Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates [0.03%]
肥胖对非人灵长类动物SARS-CoV-2感染的急性反应和COVID-19后期综合症(PASC)发展的影响
Kristin A Sauter,Gabriela M Webb,Lindsay Bader et al.
Kristin A Sauter et al.
Long-term adverse consequences of SARS-CoV-2 infection, termed "long COVID" or post-acute sequelae of COVID (PASC), are a major component of overall COVID-19 disease burden. Prior obesity and metabolic disease increase the severity of acute...
Redefining the spliceosomal introns of the sexually transmitted parasite Trichomonas vaginalis and its close relative in columbid birds [0.03%]
解剖并定义感染人类的寄生虫阴道毛滴虫及其鸟类近亲的剪接体内含子
Francisco Callejas-Hernández,Mari Shiratori,Steven A Sullivan et al.
Francisco Callejas-Hernández et al.
Trichomonas vaginalis infects the urogenital tract of men and women and causes the sexually transmitted infection trichomoniasis. Since the publication of its draft genome in 2007, the genome has drawn attention for several reasons, includi...
A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: Unveiling a novel virulence factor [0.03%]
感染性喉气管炎病毒基因组编码一个功能性的白细胞介素-4同源物：揭示一个新的毒力因子
Jeremy D Volkening,Stephen J Spatz,Maricarmen Garcia et al.
Jeremy D Volkening et al.
Herpesviruses have evolved numerous immune evasion tactics, persisting within their hosts through self-perpetuating strategies. One such tactic involves acquiring functional copies of host genes encoding cytokines such as IL-6 (HHV-8), IL-1...
Lumpy skin disease virus 001/156 protein is a virulence factor that suppresses interferon production through impairing IRF3 dimerization [0.03%]
病毒蛋白001/156通过破坏IRF3二聚化抑制干扰素产生并为致病因子
Minmin Zhang,Yujie Shi,Xinyin Lu et al.
Minmin Zhang et al.
Lumpy skin disease virus (LSDV), a member of the genus Capripoxvirus within the family Poxviridae, causes significant disease in cattle and is classified as a notifiable disease by the World Organization for Animal Health (WOAH). The virus ...
A chaperonin complex regulates organelle proteostasis in malaria parasites [0.03%]
伴侶蛋白復合物調節瘧原蟲細胞器穩態
Amanda Tissawak,Yarden Rosin,Shirly Katz Galay et al.
Amanda Tissawak et al.
The apicoplast of Plasmodium parasites serves as a metabolic hub that synthesize essential biomolecules. Like other endosymbiotic organelles, 90% of the apicoplast proteome is encoded by the cell nucleus and transported to the organelle. Ev...
Through thick and thin: The vaginal microbiome as both occupant and healer [0.03%]
共克时艰：阴道微生物组既是居住者也是治愈者
Mart Sillen,Sarah Lebeer,Patrick Van Dijck
Mart Sillen
Oligomerization of the Clostridioides difficile transferase B component proceeds through a stepwise mechanism [0.03%]
难辨梭菌转移动物素酶B亚基的寡聚化通过逐步机制进行
Robin M Mullard,Michael J Sheedlo
Robin M Mullard
Clostridioides difficile is a gram-positive, pathogenic bacterium and is currently the leading cause of hospital-acquired, infectious diarrhea in the United States. During infection, C. difficile produces and secretes up to three toxins cal...
Specific binding of human P[28] rotavirus VP8* protein to blood group ABH antigens on type 1 chains [0.03%]
人P[28]轮状病毒VP8*蛋白与血型ABH抗原中类型1链的特异性结合
Yi Zheng,Xiaoman Sun,Yuting Li et al.
Yi Zheng et al.
Group A rotavirus (RV) has been the major cause of acute gastroenteritis in infants and young children. Among the five P genogroups almost all P genotype RVs in P[II], P[III] and P[IV] genogroups that infect humans can bind glycan histo-blo...
Early-life RSV infection modulates innate immune events, preferentially enhancing allergen-induced type 2 lung inflammation in females [0.03%]
生命早期RSV感染调节先天免疫事件，优先增强女性过敏原诱导的2型肺部炎症反应
Lydia Labrie,Rojine C McVea,Rami Karkout et al.
Lydia Labrie et al.
Respiratory syncytial virus (RSV) causes millions of hospitalizations and thousands of deaths per year globally. Early-life RSV infection is also associated with the subsequent development of wheezing and asthma, which exhibits sex-related ...
Jessica M Porter,Kaitlin R Hulce,Mackenzi S Oswald et al.
Jessica M Porter et al.
Antiviral immunity compromises the efficacy of adeno-associated virus (AAV) vectors used for gene therapy. This is well understood for the adaptive immune response. However, innate immune effectors like alpha-defensin antimicrobial peptides...