Infection with Mycobacterium tuberculosis alters the antibody response to HIV-1 [0.03%]
结核分枝杆菌感染改变人类免疫缺陷病毒-1的抗体反应
Marius Zeeb,Katharina Kusejko,Sonja Hartnack et al.
Marius Zeeb et al.
Background: Co-infection with Mycobacterium tuberculosis (MTB) differentially modulates untreated HIV-1 infection, with asymptomatic MTB reducing HIV-1 viremia and opportunistic infections and active tuberculosis (TB) acc...
ERK-METTL3 axis acts as a novel regulator of antiviral innate immunity combating pseudorabies virus infection [0.03%]
ERK-METTL3轴是抗伪狂犬病毒先天免疫反应的新调节因子
Lucai Wang,Xiangqi Qiu,Lele Wang et al.
Lucai Wang et al.
The ERK-mediated phosphorylation of the core m6A methyltransferase METTL3 has been linked to the regulation of embryonic stem cell differentiation and tumorigenesis. However, its role in the antiviral innate immune response remains unclear....
Dunia Asensio-Cob,Carlos P Mata,Josue Gomez-Blanco et al.
Dunia Asensio-Cob et al.
The infectivity of rotavirus (RV), the leading cause of childhood diarrhea, hinges on the activation of viral particles through the proteolysis of the spike protein by trypsin-like proteases in the host intestinal lumen. In order to determi...
Yersinia actively downregulates type III secretion and adhesion at higher cell densities [0.03%]
耶尔森菌在细胞密度较高时主动下调III型分泌和黏附
Francesca Ermoli,Gabriele Malengo,Christoph Spahn et al.
Francesca Ermoli et al.
The T3SS injectisome is used by Gram-negative bacteria, including important pathogens, to manipulate eukaryotic target cells by injecting effector proteins. While in some bacterial species, T3SS-negative bacteria benefit from the activity o...
Transcriptome profiling of L. infantum-infected human macrophages reveals sex-specific type I interferon induction [0.03%]
利什曼原虫感染的人巨噬细胞转录组分析揭示性别特异性I型干扰素诱导现象
Annika Bea,Helena Fehling,Fabian Hausmann et al.
Annika Bea et al.
Sex-based differences in the immune system influence the clinical course of infectious diseases, including many parasitic infections. Field studies of human infections and controlled experimental rodent models have shown that certain clinic...
Age-associated immune dysregulation and B cell dysfunction drive severe outcomes in SFTSV infection [0.03%]
年龄相关的免疫调节异常和B细胞功能障碍导致SFTSV感染的严重后果
Eun-Ha Kim,Ho Bin Jang,Se-Mi Kim et al.
Eun-Ha Kim et al.
Aging significantly influences host immune responses to viral infections, including Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), which is associated with high mortality in elderly patients. Despite its high fatality rate and p...
A hypovirulence-associated capsidless bi-segmented ssRNA mycovirus enhances melanin and microsclerotial production in a vascular phytopathogenic fungus [0.03%]
一种低毒力无衣壳双分段正链ssRNA真菌病毒促进土壤习居型植物病原真菌黑色素和微菌核产生的机制研究
Jiamin Gao,Xuekun Zhang,Jichun Jia et al.
Jiamin Gao et al.
Mycoviruses are increasingly recognized for their multifaceted roles in fungal ecology, because of advances in understanding of their biology and molecular features. In this research, we identified and characterized two capsidless, bi-segme...
Kayla F Reddy,Aleksey Prok,Corinne M Stouthamer et al.
Kayla F Reddy et al.
Plants and fungi often produce toxic metabolites, but herbivores and fungivores that evolve resistance to these toxins gain access to underutilized resources. An additional benefit of living in and consuming toxins is that animals can gain ...
Animal models of Mycobacterium abscessus pulmonary infection phenotypes: What are we modeling? [0.03%]
表型动物模型模拟胞壁缺损分枝杆菌肺部感染的思考
Xiangyu Sui,Stefan H Oehlers
Xiangyu Sui
Inactivation of branched-chain amino acid uptake halts Staphylococcus aureus growth and induces bacterial quiescence within macrophages [0.03%]
支链氨基酸摄取失活可阻止金黄色葡萄球菌生长并在巨噬细胞内诱导细菌休眠状态
Adriana Moldovan,Ronald S Flannagan,Marcel Rühling et al.
Adriana Moldovan et al.
Staphylococcus aureus is a notorious human pathogen that thrives in macrophages. It resides in mature phagolysosomes, where a subset of the bacteria eventually begin to proliferate. How S. aureus acquires essential nutrients, such as amino ...