Impaired host shutoff is a fitness cost associated with baloxavir marboxil resistance mutations in influenza A virus PA/PA-X nuclease domain [0.03%]
PA/PA-X 核酸内切酶结构域中巴洛沙韦抗性突变与宿主转录关闭受损相关的适应性代价
Jack R Case,Denys A Khaperskyy
Jack R Case
The polymerase acidic (PA) protein is a subunit of the trimeric influenza A virus (IAV) RNA-dependent RNA polymerase and the target of the anti-influenza drug baloxavir marboxil (BXM). As with other direct-acting antivirals, treatment with ...
Mitochondrial ribosomes in apicomplexan and trypanosomatid parasites: Dissimilar drivers of complexity and convergent features [0.03%]
球内症原虫和沙眼衣原体寄生虫的线粒体核糖体：不同的复杂性驱动因素及趋同特征
Ondřej Gahura,Prashant Chauhan
Ondřej Gahura
M Willow H Maxwell,Alex Papp,Bharat Rohilla et al.
M Willow H Maxwell et al.
Plant-parasitic nematodes secrete molecules to manipulate their hosts, but little is known about their mode of delivery and packaging. Here, we describe microRNA-containing exosomes that are secreted by root-knot nematodes and systemically ...
Correction: Correction: STAT3, MYC, and EBNA1 cooperate through a ZC3H18 transcriptional network to regulate survival and proliferation of EBV-positive lymphomas [0.03%]
关于：STAT3、MYC和EBNA1通过ZC3H18转录网络协同调节EB病毒阳性淋巴瘤的存活和增殖的更正
PLOS Pathogens Staff
PLOS Pathogens Staff
[This corrects the article DOI: 10.1371/journal.ppat.1013754.]. Copyright: © 2026 The PLOS Pathogens Staff. This is an open access article distributed u...
Published Erratum
PLoS pathogens. 2026 Feb 9;22(2):e1013931. DOI:10.1371/journal.ppat.1013931 2026
B Cell Receptor's function in virus entry: Anti-SARS-CoV-2 B cell receptors can mediate viral entry in an ACE2-independent mechanism [0.03%]
BCR在病毒进入中的作用：抗SARS-CoV-2的B细胞受体可以通过不依赖ACE2的方式介导病毒进入
Rene Larios,Md Belal Hossain,Rebecca Brown et al.
Rene Larios et al.
B cells play a crucial role in humoral immunity, acting as sentinels against viral infections by using their B cell receptors (BCRs) to recognize viral proteins. This recognition typically triggers a response leading to the production of ne...
Porcine B cell receptor repertoire uncovers balanced recognition of antigenic structures on serotype Asia1 foot-and-mouth disease virus [0.03%]
猪B细胞受体库平衡识别亚洲I型口蹄疫病毒抗原结构
Shulun Huang,Shanquan Wu,Fengjuan Li et al.
Shulun Huang et al.
Of the seven serotypes of foot-and-mouth disease virus (FMDV) strains circulating globally, serotype Asia1 has been effectively eradicated in China through systematic vaccination in livestock. The structural characteristics of serotype Asia...
Antigen flexibility supports the avidity of hemagglutinin-specific antibodies at low antigen densities [0.03%]
抗原变异性支持血凝素特异性抗体在低抗原密度下的亲和力
Ananya Benegal,Yuanyuan He,Katilyn Ho et al.
Ananya Benegal et al.
The receptor-binding protein of influenza A virus, hemagglutinin (HA), is the most abundant protein on the viral surface. While high densities of HA are thought to improve cellular attachment by increasing avidity for the viral receptor, th...
A novel SO2 probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylation [0.03%]
一种新型SO₂探针通过促进LAMP1半胱氨酸375位点的亚硫酸化抑制Senecavirus A感染诱导的lysophagy
Shuo Wang,WenWen Han,BaoXiang Zhao et al.
Shuo Wang et al.
Lysophagy plays a key role in maintaining autophagy homeostasis, but the induction and regulation mechanisms of lysophagy are not clear. In this study, we found that Senecavirus A (SVA) dramatically decreased lysosomal-associated membrane p...
Isolation and characterization of broadly-neutralizing anti-HCMV-gB antibodies from human donors using a prefusion-stabilized HCMV gB variant [0.03%]
人供体中广谱抗HCMV-gB抗体的分离与表征使用预融合稳定的HCMV gB变异体
Maria K McClave,Yu-Hsin Wan,Ellen M White et al.
Maria K McClave et al.
Human cytomegalovirus (HCMV) poses a significant risk to immunocompromised individuals and is the leading cause of congenital birth defects worldwide. There is no cure or robust treatment options, although neutralizing antibodies (nAbs) der...
Shaping immunity: Genetic diversity as a key resource for crop protection [0.03%]
塑造免疫力：遗传多样性是作物保护的关键资源
Amit Fenn,Samara Mireza Correia de Lemos,Thomas Lahaye et al.
Amit Fenn et al.