SARS-CoV-2 infection of salivary glands compromises the production of a secreted antifungal peptide with potential implications for development of oral candidiasis [0.03%]
新型冠状病毒感染唾液腺可能会损害一种抗菌肽的产生，或导致念珠菌病发展风险增加
Areej A Alfaifi,Tristan W Wang,Paola Perez et al.
Areej A Alfaifi et al.
Saliva contains antimicrobial peptides considered integral components of host innate immunity, and crucial for protection against colonizing microbial species. Most notable is histatin-5 which is exclusively produced in salivary glands with...
Seasonal influenza a virus lineages exhibit divergent abilities to antagonize interferon induction and signaling [0.03%]
甲型流感病毒谱系分化出干扰素诱导和信号传导的拮抗能力
Joel Rivera-Cardona,Neeha Kakuturu,Elizabeth F Rowland et al.
Joel Rivera-Cardona et al.
The circulation of seasonal influenza A viruses (IAVs) in humans relies on effective evasion and subversion of the host immune response. While the evolution of seasonal H1N1 and H3N2 viruses to avoid humoral immunity is well characterized, ...
Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice [0.03%]
病毒性微小核糖核酸对Akt的调控对于人巨细胞病毒由休眠状态复活为复制型是必需的：CD34⁺造血前体细胞和人类免疫系统嵌合小鼠模型研究
Nicole L Diggins,Andrew H Pham,Jennifer Mitchell et al.
Nicole L Diggins et al.
Human cytomegalovirus (HCMV) actively manipulates cellular signaling pathways to benefit viral replication. Phosphatidyl-inositol 3-kinase (PI3K)/Akt signaling is an important negative regulator of HCMV replication, and during lytic infecti...
Is metabolic generalism the Breakfast of Champions for pathogenic Candida species? [0.03%]
代谢通用性是致病性念珠菌的冠军早餐吗？
Delma S Childers,Jane Usher
Delma S Childers
Polyfunctionality and breadth of HIV-1 antibodies are associated with delayed disease progression [0.03%]
广谱HIV-1抗体与艾滋病延迟发病相关
Marloes Grobben,Margreet Bakker,Angela I Schriek et al.
Marloes Grobben et al.
HIV-1 infection leads to chronic disease requiring life-long treatment and therefore alternative therapeutics, a cure and/or a protective vaccine are needed. Antibody-mediated effector functions could have a role in the fight against HIV-1....
Retraction: Oxidation of Helix-3 Methionines Precedes the Formation of PK Resistant PrPSc [0.03%]
撤回：Helix-3甲硫氨酸氧化先于PK抗性PrPSc的形成
PLOS Pathogens Editors
PLOS Pathogens Editors
Retraction of Publication
PLoS pathogens. 2024 Dec 11;20(12):e1012775. DOI:10.1371/journal.ppat.1012775 2024
Retraction: Fatal Prion Disease in a Mouse Model of Genetic E200K Creutzfeldt-Jakob Disease [0.03%]
撤稿：遗传性E200K克雅病小鼠模型中的致死性朊病毒病
PLOS Pathogens Editors
PLOS Pathogens Editors
Retraction of Publication
PLoS pathogens. 2024 Dec 11;20(12):e1012774. DOI:10.1371/journal.ppat.1012774 2024
Rebeca Benavente,Rodrigo Morales
Rebeca Benavente
Jeremy R Keown,Loïc Carrique,Benjamin E Nilsson-Payant et al.
Jeremy R Keown et al.
Hantaviridae are a family of segmented negative-sense RNA viruses that contain important human and animal pathogens. Hantaviridae contain a viral RNA-dependent RNA polymerase that replicates and transcribes the viral genome. Here we establi...
Fatal Lassa fever in cynomolgus monkeys is associated with systemic viral dissemination and inflammation [0.03%]
导致长尾猕猴发生致命拉萨热与全身病毒扩散和炎症反应有关
Jimmy Hortion,Emeline Perthame,Blaise Lafoux et al.
Jimmy Hortion et al.
The pathogenesis of Lassa fever has not yet been fully deciphered, particularly as concerns the mechanisms determining whether acute infection is controlled or leads to catastrophic illness and death. Using a cynomolgus monkey model of Lass...