Marie-Dominique Jolivet,Hua Wei,Isabella Gantner et al.
Marie-Dominique Jolivet et al.
The impact of clade B lineage 5 MERS coronaviruses spike mutations from 2015 to 2023 on virus entry and replication competence [0.03%]
2015年至2023年克拉德B谱系5中东呼吸综合征冠状病毒刺突蛋白突变对病毒进入和复制能力的影响
Ray T Y So,Kenrie P Y Hui,John C W Ho et al.
Ray T Y So et al.
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging coronavirus that can cause zoonotic disease in humans with lethal severe viral pneumonia. Dromedary camels are the source of zoonotic infection. As of November 2025, MER...
Inhibitory NK receptor expression associates with altered antimalarial function of γδ T cells [0.03%]
抑制性NK受体的表达与γδT细胞抗疟功能改变有关
Meagan E Olive,Perri C Callaway,Mikias Ilala et al.
Meagan E Olive et al.
Gamma delta (γδ) T cells are important mediators of the immune response to childhood malaria. Human Vγ9+Vδ2+ T cells possess intrinsic, HLA-independent responsiveness to Plasmodium falciparum phosphoantigens produced in the blood stage ...
Chlamydial membrane vesicles deliver the beta barrel outer membrane protein OmpA to mitochondria to inhibit apoptosis [0.03%]
沙眼衣原体膜囊泡可向线粒体递送β barrels型外膜蛋白OmpA以抑制细胞凋亡
Andreea Mesesan,Henry Oehler,Collins Waguia Kontchou et al.
Andreea Mesesan et al.
Chlamydiae are obligate intracellular bacteria that inhibit mitochondrial apoptosis to maintain integrity of the host cell. We have previously reported that a chlamydial outer membrane β-barrel protein, OmpA, can during ectopic expression ...
Mechanistic insights and in vivo HIV suppression by the BRD4-targeting small molecule ZL0580 [0.03%]
靶向BRD4的小分子ZL0580的机制研究及其体内抑制HIV的作用
Naveen Kumar,Zonghui Ma,Fuquan Long et al.
Naveen Kumar et al.
Epigenetic suppression and durable silencing of HIV represent a promising strategy to achieve ART-free remission, consistent with the "block and lock" HIV cure paradigm. BRD4 is a host epigenetic reader and plays a critical role in HIV tran...
Genome-wide CRISPR screening identifies Annexin A1 as a facilitator of porcine astrovirus entry [0.03%]
全基因组CRISPR筛选鉴定出Annexin A1是猪Astrovirus进入的促进因子
Yuhang Luo,Qingting Dong,Shiqin Yi et al.
Yuhang Luo et al.
Porcine astrovirus (PAstV) is an important and widespread pathogen in swine, linked to diarrheal outbreaks and extraintestinal disease. How PAstV enters host cells has remained unclear, and no cellular factor has been defined for PAstV entr...
Correction: Toggle switch residues control allosteric transitions in bacterial adhesins by participating in a concerted repacking of the protein core [0.03%]
纠正：开关残基通过参与蛋白质核心的协同重包装来控制细菌粘附素中的别构转换
Dagmara I Kisiela,Pearl Magala,Gianluca Interlandi et al.
Dagmara I Kisiela et al.
[This corrects the article DOI: 10.1371/journal.ppat.1009440.]. Copyright: © 2026 Kisiela et al. This is an open access article distributed under the te...
Published Erratum
PLoS pathogens. 2026 Feb 2;22(2):e1013925. DOI:10.1371/journal.ppat.1013925 2026
Correction: A Helicobacter pylori flagellar motor accessory is needed to maintain the barrier function of the outer membrane during flagellar rotation [0.03%]
订正：一种幽门螺杆菌鞭毛马达辅助蛋白在鞭毛旋转期间维持外膜屏障功能所需
Kyle Rosinke,Shoichi Tachiyama,Jan Mrázek et al.
Kyle Rosinke et al.
[This corrects the article DOI: 10.1371/journal.ppat.1012860.]. Copyright: © 2026 Rosinke et al. This is an open access article distributed under the te...
Published Erratum
PLoS pathogens. 2026 Feb 2;22(2):e1013912. DOI:10.1371/journal.ppat.1013912 2026
HIV impairs and exploits pulmonary Th17 and Th22 cell-mediated immune responses to Mycobacterium tuberculosis [0.03%]
人类免疫缺陷病毒损害并利用肺部Th17和Th22细胞介导的对结核杆菌的免疫反应
Yazmin B Martinez-Martinez,Matthew B Huante,Kubra F Naqvi et al.
Yazmin B Martinez-Martinez et al.
Tuberculosis (TB) kills an estimated 1.25 million people annually and is the leading cause of death in people with HIV (PWH) (1). The CD4+ T helper (Th) populations play significant roles in protective immunity to Mycobacterium tuberculosis...
Prevalence and mechanisms of high-level carbapenem antibiotic tolerance in clinical isolates of Klebsiella pneumoniae [0.03%]
肺炎克雷伯菌临床分离株中碳青霉烯类抗生素高耐药的流行及机制研究
Trevor Cross,Facundo Torres,Nadia Nikulin et al.
Trevor Cross et al.
Antibiotic tolerance is the ability of bacteria to survive normally lethal doses of antibiotics for extended time periods. Clinically significant Enterobacterales, for example, can exhibit high tolerance to the last-resort antibiotic merope...