节细胞能量和脂质代谢以促进病毒复制
Yazmin E Cruz-Pulido,Natalie J LoMascolo,Delaina May et al.
Yazmin E Cruz-Pulido et al.
Polyamines are critical cellular components that regulate a variety of processes, including translation, cell cycling, and nucleic acid metabolism. The polyamines, putrescine, spermidine, and spermine, are found abundantly within cells and ...
The blast pathogen effector AVR-Pik binds and stabilizes rice heavy metal-associated (HMA) proteins to co-opt their function in immunity [0.03%]
稻瘟菌效应蛋白AVR-Pik结合并稳定水稻重金属相关(HMA)蛋白以劫持其功能从而影响免疫反应
Kaori Oikawa,Koki Fujisaki,Motoki Shimizu et al.
Kaori Oikawa et al.
Intracellular nucleotide-binding domain and leucine-rich repeat-containing (NLR) receptors play crucial roles in immunity across multiple domains of life. In plants, a subset of NLRs contain noncanonical integrated domains that are thought ...
Attenuated Getah virus confers protection against multiple arthritogenic alphaviruses [0.03%]
减毒Getah病毒对多种关节致病性甲病毒具有保护作用
Zhiwen Jiang,Andres Merits,Ying Qin et al.
Zhiwen Jiang et al.
Alphaviruses are important arthropod-transmitted pathogens of humans and livestock. Getah virus (GETV) is an arthritogenic alphavirus that causes disease in horses and piglets; it also poses a potential threat to humans. A live attenuated v...
Profiling serum immunodominance following SARS-CoV-2 primary and breakthrough infection reveals distinct variant-specific epitope usage and immune imprinting [0.03%]
对SARS-CoV-2初次感染和突破性感染后血清免疫优势谱分析揭示了不同的变种特异性表位使用情况及免疫印记现象
Jeffrey Seow,George C E Jefferson,Michael D Keegan et al.
Jeffrey Seow et al.
Over the course of the COVID-19 pandemic, variants have emerged with increased mutations and immune evasive capabilities. This has led to breakthrough infections (BTI) in vaccinated individuals, with a large proportion of the neutralizing a...
Mucosal immunization with the lung Lactobacillus-derived amphiphilic exopolysaccharide adjuvanted recombinant vaccine improved protection against P. aeruginosa infection [0.03%]
一种新型重组疫苗通过呼吸道黏膜免疫改善铜绿假单胞菌感染防护作用
Haochi Zhang,Shouxin Sheng,Chunhe Li et al.
Haochi Zhang et al.
Respiratory infections caused by Pseudomonas aeruginosa are a major health problem globally. Current treatment for P. aeruginosa infections relies solely on antibiotics, but the rise of antibiotic-resistant strains necessitates an urgent ne...
The T4bSS of Legionella features a two-step secretion pathway with an inner membrane intermediate for secretion of transmembrane effectors [0.03%]
Legionella的T4bSS通过中间内膜途径分泌跨膜效应物具有两步分泌机制特征
Silke Malmsheimer,Iwan Grin,Erwin Bohn et al.
Silke Malmsheimer et al.
To promote intracellular survival and infection, Legionella spp. translocate hundreds of effector proteins into eukaryotic host cells using a type IV b protein secretion system (T4bSS). T4bSS are well known to translocate soluble as well as...
Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses [0.03%]
蝙蝠SARS相关冠状病毒增强受体结合和细胞侵入的进化路径
Alexandra L Tse,Cory M Acreman,Inna Ricardo-Lax et al.
Alexandra L Tse et al.
Understanding the zoonotic risks posed by bat coronaviruses (CoVs) is critical for pandemic preparedness. Herein, we generated recombinant vesicular stomatitis viruses (rVSVs) bearing spikes from divergent bat CoVs to investigate their cell...