A single amino acid variant in the variable region I of AAV capsid confers liver detargeting [0.03%]
AAV衣壳可变区I中单个氨基酸变异赋予肝脏去靶效应
Ruxiao Xing,Mengyao Xu,Darcy Reil et al.
Ruxiao Xing et al.
AAV capsid serotypes isolated from nature have been widely used in gene delivery and gene therapy. Recently, more than 1,000 distinct AAV capsids were identified from human clinical samples by high-throughput, long-read DNA sequencing. In t...
A non-canonical activation of the host's ESCRT machinery is required for the scission of parasitophorous vacuoles and the replication of Leishmania donovani [0.03%]
宿主非经典ESCRT因子参与利什曼原虫细胞内寄生体的裂解及唐氏利什曼原虫的增殖
Javier Rosero,Peter E Kima
Javier Rosero
Leishmania donovani (Ld) is the causative agent of visceral leishmaniasis, which results in death if not treated. In mammalian cells, Ld live in vacuolar compartments called Leishmania parasitophorous vacuoles (LdLPVs) that enigmatically di...
Connecting basal body and mitochondrial DNA: TAC53 and the tubular organization of the tripartite attachment complex [0.03%]
连接基体和线粒体DNA：TAC53与三联体附着复合物的管状组织
Clirim Jetishi,Salome Aeschlimann,Bernd Schimanski et al.
Clirim Jetishi et al.
The Tripartite Attachment Complex (TAC) is essential for mitochondrial DNA (kDNA) segregation in Trypanosoma brucei, providing a physical link between the flagellar basal body and the mitochondrial genome. Although the TAC's hierarchical as...
Regulation of host immunity by a novel Legionella pneumophila E3 ubiquitin ligase [0.03%]
铜绿假单胞菌的E3连接酶调节宿主免疫反应机制研究
Shuxin Liu,Chunlin He,Yong Zhang et al.
Shuxin Liu et al.
Legionella pneumophila, the causative agent of Legionnaires' disease, exists ubiquitously in natural and artificial water systems. This pathogen poses serious threat to human health. One salient feature of L. pneumophila pathogenesis is the...
The interaction between GCN2 and eIF2 mediates the resistance of cotton bollworm to the Bacillus thuringiensis Cry1Ac toxin [0.03%]
GCN2与eIF2的互作介导棉铃虫对Bt毒蛋白Cry1Ac的抗性机制
Caihong Zhang,Jizhen Wei,Ningning Li et al.
Caihong Zhang et al.
Deciphering the molecular mechanisms underlying insect resistance to Cry toxins produced by the soil bacterium Bacillus thuringiensis (Bt) is crucial for the sustainable utilization of Bt-based products. Previously, we identified that the r...
Single-round infectious rotaviruses with deletions of VP7 or VP4 genes, based on SA11 and WC3 strain backbones, and their potential use as viral vectors [0.03%]
基于SA11和WC3菌株骨架的单轮感染性轮状病毒（VP7或VP4基因缺失）及其用作病毒载体的潜在应用
Tomohiro Kotaki,Yuta Kanai,Megumi Onishi et al.
Tomohiro Kotaki et al.
Single-round infectious rotavirus, which lacks a gene essential for virion assembly, serves not only as a safe and effective rotavirus vaccine but also as an orally-administrable viral vector vaccine that induces mucosal immunity. Previousl...
Proximity labelling reveals VPS13C as a regulator of Salmonella-containing vacuole fission [0.03%]
邻近标记揭示VPS13C是调节沙门氏菌含菌体出芽的调节因子
Anna K Waldmann,Dustin A Ammendolia,Andrew M Sydor et al.
Anna K Waldmann et al.
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a facultative intracellular bacterial pathogen that grows within a specialized membrane-bound compartment known as the Salmonella-containing vacuole (SCV). The molecular compositio...
Chimeric PRR T-cell-engager targeting cell surface β-1,3-glucan for invasive candidiasis [0.03%]
嵌合PRR T细胞衔接器靶向细胞表面β-1,3-葡聚糖用于侵袭性念珠菌病治疗
Yu Fang Sun,Shi Yu Guo,Si Qi Wang et al.
Yu Fang Sun et al.
Invasive candidiasis, primarily caused by Candida albicans, represents the most common fungal disease among hospitalized patients and poses a significant threat to human health. Intrinsic or acquired immunosuppression serves as a critical r...
A genome-wide analysis of YY1 and TFAP2 competition on overlapping motifs reveals their roles in HPV-induced carcinogenesis [0.03%]
针对染色体上重叠的YY1和TFAP2基序的竞争进行全基因分析以研究其在HPV致癌过程中的作用
Yi Liu,Shuang Ding,Haibin Liu
Yi Liu
The long non-coding RNA lnc-FANCI-2 acts as a host defense RNA and is highly expressed in HPV-positive cervical lesions. Its activation relies on the binding of the transcription factor YY1 to two conserved motifs in its promoter. We used D...
Differential tissue tropism and transmission efficiency of two dominant influenza D clades with overlapping but distinct receptor binding fine specificities in ferrets [0.03%]
两种优势流行流感D病毒谱系在雪貂中的受体结合特异性、组织嗜性和传播效率不同
Tirth Uprety,Chithra C Sreenivasan,Jieshi Yu et al.
Tirth Uprety et al.
Influenza D virus (IDV) utilizes bovines as a primary reservoir causing periodical spillover to pigs and other hosts. In this study, we utilized ferrets to study IDV with a focus on the role of the Hemagglutinin-Esterase-Fusion (HEF) protei...