Fibrillarin-mediated 2'-O-methylation serves as a translation brake on uncapped enterovirus RNA [0.03%]
纤维蛋白体介导的2'-O-甲基化可作为未帽状肠病毒RNA翻译制动装置
Kui Zhang,Xuliu Zhou,Baocheng Yu et al.
Kui Zhang et al.
2'-O-methylation (Nm) is a key epitranscriptomic mark across diverse RNAs, yet its role in antiviral defense remains largely unexplored. To systematically investigate the landscape and functional significance of internal Nm modifications on...
An emergent biofilm program from inactivation of Candida albicans master regulators Efg1 and Ndt80 [0.03%]
白念珠菌调控因子Efg1和Ndt80失活后出现的生物膜程序
Eunsoo Do,Robert Zarnowski,David R Andes et al.
Eunsoo Do et al.
Biofilm formation by the fungus Candida albicans is a central virulence trait that enables colonization of implanted medical devices and mucosal surfaces. Biofilm formation reflects a complex regulatory network, and depends upon multiple ma...
Structural and evolutionary insights into DAF-12 interactions with transcriptional coactivators in parasitic nematodes [0.03%]
线虫寄生线虫DAF-12与转录共激活剂相互作用的结构和进化见解
Manon Mallet,Yéléna Martin,João E Carvalho et al.
Manon Mallet et al.
Parasitic nematodes infect billions of humans and livestock worldwide, causing major health and economic burdens, while the spread of anthelmintic resistance threatens current control strategies. A critical step in parasite infection is the...
m6A RNA methylation modulates IFN-γ-stimulated intestinal epithelial cell-intrinsic antiparasitic defense [0.03%]
m6A RNA甲基化调节IFN-γ刺激的肠上皮细胞内在抗寄生虫防御功能
Chansorena Pok,Ai-Yu Gong,Marion L Graham et al.
Chansorena Pok et al.
N6-methyladenosine (m6A) RNA methylation is one of the most prevalent reversible post-transcriptional RNA modifications and has been recognized as a crucial regulator of host immune responses. Intestinal epithelial cells (IECs) constitute a...
Retraction: Genome-wide characterization of Src Homology-3 (SH3) domain-containing proteins in the development and pathogenicity of Fusarium graminearum [0.03%]
撤稿：镰刀菌Src同源区3（SH3）结构域基因组广泛特征及其在发育和致病性中的作用
PLOS Pathogens Editors
PLOS Pathogens Editors
Auxin biosynthesis and signaling drive virulence and plant adaptation in Dickeya dadantii [0.03%]
植物病原菌Dickeya dadantii中的生长素生物合成和信号转导决定了其致病性和植物适配性
Amalia Roca,Saray Santamaría-Hernando,Zulema Udaondo et al.
Amalia Roca et al.
Plants and their associated bacteria engage in complex bidirectional interactions mediated by a diverse array of signaling molecules of both plant and microbial origin. Indole-3-acetic acid (IAA) is a central phytohormone regulating plant g...
Callitrichine herpesvirus 3 in the common marmoset is a model of Epstein-Barr virus infection and associated lymphoma [0.03%]
作为一种淋巴瘤相关病毒，食蟹猴叫猿疱疹病毒3是埃博拉病毒的模型
Stacey L Piotrowski,Xiaofan Li,Caitlin E Fitzpatrick et al.
Stacey L Piotrowski et al.
Herpesviruses, such as Epstein-Barr virus (EBV), are thought to potentially play a significant role in multiple disease processes, including neoplasia, multiple sclerosis (MS), and more recently, Alzheimer's disease (AD). Animal models rema...
Complement evasion by apicomplexans: Convergent strategies across diverse parasites [0.03%]
逐突器寄生虫的补体逃逸机制：不同寄生虫之间的趋同进化策略
Sofía Espinosa-Hernández,Carlos J Ramírez-Flores
Sofía Espinosa-Hernández
Apicomplexan parasites encounter the complement system during extracellular stages of infection, where it imposes a major barrier to survival. Complement activation promotes pathogen elimination through opsonization, inflammation, and membr...
The vesicular stomatitis virus matrix protein promotes FACT subunit depletion to suppress the FEAR pathway [0.03%]
囊泡口炎病毒基质蛋白通过促进染色质重塑复合物FACT的降解来抑制FEAR通路
Emily A Rex,Dahee Seo,Aaron Embry et al.
Emily A Rex et al.
We recently identified the FACT-ETS-1 Antiviral Response (FEAR) pathway as an interferon-independent innate immune response that restricts DNA virus replication and that is antagonized by poxvirus-encoded A51R proteins (Rex et al., 2024, Na...
The durable resistance gene Tm-22 remains partially resistant to tomato brown rugose fruit virus [0.03%]
持久抗病基因Tm-22对番茄褐果病毒仍保持部分抗性
Shaokang Zhang,Mark A Bernards,Aiming Wang
Shaokang Zhang
The tomato Tm-22 gene is a highly effective, and durable resistance gene in agriculture that has protected tomato production against viruses of the Tobamovirus genus, such as tomato mosaic virus (ToMV) and tobacco mosaic virus (TMV) for ove...