ddOTs: A multiplexed quantitative ddPCR approach for resolving overlapping hepatitis B virus transcripts to decipher cccDNA-driven transcription [0.03%]
用于解析cccDNA驱动转录的多重定量(dd)PCR方法以解析重叠的乙型肝炎病毒转录本
Nazim Sarica,Oceane Lopez,João Diogo Dias et al.
Nazim Sarica et al.
Chronic hepatitis B virus infection persists as a global health crisis, driving life-threatening liver pathologies such as hepatocellular carcinoma. Central to HBV's resilience is the covalently closed circular DNA (cccDNA), a viral minichr...
Post-COVID impairment of T cell responses to community-acquired pathogens can be modified by activating cellular metabolism [0.03%]
激活细胞代谢可调节COVID后社区获得性病原体的T细胞反应受损状况
Daniel D Carroll,Kamacay Cira,Jack Archer et al.
Daniel D Carroll et al.
Infection rates involving bacterial and viral pathogens have increased precipitously after the COVID-19 pandemic, though underlying causes remain elusive. Potential causes ranging from increased hospitalizations during the pandemic or great...
Mind the gap between RNA and protein levels: A general phenomenon with implications for virology [0.03%]
注意RNA和蛋白质水平之间的差异：一个普遍现象及其对病毒学的意义
Luca D Bertzbach,Timon Kapischke,Lars Kaderali et al.
Luca D Bertzbach et al.
An orally available PfPKG inhibitor blocks Plasmodium's infection of the liver [0.03%]
一种口服的PfPKG抑制剂可阻断疟原虫感染肝脏
Hanna Dhiyebi,Aminata Mbaye,Anusha Thaniana et al.
Hanna Dhiyebi et al.
Malaria remains a global health threat exacerbated by emerging resistance to antimalarial therapies and insecticides, climate-driven outbreaks, and limited chemoprotective options. Here, we report the characterization of RUPB-61, the first ...
FIKK1, a member of the FIKK kinase family, phosphorylates VAR2CSA and regulates adhesion of Plasmodium falciparum-infected erythrocytes to the placental receptor CSA [0.03%]
FIKK1是FIKK激酶家族的一员，通过磷酸化VAR2CSA调节恶性疟原虫在胎盘中粘附于CSA受体的过程
Benoît Gamain,Jean-Philippe Semblat,Heledd Eavis et al.
Benoît Gamain et al.
Plasmodium falciparum promotes the adhesion of infected erythrocytes (IEs) to host cells by extensively remodeling their surface. For this process, the parasite exports a large number of proteins to its host erythrocyte, including members o...
Deep phenotypic profiling uncovers cryptic effects of antifilarial drugs [0.03%]
深度表型分析揭示了抗丝虫药物的潜在药效
Kaetlyn T Ryan,Nathalie Dinguirard,Clair R Henthorn et al.
Kaetlyn T Ryan et al.
The anthelmintics ivermectin, albendazole, and diethylcarbamazine are the backbone of mass drug administration (MDA) campaigns targeting human filariasis, yet their direct effects on parasites are still not fully defined or understood. The ...
Bacillus thuringiensis pathogenicity islands encode regulatory circuits controlling insecticidal Cry toxin expression during vegetative growth [0.03%]
芽孢杆菌伴孢晶体素杀虫毒蛋白的表达调控机制研究取得进展
Bowen Zhang,Zhiyu Liu,Hang Zhang et al.
Bowen Zhang et al.
Bacillus thuringiensis (Bt) produces insecticidal toxins, including Cry and Vip3 proteins, that are widely used for biological pest control. Cry proteins are classically expressed during sporulation under the control of sporulation-specific...
The brain as an HIV reservoir: Recent findings using autopsy tissues from people with HIV [0.03%]
HIV潜伏库的脑部研究：利用人类尸检组织的最新发现
Rajnish S Dave,Ayo A Oludipe,Elizabeth C Pasipanodya et al.
Rajnish S Dave et al.
HIV persistence within anatomical reservoirs remains the primary barrier to achieving an HIV cure. While antiretroviral therapy effectively suppresses plasma viremia, it does not eliminate integrated proviral genomes that persist in long-li...
Biofilm formation during pneumococcal carriage imprints naturally acquired humoral immunity [0.03%]
肺炎链球菌定植期间的生物被膜形成印制了自然获得的体液免疫反应
Jessica R Lane,Henry Mauser,Silvia E Santana-Krimskaya et al.
Jessica R Lane et al.
Streptococcus pneumoniae (Spn) colonization of the nasopharynx is a prerequisite for transmission and invasive disease. To investigate how repeated asymptomatic colonization shapes immunity and influences bacterial traits, we developed the ...
A TCER-1-siRNA regulatory axis suppresses antibacterial innate immunity in C. elegans [0.03%]
TCER-1-siRNA调控轴通过抑制C.elegans的抗菌先天免疫响应来激活肠道病原体感染
Nikki Naim,Francis R G Amrit,Mayur N Devare et al.
Nikki Naim et al.
Small interfering RNAs (siRNAs) are important regulators of gene expression with well-established roles in pathogen defense. Yet, their specific roles in antibacterial immunity are not well understood. Here, we identify an siRNA pathway inv...