Persistent type I interferon signaling within the brain of people with HIV on ART with cognitive impairment [0.03%]
持续接受抗逆转录病毒治疗且存在认知障碍的HIV感染者大脑中I型干扰素信号转导异常
Yuyang Tang,Ling Xie,Ciniso Sylvester Shabangu et al.
Yuyang Tang et al.
To better understand the molecular mechanism that drives neuroinflammation, we analyzed the protein profiles of 27 brains from HIV with HIV (PWH) on antiretroviral therapy (ART), including various stages of HIV-associated neurocognitive dis...
Rice ragged stunt virus Pns10 induces mitochondrial-mediated apoptosis to promote viral infection in Nilaparvata lugens through disrupting the NlNDUFS1-NlPHB2 interaction [0.03%]
水稻条纹病毒诱导褐飞虱线粒体介导的细胞凋亡促进其增殖感染
Lianshun Zheng,Shuai Fu,Ming Zeng et al.
Lianshun Zheng et al.
Apoptosis, a programmed cell death process, plays crucial roles in host antiviral response. Although there are many reports on the relationship between cell apoptosis and viral infection, the mechanisms underlying plant arbovirus-induced ap...
The pUL47 tegument protein of Marek's Disease Virus interacts with p32/C1QBP to promote horizontal transmission [0.03%]
马立克氏病病毒的pUL47衣壳蛋白通过与p32/C1QBP相互作用来促进水平传播
Mallorie Durand,Aurélien Chuard,Sylvie Rémy et al.
Mallorie Durand et al.
Inter-individual transmission is an essential part of viruses' life cycle, yet the molecular basis of transmission remains elusive. Using Marek's Disease Virus (MDV), a deadly and contagious herpesvirus of chickens that is transmitted by in...
Mobilization of nuclear antiviral factors by exportin XPO1 via the actin network inhibits RNA virus replication [0.03%]
通过出口蛋白XPO1利用肌动蛋白网络动员核抗病毒因子可抑制RNA病毒复制
Biao Sun,Cheng-Yu Wu,Paulina Alatriste Gonzalez et al.
Biao Sun et al.
The intricate interplay between +RNA viruses and their hosts involves the exploitation of host resources to build virus-induced membranous replication organelles (VROs) in cytosol of infected cells. Previous genome- and proteome-wide approa...
An invertebrate NLR recognizes viral nucleic acids and balances the antiviral signaling pathway through interaction with STING and Cyclophilin A [0.03%]
无脊椎动物NLR通过与STING和环素A的互作识别病毒核酸并通过调控抗病毒信号通路平衡免疫反应
Shihao Li,Xuechun Li,Mingzhe Sun et al.
Shihao Li et al.
Intracellular recognition of viral nucleic acids by NLRs and subsequent activation of antiviral immunity are proved to be crucial for host defense against virus infection in vertebrates. However, understanding on these processes is very lim...
Pattern recognition receptor-associated immuno-thrombotic transcript changes in platelets and leukocytes with COVID19 [0.03%]
与COVID-19相关的血小板和白细胞中模式识别受体相关免疫凝血转录变化
Heather Learnard,Jason Core,Heather Corkrey et al.
Heather Learnard et al.
Respiratory infections are characterized by an increased risk of thrombosis, likely involving platelet-leukocyte crosstalk via pattern recognition receptors (PRRs). Here we characterized COVID19-mediated changes in PRR levels and their asso...
LANA-dependent transcription-replication conflicts and R-loops at the terminal repeats (TR) correlate with KSHV episome maintenance [0.03%]
LANA介导的转录-复制冲突以及末端重复序列（TR）处的R-loop与KSHV潜伏感染相关
Asim Asghar,Olga Vladimirova,Asher Sobotka et al.
Asim Asghar et al.
Transcription-replication conflicts frequently occur at repetitive DNA elements involved in genome maintenance functions. The KSHV terminal repeats (TR) function as the viral episome maintenance element when bound by the viral encoded nucle...
Adeno-Associated Virus 2 (AAV2) - Induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression [0.03%]
腺相关病毒2型（AAV2）诱导的RPA耗尽导致细胞DNA损伤并限制病毒基因表达
Monnette F Summers,MegAnn K Haubold,Marcel Morgenstern et al.
Monnette F Summers et al.
Parvoviruses are single-stranded DNA viruses that have been modified to serve as vehicles for therapeutic transgene delivery in the form of recombinant Adeno-Associated Virus (rAAV2) vectors or rodent parvovirus-derived oncolytic agents. In...
Germinal Center B cells provide essential IL-1β signals to TFH cells via canonical NLRP3 inflammasome activity post influenza infection [0.03%]
生后流感感染期间，生发中心B细胞通过经典NLRP3炎性小体活化为TFH细胞提供必要的IL-1β信号
Juliana Restrepo Munera,Cainan Riccio-Baum,Rebecca Kaddis Maldonado et al.
Juliana Restrepo Munera et al.
Persistent germinal center (GC) responses show increased benefit in optimal responses to influenza infection. Follicular helper T (TFH) cells provide the essential signals and help for maintenance of GCs and require IL-1β signaling for est...
Pore-C sequencing identifies episome-driven chromosome conformation perturbations differentiating pneumococcal epigenetic variantsh [0.03%]
利用孔隙序列识别肺炎链球菌表观遗传变异体的质粒驱动染色体构象扰动
Tze Yee Lim,Samuel T Horsfield,Catherine M Troman et al.
Tze Yee Lim et al.
Streptococcus pneumoniae (pneumococcus) is a genetically diverse opportunistic bacterial pathogen that expresses two phase-variable loci encoding restriction-modification systems. Comparisons of two genetically-distinct pairs of epigenetica...