Qian Wang,Zichao Peng,Bin Gui et al.
Qian Wang et al.
Grass carp reovirus (GCRV) causes hemorrhagic disease and substantial economic losses in the aquaculture of grass carp (Ctenopharyngodon idella), a commercially important fish species in China. Although viral entry depends on interactions b...
Mycobacterium tuberculosis impairs protective cytokine production via transcription factor MafB manipulation [0.03%]
结核分枝杆菌通过调节转录因子MafB削弱保护性细胞因子的产生
Hiroyuki Saiga,Masaki Ueno,Toshiki Tamura et al.
Hiroyuki Saiga et al.
Although an increased expression of the transcription factor v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) has been reported in patients with active tuberculosis (TB), its potential role in Mycobacterium tuberculosis...
Structure-function studies of Vibrio cholerae quorum-sensing receptor CqsR signal recognition [0.03%]
霍乱弧菌群体感应受体CqsR信号识别的结构功能研究
Andrew M Guarnaccia,Anjali D Steenhaut,Sandra D Olenic et al.
Andrew M Guarnaccia et al.
Ethanolamine signaling through the transmembrane quorum-sensing receptor CqsR influences Vibrio cholerae niche recognition and host colonization. In this study, we present a comprehensive structure-function analysis of CqsR. Specifically, w...
Intracellular formate modulates a motility-invasion switch in Salmonella Typhimurium [0.03%]
细胞内甲酸盐可调节伤寒沙门氏菌的运动-侵袭开关
Debapriya Mukherjee,Salik Noor,Tamoghna Mukherjee et al.
Debapriya Mukherjee et al.
Host-derived short-chain fatty acids (SCFAs) are essential for Salmonella Typhimurium (STM) virulence. Formate, an SCFA found in the ileum, enhances STM invasion, but the role of the intracellular formate pool in STM pathogenesis remains po...
A close unicellular animal relative and predator of schistosomes exhibits chemokinesis in response to proteins and peptides from its prey [0.03%]
一种与血吸虫亲近的单细胞动物及其天敌对猎物蛋白和肽的化学趋向运动响应
Soniya R Quick,Jason S Bains,Catherine Gerdt et al.
Soniya R Quick et al.
Regulated motility is vital for many cells-both for unicellular microbes and for cells within multicellular bodies. Different conditions require different rates and directions of movement. For the microbial predator Capsaspora owczarzaki, i...
The PP2A-2 holoenzyme orchestrates daughter cell emergence during cytokinesis in Toxoplasma gondii [0.03%]
顶体虫属托拉丝包虫病菌二聚体蛋白磷酸酶2A-2调控有丝分裂胞质分离过程中的子代细胞出现事件
Jin-Lei Wang,Meng Wang,Nian-Zhang Zhang et al.
Jin-Lei Wang et al.
Toxoplasma gondii is a significant pathogen in both humans and animals, with disease progression driven by the rapid proliferation of its tachyzoite stage. In this study, we identify the PP2A-2 holoenzyme as a key regulator of daughter cell...
Versatile roles of rubredoxin reductase of Pseudomonas aeruginosa TBCF10839 in virulence and stress protection [0.03%]
铜绿假单胞菌TBCF10839中rubredoxin还原酶在致病性和抗逆境中的多功能作用
Lutz Wiehlmann,Thorsten Adams,Claus Urbanke et al.
Lutz Wiehlmann et al.
Many microorganisms can degrade alkanes, using them as carbon source. The first and key step in alkane utilization is its hydroxylation, which requires a catalytic membrane-bound monooxygenase, a soluble rubredoxin and a soluble rubredoxin ...
HIV-1 accessory protein Vpr possesses a cryptic p300-dependent transcription-promoting activity that is blocked by histone deacetylases in CD4+ T cells [0.03%]
HIV-1辅助蛋白Vpr具有隐秘的转录促进活性，该活性由CD4+T细胞中的p300激活且被组蛋白去乙酰化酶抑制
Catherine A Lewis,David M Margolis,Edward P Browne
Catherine A Lewis
Antiretroviral therapy (ART) has dramatically improved the clinical prognosis for people with HIV and prevents HIV transmission. However, ART does not cure HIV infection because of a persistent, latent viral reservoir in long-lived cells su...
Glycosylphosphatidylinositol biosynthesis functions as a conserved host defense pathway against coronaviruses via regulation of LY6E [0.03%]
糖基磷脂酰肌醇生物合成通过调节LY6E作为宿主抗冠状病毒的保守防御途径发挥作用
Yanlong Ma,Fei Feng,Hui Feng et al.
Yanlong Ma et al.
Coronaviruses, including SARS-CoV-2, rely on host factors for their replication and pathogenesis, while hosts deploy defense mechanisms to counteract viral infections. Although numerous host proviral factors have been identified, the landsc...
Identification of a Kingella kingae factor H binding protein that is the major determinant of serum resistance [0.03%]
识别出一Kingella kingae结合蛋白因子H主要决定血清抗性
Kevin A Hernandez,Eric A Porsch,Vanessa L Muñoz et al.
Kevin A Hernandez et al.
Kingella kingae is a Gram-negative bacterium that has emerged as a leading cause of invasive disease in children between 6 months and 4 years of age. K. kingae initiates infection by colonizing the oropharynx, then breaches the oropharyngea...