A highly potent and broadly accessible bispecific nanobody for the treatment of ebola virus infections [0.03%]
一种针对埃博拉病毒感染的高效且广泛适用的双特异性纳米抗体疗法
Fan Bu,Gang Ye,Kimberly Morsheimer et al.
Fan Bu et al.
Ebola virus (EBOV) causes recurring outbreaks, with a case fatality rate of about 40%. Currently approved vaccine and antibody therapies face major limitations, including only modest reductions in mortality and restricted accessibility due ...
HCMV encoded UL84 hijacks FHL2 to suppress type I interferon production and enhance viral replication [0.03%]
人巨细胞病毒编码的UL84劫持FHL2以抑制I型干扰素产生并增强病毒复制
Ruilin Li,Sisi Xia,Xin Li et al.
Ruilin Li et al.
Virus infection activates the host's innate immune responses, which is a very precise and complex biological process and will lead to the immediate transcription of type I interferon. The general transcriptional activator proteins such as I...
De novo nucleotide biosynthesis and its dynamic regulation are crucial for systemic infection by extraintestinal Escherichia coli [0.03%]
从头合成核苷酸及其动态调节是肠外大肠杆菌系统性感染的关键因素
Chu Zhang,Yi Yang,Shuang Wang et al.
Chu Zhang et al.
Extraintestinal Escherichia coli (ExPEC) proliferates rapidly in the bloodstream, causing life-threatening systemic infections with high mortality rates. Understanding how ExPEC adapts to the blood environment is essential for elucidating i...
The βC1 protein encoded in betasatellites promotes begomovirus-whitefly coexistence by subverting vector infestation-induced plant antiviral defenses [0.03%]
β卫星病毒编码的βC1蛋白通过逆转寄主植物对病毒的抗病响应促进基因组病毒与媒介昆虫共生关系的建立
Shi-Xing Zhao,Yi-Ming Liu,Su-Dan Wang et al.
Shi-Xing Zhao et al.
The transmission of many plant viruses depends on arthropod vectors, which acquire viruses while feeding on infected plants and subsequently inoculate un-infected hosts. Efficient virus acquisition, particularly for persistently transmitted...
Epstein-barr virus latent membrane protein 1 targets cIAP1, cIAP2 and TRAF2 for proteasomal degradation to activate the non-canonical NF-κB pathway [0.03%]
EB病毒潜伏膜蛋白1通过泛素-蛋白酶体系统降解cIAP1、cIAP2和TRAF2以活化非经典NF-κB信号通路
Yizhe Sun,Shunji Li,Bidisha Mitra et al.
Yizhe Sun et al.
The Epstein-Barr virus (EBV) oncoprotein Latent Membrane Protein 1 (LMP1) is expressed in multiple malignancies and is critical for B-cell immortalization. LMP1 constitutively activates NF-κB signaling pathways, which are essential for EBV...
Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase [0.03%]
抗正痘病毒药物通过靶向病毒DNA聚合酶抑制牛结节性皮肤病病毒感染复制
Zuxin Gong,Jiaqi Dai,Hailong Qu et al.
Zuxin Gong et al.
Lumpy skin disease (LSD) is an emerging transboundary disease caused by lumpy skin disease virus (LSDV), posing significant threats to global cattle health in the absence of validated drugs. Here, we constructed a recombinant LSDV (rLSDV) e...
Molecular mechanism of ziresovir targeting the fusion glycoprotein of respiratory syncytial virus [0.03%]
扎里索维尔回避呼吸道合胞病毒融合糖蛋白的分子机制研究
Mengrong Yan,Jingjing Zou,Zhao Gao et al.
Mengrong Yan et al.
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants and the elderly worldwide. Although prophylactic monoclonal antibodies and RSV vaccines are available for preventing severe RSV infection,...
Oo-No: Ophidiomyces ophidiicola-bacterial interactions and the role of skin lipids in development of ophidiomycosis [0.03%]
蛇皮脂质在蛇皮肤丝状真菌病发病中的作用及蛇丝状真菌(Ophidiomyces ophidiicola)与细菌的相互作用
Jason W Dallas,Mitra Ghotbi,Alexander J Rurik et al.
Jason W Dallas et al.
Diversify and conquer: How effector diversity is shaped by host-microbe co-evolution [0.03%]
化多样，征服世界：效应子多样性是如何受到宿主-微生物共同进化的塑造的？
Marion C Müller,Sabine Brumm,Yiheng Hu et al.
Marion C Müller et al.
Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection [0.03%]
禽源H5N1流感病毒的神经氨酸酶在基因水平上发生变异可降低其唾液酸苷酶活性，以补偿血凝素结合能力较弱并有利于感染人类
Yohei Watanabe,Madiha S Ibrahim,Yasuha Arai et al.
Yohei Watanabe et al.
Clade 2.2 H5N1 influenza viruses have caused an unusually high number of human infections, providing a unique opportunity to investigate early molecular steps associated with host adaptation. Although most work has focused on hemagglutinin ...