Identification and antiviral mechanism of a novel chicken-derived interferon-related antiviral protein targeting PRDX1 [0.03%]
一种新型鸡源性干扰素抗病毒蛋白的鉴定及其对PRDX1的作用识别与抗病毒机制研究
Jing Chen,Peiheng Li,Letian Li et al.
Jing Chen et al.
In this study, we identified a new chicken-specific protein, named chicken interferon-related antiviral protein (chIRAP) after sequence analysis and comparison, which inhibited the proliferation of various viruses including influenza A viru...
A dual interaction between RSV NS1 and MED25 ACID domain reshapes antiviral responses [0.03%]
RSV NS1与MED25酸性区域的相互作用重塑抗病毒反应
Celia Ait-Mouhoub,Jiawei Dong,Magali Noiray et al.
Celia Ait-Mouhoub et al.
Respiratory syncytial virus (RSV), the most common cause of bronchiolitis and pneumonia in infants, elicits a remarkably weak innate immune response. This is partly due to type I interferon (IFN) antagonism by the non-structural RSV NS1 pro...
Discovery and mechanistic insights of dibenzoylmethane as a broad spectrum inhibitor of coronavirus [0.03%]
茋类衍生物二苯甲酮茋是一种广谱冠状病毒抑制剂及其作用机制研究
Yuan Sun,Xiaoyang Shu,Lu Chen et al.
Yuan Sun et al.
Coronavirus, a large family of positive-sense RNA viruses, are responsible for both mild and severe respiratory illnesses, ranging from the common cold to life-threatening conditions. Despite significant advances in vaccine and antiviral de...
Hnf4α integrates AIF and caspase 3/9 signaling to restrict single and coinfecting pathogens in teleosts [0.03%]
HNF4α整合AIF和caspase 3/9信号以限制硬骨鱼中的单一生物和共生生物入侵
Dong Yan,Min Hui Tao,Xiao Man Wu et al.
Dong Yan et al.
Hepatocyte nuclear factor 4 alpha (Hnf4α), a conserved nuclear receptor central to vertebrate liver development and metabolic regulation, emerges here as a pivotal immune regulator in teleosts against complex infectious threats. While its ...
Chenxi Wang,Yubin Xie,Weixin Li et al.
Chenxi Wang et al.
Zika virus (ZIKV) has emerged as a rising concern in global health in recent years. The role of PD-1/PD-L1 immune checkpoint in acute ZIKV infection remains to be understood. In this study we demonstrated the activation of PD-1/PD-L1 immune...
Immune signatures of SARS-CoV-2 infection resolution in human lung tissues [0.03%]
人肺组织中SARS-CoV-2感染消退的免疫特征
Devin Kenney,Aoife K O&#x;Connell,Anna E Tseng et al.
Devin Kenney et al.
While human autopsy samples have provided insights into pulmonary immune mechanisms associated with severe viral respiratory diseases, the mechanisms that contribute to a clinically favorable resolution of viral respiratory infections remai...
Gauthier Lieber,Florence Kwaschik,Marie Lork et al.
Gauthier Lieber et al.
SUMO-modified Tripartite Motif Protein 28 (TRIM28; KAP1) plays a crucial role in repressing endogenous retroelement (ERE) transcription. We previously provided evidence that loss of SUMO-modified TRIM28 triggered by influenza A virus (IAV) ...
Receptor transporter protein 4 (RTP4)-mediated repression of hepatitis C virus replication in mouse cells [0.03%]
受体转运蛋白4(RTP4)介导的小鼠细胞内丙型肝炎病毒复制的抑制作用
Michael P Schwoerer,Sebastian Carver,Aaron E Lin et al.
Michael P Schwoerer et al.
Hepatitis C virus (HCV) exhibits a narrow species tropism, causing robust infections only in humans and experimentally inoculated chimpanzees. While many host factors and restriction factors are known, many more likely remain unknown, which...
Divergent resistance pathways amongst SARS-CoV-2 PLpro inhibitors highlight the need for scaffold diversity [0.03%]
不同的SARS-CoV-2 PLpro抑制剂抗药性途径表明需要支架多样性
Xinyu Wu,Shane M Devine,Margareta Go et al.
Xinyu Wu et al.
Drug-escape, where a target evolves to escape inhibition from a drug, has the potential to lead to cross-resistance where drugs that are structurally related or share similar binding mechanisms all become less effective. PLpro inhibitors ar...
Genome-wide phenotypic insights into mycobacterial virulence using Drosophila melanogaster [0.03%]
利用果蝇(Drosophila melanogaster)获得分枝杆菌毒力的基因组表型新见解
Niruja Sivakumar,Esther Fuentes,Linn-Karina Selvik et al.
Niruja Sivakumar et al.
Drosophila melanogaster (Drosophila) is one of the most extensively studied animal models we have, with a broad, advanced, and organized research community. Yet, Drosophila has barely been exploited to understand the underlying mechanisms o...