Cross-kingdom dialogs in the gut: Integrating bacterial pathogens, helminths, and microbiota interactions for immune homeostasis [0.03%]
跨界对话：肠道内细菌病原体、蠕虫和微生物群相互作用的整合以维持免疫平衡
Suhui Hu,Zhenzhen Liu,Wenchao Yan et al.
Suhui Hu et al.
The interactions between bacterial pathogens, helminths, and commensal microbiota in the gut form a complex ecological network that profoundly impacts host immunity and health. Pathogens employ strategies such as type VI secretion systems (...
Dendritic cells and HIV transmission: roles and subsets of antigen-presenting cells in the human anogenital tract [0.03%]
树突细胞和HIV传播：人类肛生殖道抗原呈递细胞的作用及亚群
Daniel J Buffa,Thomas R O&#x;Neil,Erica E Vine et al.
Daniel J Buffa et al.
Dendritic cells (DCs) are potent antigen-presenting cells and play a key role in facilitating the sexual transmission of HIV, functioning as a delivery system responsible for trafficking the virus from exposed barrier sites to their key tar...
The dimorphic fungus Talaromyces marneffei: An opportunistic killer in Southeast Asia [0.03%]
两种形态的马尼菲青霉菌：东南亚机会性致病真菌杀手
Lottie Brown,Alex Andrianopoulos,Patrick C Y Woo et al.
Lottie Brown et al.
CK2 derived from brain microvascular endothelial cells induces astrocyte inflammatory response in Escherichia coli-induced meningitis [0.03%]
CK2来源于脑微血管内皮细胞在大肠杆菌诱导的脑膜炎中引起星形胶质细胞炎症反应
Dong Huo,Ruicheng Yang,Jiyang Fu et al.
Dong Huo et al.
Neuroinflammation within the central nervous system (CNS) is recognized as a critical pathological process in meningitic Escherichia coli (E. coli) infection, leading to severe neurodegenerative disorders and long-term sequelae. Astrocyte r...
Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex [0.03%]
锥体虫三联附着复合物线粒体外膜模块的组装
Philip Stettler,Salome Aeschlimann,Bernd Schimanski et al.
Philip Stettler et al.
The parasitic protozoan Trypanosoma brucei has a single mitochondrial nucleoid, anchored to the basal body of the flagellum via the tripartite attachment complex (TAC). The detergent-insoluble TAC is essential for mitochondrial genome segre...
The Salmonella phage shock protein system is required for defense against host antimicrobial peptides [0.03%]
沙门氏菌噬斑冲击蛋白系统对抵抗宿主抗菌肽防御起作用
Marie-Ange Massicotte,Aline A Fiebig,Andrei Bogza et al.
Marie-Ange Massicotte et al.
Macrophages are professional phagocytes that play a major role in engulfing and eliminating invading pathogens. Some intracellular pathogens, such as Salmonella enterica serovar Typhimurium, exploit macrophages as niches for their replicati...
Sec10 suppresses antiviral innate immune response by facilitating STUB1-mediated STAT1 degradation [0.03%]
Sec10通过促进STUB1介导的STAT1降解来抑制抗病毒先天性免疫反应
Fachao Sun,Wenqing Ma,Yanan Xu et al.
Fachao Sun et al.
The exocyst complex is a heterooctameric protein complex, the individual components of the complex are thought to act on specific biological processes. However, the role of Sec10, the central subunit of the complex, in host defense and vira...
Fexinidazole and corallopyronin a target Wolbachia-infected sheath cells present in filarial nematodes [0.03%]
菲辛尼达唑和石松吡咯烷A靶向丝虫线虫中的沃尔巴克体感染鞘细胞
Laura Chappell,Ricardo Peguero,William R Conner et al.
Laura Chappell et al.
The discovery of the endosymbiotic bacteria Wolbachia as an obligate symbiont of. filarial nematodes has led to antibiotic-based treatments for filarial diseases. While lab. and clinical studies have yielded promising results, recent animal...
Cytotoxic CX3CR1+ Vδ1 T cells clonally expand in an interplay of CMV, microbiota, and HIV-1 persistence in people on antiretroviral therapy [0.03%]
人类免疫缺陷病毒(HIV)-1感染的患者在接受抗逆转录病毒治疗时，巨细胞病毒和微生物群诱发携带CX3CR1+的Vδ1 T细胞克隆扩增导致细胞毒性增强
Nived Collercandy,Camille Vellas,Manon Nayrac et al.
Nived Collercandy et al.
Vδ1 γδ T cells are key players in innate and adaptive immunity, particularly at mucosal interfaces such as the gut. An increase in circulating Vδ1 cells has long been observed in people with HIV-1, but remains poorly understood. We perf...
N460S in PB2 and I163T in nucleoprotein synergistically enhance the viral replication and pathogenicity of influenza B virus [0.03%]
PB2 N460S和核蛋白I163T协同增强B型流感病毒复制能力和致病性
Yang Wang,Yu Gao,Tianxin Ma et al.
Yang Wang et al.
Influenza B viruses (IBVs), though often overshadowed by influenza A viruses (IAVs), remain a significant global public health concern, particularly during seasons when they predominate. However, the molecular mechanisms underlying IBV path...