Variation in natural infection outcomes and cancer cell release from soft-shell clams (Mya arenaria) with bivalve transmissible neoplasia [0.03%]
软壳 clam（Mya arenaria）中自然感染结果和肿瘤细胞释放的差异以及双壳动物传染性肿瘤的影响
Rachael M Giersch,Jordana K Sevigny,Sydney A Weinandt et al.
Rachael M Giersch et al.
Bivalve transmissible neoplasias (BTNs) are leukemia-like cancers found in at least 10 bivalve species, in which the cancer cells themselves transfer from one individual to another, spreading as an unusual form of infectious disease. Before...
Acinetobacter phages use distinct strategies to breach the capsule barrier [0.03%]
不动杆菌噬菌体采用不同的策略突破荚膜屏障
Alexis J McCalla,Forrest C Walker,Fabiana Bisaro et al.
Alexis J McCalla et al.
Acinetobacter baumannii is an opportunistic pathogen that is a growing threat in hospital settings due to its alarmingly high rates of antibiotic resistance. Alternative therapies are urgently needed to manage the growing burden of untreata...
Defined roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages [0.03%]
金黄色葡萄球菌POT转运蛋白DtpT在人类巨噬细胞中对二肽/三肽摄取和谷胱甘肽利用中的作用定义
Imran Khan,Sandy J MacDonald,Sigurbjörn Markusson et al.
Imran Khan et al.
Peptides available in biological niches inhabited by the human pathogen Staphylococcus aureus serve as a rich source of amino acids required for growth and successful host colonisation. Uptake of peptides by S. aureus involves at least two ...
Liver biopsies obtained throughout SIV infection reveal evolving interferon stimulated protein expression within distinct monocyte/macrophage subsets [0.03%]
猴免疫缺陷病毒(SIV)感染全程获取的肝脏活检样本揭示了不同单核细胞/巨噬细胞亚群中干扰素刺激蛋白表达的动态变化规律
Nina Derby,Brooke I Johnson,Sreya Biswas et al.
Nina Derby et al.
Liver dysfunction is more common and more severe among people with HIV than in the general population. Our previous transcriptomic analysis identified an increased hepatic type-1 interferon (IFN-1) response in simian immunodeficiency virus ...
In vivo and in vitro recombinant systems of a novel variant demonstrate cross-reactive neutralization for the HCV model virus, Norway rat hepacivirus [0.03%]
体内和体外重组系统证实新型HCV病毒变种可产生交叉中和作用：挪威实验鼠肝炎病毒感染模型示范研究
Caroline E Thorselius,Andreas Kok,Ulrik Fahnøe et al.
Caroline E Thorselius et al.
The lack of immunocompetent animal models severely impedes the development of vaccines against hepatitis C virus (HCV) and researchers have therefore explored the application of surrogate virus models. Norway rat hepacivirus 1 (NrHV) is a p...
STK-mediated FadR phosphorylation regulates the acid resistance and virulence of Streptococcus suis [0.03%]
STK介导的FadR磷酸化调节猪链球菌的酸耐受性和致病性
Sen Li,Zhe Ma,Huixing Lin et al.
Sen Li et al.
The phagolysosomes of macrophages play a crucial role in eradicating pathogenic microorganisms, but bacteria have evolved sophisticated mechanisms to survive in the acidic environment of phagolysosomes, leading to host infection and subsequ...
T6SS4 is heterogeneously expressed in Yersinia pseudotuberculosis and is a target for transcriptional and post-transcriptional regulation [0.03%]
耶尔森菌假结核棒杆菌中的T6SS4异质表达并受转录和转录后调控影响
Anna Kerwien,Britta Körner,Ines Meyer et al.
Anna Kerwien et al.
The type VI secretion system (T6SS) is a complex secretion system encoded by many Gram-negative bacteria to translocate effector proteins directly into target cells. Due to its high complexity and energy-intensive firing process, regulation...
The devil in more detail: Eco-evolutionary genomics of Tasmanian devil persistence despite range-wide spread of a fatal, transmissible cancer [0.03%]
更详细的魔鬼：塔斯马尼亚魔鬼的生态进化基因组学，尽管整个范围内的致命传播性癌症广泛传播
Andrew Storfer,Marc A Beer,Dylan Gallinson et al.
Andrew Storfer et al.
Monitoring intracellular replication dynamics unveils high proportion of non-replicating antibiotic-tolerant Staphylococcus aureus inside osteoblasts [0.03%]
细胞内复制动力学监测揭示了骨细胞内高比例的非增殖性耐药表皮葡萄球菌
Florian C Marro,Jacques Brocard,Allison Faure et al.
Florian C Marro et al.
Therapeutic failures and relapses are critical challenges in Staphylococcus aureus bone and joint infections. These issues may stem, in part, from the incomplete eradication of S. aureus residing within osteoblasts, the bone-forming cells, ...
The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistent replication in cell culture [0.03%]
HEV菌株通过Orf2蛋白拮抗细胞天然免疫反应实现体外持久复制
Ann-Kathrin Mehnert,Sebastian Stegmaier,Carlos Ramirez Alvarez et al.
Ann-Kathrin Mehnert et al.
Hepatitis E virus (HEV) is a significant human pathogen causing both acute and chronic infections worldwide. The cell-intrinsic antiviral response serves as the initial defense against viruses and has been shown to be activated upon HEV inf...