Interprotomer crosstalk in mosaic viral glycoprotein trimers provides insight into polyvalent immunogen co-assembly [0.03%]
马赛克病毒糖蛋白三聚体内的互构象信号促进多价免疫原的共组装提供新视角
Chengbo Chen,Klaus N Lovendahl,Julie M Overbaugh et al.
Chengbo Chen et al.
SARS-CoV-2 variants have demonstrated the ability to evade immune responses, leading to waves of infection throughout the pandemic. In response, bivalent mRNA vaccines, encoding the original Wuhan-Hu-1 and emerging variants, were developed ...
The viral BCL2 protein BHRF1 of Epstein-Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication [0.03%]
爱泼斯坦-巴尔病毒的BCL2蛋白BHRF1通过促进AIM2炎性小体活化来促进裂解复制
Qingping Lan,Xiaolin Zhang,Yifan Sun et al.
Qingping Lan et al.
The absent in melanoma 2 (AIM2) protein recognizes viral and naked dsDNA and recruit apoptosis-associated speck-like protein containing CARD (ASC) to initiate inflammasome activation; however, the subversion of AIM2 activation by Epstein-Ba...
CEPR2 perceives group II CEPs to regulate cell surface receptor-mediated immunity in Arabidopsis [0.03%]
CEPR2通过感知芸苔素类油菜素来调控拟南芥细胞表面受体介导的免疫反应
Jakub Rzemieniewski,Patricia Zecua-Ramirez,Sebastian Schade et al.
Jakub Rzemieniewski et al.
Plant endogenous peptides are crucial for diverse aspects of plant physiology. Among them, C-TERMINALLY ENCODED PEPTIDEs (CEPs) have recently emerged as important regulators of plant growth and stress responses. CEPs are divided into two ma...
The antifungal mechanism of EntV-derived peptides is associated with a reduction in extracellular vesicle release [0.03%]
恩托维衍生肽的抗真菌机制与细胞外囊泡释放减少有关
Giuseppe Buda De Cesare,Melissa R Cruz,Shane A Cristy et al.
Giuseppe Buda De Cesare et al.
Candida albicans, an opportunistic fungal pathogen, causes systemic and superficial infections, especially in immunocompromised patients. Treatment of fungal infections is complicated by limited antifungal options and the development of dru...
Endoplasmic reticulum-anchored nonstructural proteins drive human astrovirus replication organelle formation [0.03%]
内质网锚定非结构蛋白驱动人astrovirus复制细胞器形成
Brooke Bengert,Samaneh Mehri,Madeline Holliday et al.
Brooke Bengert et al.
Human astroviruses (HAstV) are a major cause of acute, non-bacterial gastroenteritis and have been implicated in severe infections of the nervous system. Despite global prevalence, there are no established treatments for HAstVs due to a lac...
TisB enables antibiotic tolerance in Salmonella by preventing prophage induction through ATP depletion [0.03%]
TisB通过消耗ATP来预防前噬菌体诱导从而赋予沙门氏菌抗生素耐受性
Sebastian Braetz,Niclas Nordholt,Andreas Nerlich et al.
Sebastian Braetz et al.
Persisters are phenotypically antibiotic-tolerant cells which can survive antibiotic exposure without acquiring antibiotic resistance. A proposed important factor in persistence is low intracellular ATP levels, which are thought to reduce t...
The association of class II HLA alleles with tuberculosis-associated immune reconstitution inflammatory syndrome [0.03%]
结核病免疫重建炎性综合征与人类白细胞抗原-II类等位基因的相关性研究
Phuti Choshi,Sarah Pedretti,Tafadzwa Chimbetete et al.
Phuti Choshi et al.
Genetic associations within the human leukocyte antigen (HLA) gene complex and linked genes in TB-IRIS outcomes remains population specific and not well understood. Here, we conducted a study including well characterised HIV-TB coinfected p...
The F1148 hydrophobic lock: A critical determinant of SARS-CoV-2 spike protein-mediated membrane fusion via the 3H/CH cavity [0.03%]
SARS-CoV-2刺突蛋白通过3H/CH腔介导膜融合的关键决定因素F1148疏水锁
Fuzhi Lei,Yahan Lei,Zhenghong Yuan et al.
Fuzhi Lei et al.
The S2 subunit of the coronavirus Spike protein undergoes extensive conformational refolding to drive membrane fusion during viral entry. Although the HR1/HR2 six-helix bundle (6-HB) is recognized as the core mediator of fusion, the molecul...
Pathogen-induced damage in Drosophila: Uncoupling disease tolerance from resistance [0.03%]
果蝇病原诱导损伤：分离耐病性和抗性
Priscilla A Akyaw,Tânia F Paulo,Elvira Lafuente et al.
Priscilla A Akyaw et al.
Immune response against infections can be divided into mechanisms of resistance that ensure active pathogen elimination, and mechanisms of disease tolerance, which include processes that return the host to physiological homeostasis without ...
A PGRPLC1/Rel2-F axis controls Anopheles gambiae resistance to systemic infections with Gram-positive bacteria containing Lys-type peptidoglycan [0.03%]
含Lys型肽聚糖的革兰氏阳性菌引起的系统性感染激活按蚊体内PGRPLC1/Rel2信号轴以抵抗细菌感染
Amani Audi,Suheir Zeineddine,Sana Jaber et al.
Amani Audi et al.
In the Afrotropical malaria vector Anopheles gambiae s.l., the Imd pathway plays pleiotropic roles in immunity, including resistance to malaria parasites, that are mediated by its NF-κB transcription factor Rel2. Rel2 exists as a full-leng...