Molecular characterization of the permanent outer-inner membrane contact site of the mitochondrial genome segregation complex in trypanosomes [0.03%]
血吸虫线粒体基因组分离复合物的永久性外内膜接触位点的分子特征刻画
Philip Stettler,Bernd Schimanski,Salome Aeschlimann et al.
Philip Stettler et al.
The parasitic protozoan Trypanosoma brucei has a single unit mitochondrial genome linked to the basal body of the flagellum via the tripartite attachment complex (TAC). The TAC is crucial for mitochondrial genome segregation during cytokine...
A zebrafish-based in vivo model of Zika virus infection unveils alterations of the glutamatergic neuronal development and NS4A as a key viral determinant of neuropathogenesis [0.03%]
寨卡病毒的斑马鱼感染模型揭示了神经发育中谷氨酸能神经元的变化以及NS4A是神经毒性的关键因素
Aïssatou Aïcha Sow,Priyanka Jamadagni,Pietro Scaturro et al.
Aïssatou Aïcha Sow et al.
Infection of pregnant women by Zika virus (ZIKV) is associated with severe neurodevelopmental defects in newborns through poorly defined mechanisms. Here, we established a zebrafish in vivo model of ZIKV infection to circumvent limitations ...
Serotype switching in Pseudomonas aeruginosa ST111 enhances adhesion and virulence [0.03%]
潘氏克菌ST111型别转换增强黏附和毒力
Mikkel Anbo,Mahbuba Akter Lubna,Dina A Moustafa et al.
Mikkel Anbo et al.
Evolution of the highly successful and multidrug resistant clone ST111 in Pseudomonas aeruginosa involves serotype switching from O-antigen O4 to O12. How expression of a different O-antigen serotype alters pathogen physiology to enable glo...
Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune response [0.03%]
新型冠状病毒核衣壳蛋白通过增强p-PKCα与RACK1的结合来抑制核酸胞质运输和干扰固有免疫反应
Wenxiang Xue,Hongyan Chu,Jiehuang Wang et al.
Wenxiang Xue et al.
The hallmark of coronavirus infection lies in its ability to evade host immune defenses, a process intricately linked to the nuclear entry of transcription factors crucial for initiating the expression of antiviral genes. Central to this ev...
Human norovirus disturbs intestinal motility and transit time through its capsid proteins [0.03%]
人类诺如病毒通过其衣壳蛋白干扰肠道运动和转运时间
Arno Cuvry,Lorane Molineaux,Roberto Gozalbo-Rovira et al.
Arno Cuvry et al.
Human norovirus (HuNoV) accounts for over 700 million cases of gastroenteritis annually. Episodes of HuNoV disease are characterized by vomiting and diarrhea as the two most prominent symptoms. Despite its prevalence, our understanding of t...
Discovery of Nanosota-9 as anti-Omicron nanobody therapeutic candidate [0.03%]
纳米抗体Nanosota-9可作为治疗奥密克戎等新冠病毒的候选药物
Gang Ye,Fan Bu,Divyasha Saxena et al.
Gang Ye et al.
Omicron subvariants of SARS-CoV-2 continue to pose a significant global health threat. Nanobodies, single-domain antibodies derived from camelids, are promising therapeutic tools against pandemic viruses due to their favorable properties. I...
Viral genomic methylation and the interspecies evolutionary relationships of ranavirus [0.03%]
兰病毒基因组甲基化及其种间进化关系研究
Weiqiang Pan,Mincong Liang,Yanlin You et al.
Weiqiang Pan et al.
Ranaviruses are capable of infecting both wild and farmed fish, amphibians, and reptiles, leading to significant economic losses and ecological risks. Currently, ranaviruses have been found in at least 175 species spanning six continents. E...
Trim72 is a major host factor protecting against lethal Candida albicans infection [0.03%]
Trim72是抵抗致死白色念珠菌感染的主要宿主因子
Wang Tan,Jiayu Liu,Renlin Yu et al.
Wang Tan et al.
Candida albicans is the most common aetiologic pathogen of fungal infections associated with high mortality in immunocompromised patients. There is an urgent need to develop new antifungal therapies owing to the poor efficacy and resistance...
Membrane fluidity control by the Magnaporthe oryzae acyl-CoA binding protein sets the thermal range for host rice cell colonization [0.03%]
稻瘟菌酰基辅酶A结合蛋白控制的膜流动性调节决定了其感染寄主水稻细胞的温度范围
Michael Richter,Lauren M Segal,Raquel O Rocha et al.
Michael Richter et al.
Following leaf cuticle penetration by specialized appressorial cells, the devastating blast fungus Magnaporthe oryzae grows as invasive hyphae (IH) in living rice cells. IH are separated from host cytoplasm by plant-derived membranes formin...
Examining the molecular clock hypothesis for the contemporary evolution of the rabies virus [0.03%]
检验狂犬病病毒当代进化分子钟假说
Rowan Durrant,Christina A Cobbold,Kirstyn Brunker et al.
Rowan Durrant et al.
The molecular clock hypothesis assumes that mutations accumulate on an organism's genome at a constant rate over time, but this assumption does not always hold true. While modelling approaches exist to accommodate deviations from a strict m...