Human papillomavirus genomes associate with active host chromatin during persistent viral infection [0.03%]
人乳头瘤病毒基因组在持续性病毒感染过程中与活跃的宿主染色质相关联
Alix Warburton,Tovah E Markowitz,J J L Miranda et al.
Alix Warburton et al.
Human papillomaviruses (HPVs) maintain their genomes as minichromosomes in the nuclei of infected keratinocytes. This study investigates the association of HPV31 genomes with host chromatin using both HiC and 4C-seq chromosome conformation ...
Spatiotemporal coordination of reovirus peripheral core replication to perinuclear whole virus assembly [0.03%]
呼肠孤病毒外周核心区复制与全病毒包涵体内的核周装配的时空协调性
Justine Kniert,Dante Terino,Heather E Eaton et al.
Justine Kniert et al.
Reoviruses coordinate their replication and assembly through intricate spatial and temporal compartmentalization within host cells. In this study, we elucidate the dynamics of mammalian orthoreovirus (reovirus) core replication and viral pa...
A divergent cyclic nucleotide binding protein promotes Plasmodium ookinete infection of the mosquito [0.03%]
一个非共识型环核苷酸结合蛋白能促进疟原虫在蚊体内的子孢子感染
Dominika Kwecka,Zhishuo Wang,Edvardas Eigminas et al.
Dominika Kwecka et al.
Colonisation of mosquitos by the malarial parasite is critically reliant on the invasive ookinete stage. Ookinete invasion of mosquito is coordinated by the apical complex, a specialised parasite structure containing components for secretio...
Newcastle disease virus promotes spreading infection through vimentin-dependent tight junction injury mediated by MLC/p-MLC activation [0.03%]
新城疫病毒感染通过MLC/p-MLC活化介导的波形蛋白依赖性紧密连接损伤促进扩散感染
Xiaolong Lu,Qiwen Zhou,Mingzhu Wang et al.
Xiaolong Lu et al.
Newcastle disease virus (NDV), a widespread poultry pathogen, spreads efficiently via the respiratory tract. However, the precise mechanism governing its spreading infection remains unclear. This study reveals that NDV-induced tight junctio...
The multifaceted role of the viral 2A protease in enterovirus replication and antagonism of host antiviral responses [0.03%]
病毒2A蛋白酶在肠道病毒复制和拮抗宿主抗病毒反应中的多面作用
Jelle G Schipper,Chiara Aloise,Sereina O Sutter et al.
Jelle G Schipper et al.
Enteroviruses dramatically remodel the cellular infrastructure for efficient replication and curtailing host antiviral responses. The roles of viral proteins in these processes have been studied mostly in vitro, by ectopic overexpression, o...
Correction: Gene deletion as a possible strategy adopted by New World Leishmania infantum to maximize geographic dispersion [0.03%]
订正：新世界婴儿利什曼原虫可能采用基因缺失策略以最大限度地扩大地理分布
Monique Florêncio,Marne Coimbra Batalha Chagas,Anderson Guimarães-Costa et al.
Monique Florêncio et al.
[This corrects the article DOI: 10.1371/journal.ppat.1012938.]. Copyright: © 2025 Florêncio et al. This is an open access article distributed under the...
Published Erratum
PLoS pathogens. 2025 Aug 28;21(8):e1013452. DOI:10.1371/journal.ppat.1013452 2025
Retraction: Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease [0.03%]
撤稿：健康和HIV感染期间淋巴组织中细胞溶解性CD4+T细胞的有限免疫监视作用
PLOS Pathogens Editors
PLOS Pathogens Editors
Schistosoma japonicum leishmanolysin SjLLPi1 facilitates the invasion of cercariae into the host skin [0.03%]
日本血吸虫裂殖体入侵宿主皮肤时释放的溶酶体蛋白SjLLPi1的作用机制研究
Fanyan Chen,Bingkuan Zhu,Yu Fang et al.
Fanyan Chen et al.
Background: Schistosomiasis is an important neglected tropical disease necessitating focus. Cercarial proteases are essential for schistosome invasion. Leishmanolysin has been identified as the most predominant protease i...
Differential tropisms of old and new world hantaviruses influence virulence and developing host-directed antiviral candidates [0.03%]
旧大陆和新大陆汉坦病毒的不同趋向性影响毒力及开发宿主导向型抗病毒候选药物
Arjit Vijey Jeyachandran,Joseph Ignatius Irudayam,Swati Dubey et al.
Arjit Vijey Jeyachandran et al.
Hantaviruses are zoonotically transmitted from rodents to humans through the respiratory route, with no currently approved antivirals or widely available vaccines. The recent discovery of interhuman-transmitted Andes virus (ANDV) necessitat...
Gap-free comparative genomics uncover virulence factors for Fusarium wilt of watermelons [0.03%]
无间隙比较基因组学揭示西瓜枯萎病致病因素相关毒性因子
Dilay Hazal Ayhan,Huan Wang,Lili Zhang et al.
Dilay Hazal Ayhan et al.
Watermelon (Citrullus lanatus L.) is a globally important fruit crop, yet it is susceptible to devastating diseases such as vascular wilt caused by Fusarium oxysporum f. sp. niveum (Fon), with limited control options. Fon rapidly evolves to...