Host hybridization enabled the emergence of a reassorted hantavirus lineage [0.03%]
宿主杂交开启了重组汉坦病毒谱系的起源事件
Anton Labutin,Nadine Ritter,Guiscard Seebohm et al.
Anton Labutin et al.
The exchange of genetic material between individuals is a key driver of evolution and diversification across most branches of life. Segmented viruses can exchange genetic material through reassortment of genomic segments. New viral strains ...
Noncanonical bactericidal activity of teleost type I interferon is conferred by a membrane-targeting C-terminal peptide [0.03%]
非典模式的细菌杀菌活性由膜定位C端肽赋予虹彩病毒I型干扰素所致
Han Zhang,Ying Wu,Xiaoyuan Zheng et al.
Han Zhang et al.
Type I interferons (IFNs) are indispensable antiviral cytokines in nonspecific immunity, yet they play dual roles in bacterial infections in mammals. Recent studies have revealed a subset of strongly cationic type I IFNs possessing potent a...
A novel stress response pathway mediates biofilm architecture in Pseudomonas aeruginosa [0.03%]
铜绿假单胞菌中的一种新型压力反应通路可调节生物膜的结构
Ainelen Piazza,Catriona M A Thompson,Govind Chandra et al.
Ainelen Piazza et al.
Pseudomonas aeruginosa is a multidrug-resistant opportunistic pathogen, with chronic infections often associated with biofilm formation. Here, we investigate the previously uncharacterized gene PA3049, which is upregulated under biofilm con...
Non-human primate LIBRA-Seq accelerates neutralizing antibody discovery in RM vaccinated against HIV-1 [0.03%]
非人灵长类LIBRA-Seq加速了HIV-1疫苗接种_RM中中和抗体的发现
Christopher T Edwards,Aaron D Silva-Trenkle,Anusmita Sahoo et al.
Christopher T Edwards et al.
Broadly neutralizing antibodies (bNAbs) exhibit protective efficacy against HIV-1 infection making them an ideal archetype for HIV-1 vaccine design. Presently, no vaccine candidate has induced antibody responses capable of meaningful protec...
VRK3 promotes KSHV infection by suppressing the antiviral type I interferon response [0.03%]
VRK3通过抑制I型干扰素抗病毒反应促进卡波氏肉瘤疱疹病毒感染
Caroline J Yu,Blossom Damania
Caroline J Yu
Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic gammaherpesvirus that is associated with several human malignancies, and primary infection by KSHV can activate both DNA and RNA sensing pathways. Host innate immunity is a rapid,...
A broad-spectrum phage-encoded mechanism to disarm bacterial type IV filaments [0.03%]
一种广谱的噬菌体编码机制可使细菌第四型菌毛失活
Nathan A Roberge,Paankhi Dave,Véronique Taylor et al.
Nathan A Roberge et al.
Bacteria-specific viruses, or phages, can modify host cell physiology to thwart competitors. The Pseudomonas aeruginosa-specific phage DMS3 encodes Aqs1, a protein inhibitor of type IV pilus (T4P) function. T4P are important virulence facto...
The axonal transport velocity of prions is independent of prion formation [0.03%]
朊病毒的轴突运输速度与朊病毒形成无关
Sam M Koshy,Jay Hrdlicka,Michael G Nichols et al.
Sam M Koshy et al.
Prion diseases are caused by PrPSc, the self-templating infectious conformation of the normal host-encoded prion protein, PrPC. Spread of PrPSc in the peripheral and central nervous system follows a highly predictable pattern consistent wit...
Selection profiles in RNA viruses reflect the characteristics of viruses more than individual proteins [0.03%]
RNA病毒的选择谱系反映了病毒本身的特点而不是单独的蛋白质特点
Laura Muñoz-Baena,Hugo G Castelán-Sánchez,Sareh Bagherichimeh et al.
Laura Muñoz-Baena et al.
Proteins that are exposed on the surface of a virus are frequently subject to strong selection to escape from neutralizing antibodies. To investigate whether surface-exposed (SE) and non-exposed (NE) proteins encoded by RNA viruses exhibit ...
Phosphatidylinositol-4-phosphate signaling regulates dense granule biogenesis and maturation in Toxoplasma gondii [0.03%]
异磷酸磷脂酰肌醇信号转导调节刚地弓形虫致密颗粒的生成和成熟
Angela Arabiotorre,Megan Formanowicz,Vytas A Bankaitis et al.
Angela Arabiotorre et al.
Phosphoinositide metabolism defines the foundation of a major signaling pathway that is conserved throughout the eukaryotic kingdom. Although the 4-OH phosphorylated phosphoinositides phosphatidylinositol-4-phosphate (PtdIns4P) and phosphat...
IRES-like element-mediated translation of vsp1S4(-) suppresses BmCPV replication via RNAi antagonism [0.03%]
IRES-like元件介导的vsp1S4(-)翻译通过RNAi阻抗抑制杆中双DNA病毒复制
Xialing Chen,Qian Teng,Haoni Xue et al.
Xialing Chen et al.
Double-stranded RNA (dsRNA) viruses are thought to express proteins exclusively from their sense strand, while the antisense strand serves primarily as a replication template. Whether the antisense strand harbors hidden coding potential rem...