A highly potent human antibody neutralizing all serotypes of BK polyomavirus [0.03%]
一种能有效中和全部血清型BK多瘤病毒的人类单克隆抗体
Marcel Weber,Simone Schmitt,Barbara Eicher et al.
Marcel Weber et al.
BK polyomavirus infection poses a significant risk to kidney transplant recipients. Reactivation of dormant virus in the transplanted kidney, triggered by immunosuppression, can lead to BK polyomavirus-associated nephropathy in up to 10% of...
Functional characterization of DPP4 and FcRn as receptor and coreceptor for classical human astroviruses in Caco-2 cells [0.03%]
DPP4和FcRn作为经典人类轮状病毒受体和共受体在Caco-2细胞中的功能表征
Catalina Aguilera-Flores,María Del Pilar Valencia-Morales,Tomás López et al.
Catalina Aguilera-Flores et al.
Classical human astroviruses (HAstV) are a global cause of viral gastroenteritis, particularly in children and immunocompromised individuals. Despite their clinical significance, the biology of HAstV remains poorly understood. In particular...
Hantaan virus-derived peptides that stabilize HLA-E could abrogate inhibition of CD56dimNKG2A+ NK cells [0.03%]
汉坦病毒衍生多肽可通过稳定HLA-E分子消除CD56dimNKG2A+NK细胞的抑制作用
Manling Xue,Kang Tang,Yusi Zhang et al.
Manling Xue et al.
NK cells could participate in the pathogenesis process of virus infectious diseases through the inhibitory receptor CD94/NKG2A interacting with HLA-E/virus-derived peptide complex. However, the effects and mechanisms of NKG2A-HLA-E axis-med...
Sara Branco,Peter G Avis,Kerrie Barry et al.
Sara Branco et al.
Fungi are important and hyperdiverse organisms, yet chronically understudied. Most fungal clades have no reference genomes, impeding our understanding of their ecosystem functions and use as solutions in health and biotechnology. Also, oppo...
The conserved transcription factor PrlP modulates colonization and pathogenicity of Streptococcus suis in response to environmental stress [0.03%]
转录因子PrlP通过响应环境压力调节猪链球菌定植和致病性
Yuhua Wang,Ran Liu,Weihua Lv et al.
Yuhua Wang et al.
Opportunistic pathogens can cause infections when host defenses are compromised. Among them, Streptococcus suis (S. suis) colonizes the upper respiratory tract of pigs and causes severe diseases in both swine and humans. Although the pathog...
Profiling miRNA changes in Epstein-Barr virus lytic infection identifies a function for BZLF1 in upregulating miRNAs from the DLK1-DIO3 locus [0.03%]
EB病毒裂解感染的miRNA变化特征分析鉴定BZLF1对DLK1-DIO3位点上miRNA表达上调的作用
Ashley M Campbell,Victoria C Taylor,Beata Cohan et al.
Ashley M Campbell et al.
Cellular and viral miRNAs are thought to play important roles in regulating Epstein-Barr virus (EBV) latent and lytic infections, however, to date, most studies have focussed on latent infections in B-cells. To determine how cellular and vi...
A second-generation molecular clamp stabilised bivalent candidate vaccine for protection against diseases caused by respiratory syncytial virus and human metapneumovirus [0.03%]
一种二代分子钳稳定、兼具抗呼吸道合胞病毒和人副流感病毒的双价候选疫苗
Andrew Young,Sharada Kolekar,Carlos Alvarez Mendoza et al.
Andrew Young et al.
Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are two medically important causes of respiratory tract infections and diseases. After more than five decades of research and development, vaccines have recently been approv...
Membrane-wide screening identifies potential tissue-specific determinants of SARS-CoV-2 tropism [0.03%]
膜广泛筛选识别出潜在的组织特异性SARS-CoV-2嗜性决定因子
Ravi K Dinesh,Chengkun Wang,Yuanhao Qu et al.
Ravi K Dinesh et al.
While SARS-CoV-2 primarily infects the respiratory tract, clinical evidence indicates that cells from diverse cell types and organs are also susceptible to infection. Using the CRISPR activation (CRISPRa) approach, we systematically targete...
Spatio-genetically coordinated TPR domain-containing proteins modulate c-di-GMP signaling in Vibrio vulnificus [0.03%]
副溶血性弧菌中TPR结构域蛋白调控c-di-GMP信号通路的时空遗传机制研究
Shobnom Mustaree,Ram Podicheti,Doug Rusch et al.
Shobnom Mustaree et al.
Vibrio species, which include several pathogens, are autochthonous to estuarine and warm coastal marine environments, where biofilm formation bolsters their ecological persistence and transmission. Here, we identify a bicistronic operon, rc...
The African swine fever virus p22 inhibits the JAK-STAT signaling pathway by promoting the TAX1BP1-mediated degradation of the type I interferon receptor [0.03%]
非洲猪瘟病毒p22通过促进I型干扰素受体的TAX1BP1介导的降解来抑制JAK-STAT信号通路
Haojie Ren,Yanjin Wang,Lian-Feng Li et al.
Haojie Ren et al.
African swine fever virus (ASFV) is the causative agent of African swine fever (ASF), a devastating disease epidemic in Asia and Europe. Large knowledge gaps regarding the biological characteristics of viral structural proteins have severel...