The fungal STRIPAK complex: Cellular conductor orchestrating growth and pathogenicity [0.03%]
真菌STRIPAK复合体：调控生长和致病性的细胞指挥中心
Patricia P Peterson,Joseph Heitman
Patricia P Peterson
To Nguyen Thi Nguyen,Gareth Howells,Francesca L Short
To Nguyen Thi Nguyen
The bacterial pathogen Klebsiella pneumoniae is a serious public health threat due to its propensity to develop antimicrobial resistance (AMR), the emergence of hypervirulent strains able to cause community-acquired infections, and the more...
Coronavirus M protein impairs cilium during early infection by enhancing the AurA-HDAC6 axis [0.03%]
冠状病毒M蛋白通过增强AurA-HDAC6轴在病毒感染早期损害纤毛功能
Tenghan Zhuang,Peng Yang,Mengqin Wang et al.
Tenghan Zhuang et al.
Coronaviruses (CoVs) are implicated in human outbreaks and significant economic losses in the porcine and avian industries. Recent investigations have underscored the potential role of cilia within the respiratory tracts of infected hosts, ...
Fish TOLLIP manipulates ATG5 for autophagic degradation of STING to attenuate antiviral interferon responses [0.03%]
鱼TOLLIP通过自噬降解STING来调节抗病毒干扰素反应
Meng-Ze Tian,Yang-Yang Wang,Bao-Jie Cui et al.
Meng-Ze Tian et al.
While robust interferon (IFN) responses in fish are critical for viral clearance, dysregulated signalling can trigger detrimental hyperinflammation, necessitating precise immunoregulatory mechanisms. This study identified Toll-interacting p...
Rapid clearance of inducible HIV-1 proviruses after initiation of antiretroviral therapy [0.03%]
启动抗逆转录病毒治疗后诱导型HIV-1前病毒快速清除
Maria C Puertas,Lucía Bailón,Víctor Urrea et al.
Maria C Puertas et al.
Despite its efficacy, antiretroviral therapy (ART) is not curative, and HIV-1 rebound occurs whenever treatment is interrupted. The viral reservoir in latently infected cells is the source of the infection resurgence, making it crucial to u...
Rui Wang,Jingnan Lv,Liang Chen et al.
Rui Wang et al.
Antifungal persistence is the phenomenon that occurs when a subpopulation of fungal cells can survive in the presence of high concentrations of antifungal drugs, which is different from the concepts of antifungal resistance and tolerance. F...
Positive allosteric modulation of emodepside sensitive Brugia malayi SLO-1F and Onchocerca volvulus SLO-1A potassium channels by GoSlo-SR-5-69 [0.03%]
GoSlo-SR-5-69对马来分支丝虫SLO-1F和盘尾丝虫SLO-1A通道的正向别构调节作用
Mark McHugh,Charity N Njeshi,Nathaniel Smith et al.
Mark McHugh et al.
Human lymphatic filariasis and onchocerciasis are Neglected Tropical Diseases (NTDs), of major public health concern. Prophylaxis and treatment rely on anthelmintics that effectively eliminate migrating microfilariae but lack efficacy again...
HIV-1 Tat favors the multiplication of Mycobacterium tuberculosis and Toxoplasma by inhibiting clathrin-mediated endocytosis and autophagy [0.03%]
HIV-1 Tat通过抑制网格蛋白介导的胞吞作用和自噬促进结核分枝杆菌和弓形虫增殖
Aurélie Rivault,Audrey Bernut,Myriam Ben-Neji et al.
Aurélie Rivault et al.
HIV-1 and Mycobacterium tuberculosis (Mtb) coinfections are a major public health problem but are not well characterized. HIV-1 Tat is secreted by infected cells, generating nanomolar concentrations of Tat in the sera of people living with ...
Correction: Polyamine biosynthesis and eIF5A hypusination are modulated by the DNA tumor virus KSHV and promote KSHV viral infection [0.03%]
订正：DNA肿瘤病毒KSHV通过调节多胺生物合成和eIF5A的hypusine化促进KSHV病毒感染
Guillaume N Fiches,Zhenyu Wu,Dawei Zhou et al.
Guillaume N Fiches et al.
[This corrects the article DOI: 10.1371/journal.ppat.1010503.]. Copyright: © 2025 Fiches et al. This is an open access article distributed under the ter...
Published Erratum
PLoS pathogens. 2025 Sep 11;21(9):e1013496. DOI:10.1371/journal.ppat.1013496 2025
Unbiased and comprehensive identification of virus-derived circular RNAs in a large range of viral species and families [0.03%]
在大量病毒种类和家族中识别无偏见且全面的病毒源性环形RNA
Alexis S Chasseur,Maxime Bellefroid,Mathilde Galais et al.
Alexis S Chasseur et al.
Non-coding RNAs play a significant role in viral infection cycles, with recent attention focused on circular RNAs (circRNAs) originating from various viral families. Notably, these circRNAs have been associated with oncogenesis and alterati...