A bacterial-type cardiolipin synthase in Plasmodium spp. supports mitochondrial respiration and is important for liver stage maturation [0.03%]
疟原虫中的细菌型卡迪奥赖素合酶支持线粒体呼吸作用并在肝阶段发育中起重要作用
Karavadra Asha Adhur,Nirdosh Nirdosh,Aakash Chandramouli et al.
Karavadra Asha Adhur et al.
The mitochondrion of malaria-causing Plasmodium spp. supports parasite energy requirements, pyrimidine and ubiquinone biosynthesis and [Fe-S] formation. As parasites transition from the host liver to asexual and sexual blood stages, metabol...
Spatiotemporal dynamics of signal dependent exocytosis and parasitophorous vacuolar membrane rupture during Plasmodium falciparum egress [0.03%]
恶性疟原虫释放过程中信号依赖性胞外泌和寄生虫包囊膜破裂的时空动态过程
Watcharatip Dedkhad,Tia Tran,Manuel A Fierro et al.
Watcharatip Dedkhad et al.
Malaria, caused by intracellular Plasmodium falciparum parasites, remains a major global health concern. These parasites reside and replicate within a vacuole in host red blood cells. Egress of daughter parasites out of the vacuolar and hos...
Platelet-leucocyte interactions drive MMP-mediated tissue damage in tuberculosis [0.03%]
血小板-白细胞相互作用通过基质金属蛋白酶介导的组织损伤在结核病发展中起关键作用
Daniela E Kirwan,Deborah L W Chong,Oscar Gayoso et al.
Daniela E Kirwan et al.
Tuberculosis causes inflammation and excess matrix metalloproteinase (MMP) activity which lead to tissue damage and adverse patient outcomes. Platelets are emerging as key drivers of inflammation, and platelet-leucocyte aggregate formation ...
Playing both sides - Epstein-Barr Virus accumulates select cellular transcripts to counter virus-mediated host shut-off in lytic cells [0.03%]
双面间谍作用——Epstein-Barr病毒在裂解细胞中选择性积累宿主信使核糖核酸以对抗病毒介导的宿主基因沉默作用
Derek Daigle,Ashton Creasy-Marrazzo,Lyn Gradoville et al.
Derek Daigle et al.
Epstein-Barr virus (EBV), an oncogenic virus, actively remodels the intracellular environment during its lytic (replicative/productive) phase to facilitate genome replication, virion packaging, and egress while attempting to evade immune re...
LP.8.1-directed COVID-19 mRNA vaccines durably boost neutralizing antibodies and mitigate ancestral immune imprinting [0.03%]
针对COVID-19的mRNA疫苗LP.8.1可持久增强中和抗体并缓解对祖先毒株的免疫印记效应
Ian A Mellis,Madeline Wu,Hsiang Hong et al.
Ian A Mellis et al.
As SARS-CoV-2 evolves, it evades existing immunity elicited by exposure to earlier strains of the virus. In response, vaccine manufacturers have updated COVID-19 vaccines annually since 2022, though immune imprinting to the ancestral strain...
Excessive C5 conversion prevents C9 polymerisation and subsequent MAC-dependent killing of Klebsiella pneumoniae [0.03%]
过量的C5转化可阻止克雷伯氏菌肺炎胞浆多糖的C9聚合及其依赖MAC的杀灭作用
Kulsum M Dawoodbhoy,Coco R Beudeker,Panagiotis Theofilidis et al.
Kulsum M Dawoodbhoy et al.
Membrane Attack Complex (MAC) pores are important in the human innate immune response to directly kill pathogenic Gram-negative bacteria. MAC pores assemble when complement proteins in serum are activated on bacteria and convert complement ...
Diversity and evolution of a phase-variable multi-locus antigen in Neisseria gonorrhoeae [0.03%]
淋病奈瑟菌多态可变的多重基因座抗原的多样性及进化
QinQin Yu,Tatum D Mortimer,Sofia O P Blomqvist et al.
QinQin Yu et al.
Neisseria gonorrhoeae is a sexually transmitted bacterial pathogen that deploys multiple mechanisms to evade the immune system, including rapid variation in surface antigens. One of the most abundant and diverse antigens are members of the ...
Toxoplasma IMC1 is a central component of the subpellicular network and plays critical roles in parasite morphology, replication, and infectivity [0.03%]
弓形虫IMC1是亚皮层网络的核心组分并在病原体形态、复制和感染中发挥关键作用
Juliette N Uy,Qing Lou,Z Hong Zhou et al.
Juliette N Uy et al.
Toxoplasma gondii and related apicomplexan parasites utilize a unique membrane and cytoskeletal organelle called the inner membrane complex (IMC) for maintaining cell shape, motility, host cell invasion, and replication. The cytoskeleton po...
A circular RNA vaccine induces durable and cross-protective immunity against Neisseria meningitidis serogroup B in mice [0.03%]
一种圆环状DNA疫苗可诱导持久的、交叉保护的小鼠脑膜炎球菌抗体免疫应答
Qiqi Zhang,Dongyu Niu,Yusheng Jia et al.
Qiqi Zhang et al.
Neisseria meningitidis serogroup B (MenB) remains a major global cause of meningitis and septicemia. However, MenB vaccine development is hindered by antigenic diversity and manufacturing challenges associated with outer membrane vesicles (...
Host species-specific mutations in the thumb domain of the 3Dpol polymerase are required for efficient replication of human hepatitis A virus in mice [0.03%]
人戊型肝炎病毒高效感染小鼠需要特异的拇指结构域突变以适应新宿主
Ichiro Misumi,Takayoshi Shirasaki,Ling Xie et al.
Ichiro Misumi et al.
Hepatitis A virus (HAV) is a globally important cause of enterically-transmitted hepatitis. It is one of 9 distinct Hepatovirus species in the Picornaviridae, among which phylogenetic reconstructions suggest multiple past host species jumps...