Cryptosporidium secreted proteins form a complex layered interface with the host cell [0.03%]
Cryptosporidium分泌蛋白形成具有层次结构的复合物并作用于宿主细胞界面
Annet Puthenpurackal,Sandra Moreno Sanchez,Tifany Schaer et al.
Annet Puthenpurackal et al.
Cryptosporidium parvum, one of the leading causes of diarrheal death in children, remodels its infection site through secreted effector proteins. Several of them accumulate at the host-parasite interface, forming a complex structure whose f...
How resistance-nodulation-division (RND) efflux pumps contribute to virulence [0.03%]
阻力-结节-分裂（RND）外排泵的毒力贡献机制研究进展
Corrella S Detweiler,Ilyas Alav
Corrella S Detweiler
In Gram-negative bacteria, multi-subunit efflux pumps transport molecules across the inner membrane, periplasm, and outer membrane to the extracellular environment. These efflux pumps include the Resistance-Nodulation-Cell Division (RND) su...
Collectin-11, a complement pattern recognition molecule, mediates pulmonary SARS-CoV-2 neutralization and protection [0.03%]
补体识别分子 Collectin-11 能介导肺部新冠病毒中和与保护作用
Adrian Sutta,Anna Offersgaard,Carlos Rene Duarte Hernandez et al.
Adrian Sutta et al.
Background: Collectin-11 (CL-11) is a complement-activating pattern recognition molecule with structural and functional similarities to mannose-binding lectin (MBL), produced in different tissues, including lung epitheliu...
Chemical genetics reveals Leishmania KKT2 and CRK9 kinase activity is required for cell cycle progression [0.03%]
化学遗传学揭示利什曼原虫KKT2和CRK9激酶活性对于细胞周期进程是必需的
Juliana B T Carnielli,James A Brannigan,Priscila Z Ramos et al.
Juliana B T Carnielli et al.
Protein kinases are key regulators of the eukaryotic cell cycle and have consequently emerged as attractive targets for drug development. Their well-defined active sites make them particularly amenable to inhibition by small molecules, unde...
Poliovirus 3Dpol polymerase region is essential for cleavage of poliovirus 3AB in vivo [0.03%]
脊髓灰质炎病毒3Dpol聚合酶区是体内切分脊髓灰质炎病毒3AB所必需的区域
Minetaro Arita
Minetaro Arita
Poliovirus (PV) genome encodes a large single polyprotein that is processed by viral proteases to form an active replication complex through either cis or trans interactions between the viral proteins (i.e., interactions between viral prote...
Tristetraprolin attenuates schistosomiasis-induced liver fibrosis through m⁶A-mediated regulation of TGF-β1 mRNA stability [0.03%]
Tristetraprolin通过m6A介导的TGF-β1 mRNA稳定性调控抑制肝纤维化
Xuejun Zhao,Xinyi Wang,Kejun Liu et al.
Xuejun Zhao et al.
Inhibiting the activation of hepatic stellate cells (HSCs) represents a key therapeutic strategy for alleviating liver fibrosis induced by schistosomiasis. Diverse cell populations secrete pro-inflammatory cytokines and chemokines, which in...
Leptospiral dissemination is restrained by liver macrophages through Clec4d-driven capture via C/EBPβ activation [0.03%]
肝巨噬细胞通过激活Clec4d介导的捕获来限制钩端螺旋体的播散
Xi Chen,Xin Liu,Jiuxi Liu et al.
Xi Chen et al.
Leptospirosis, caused by pathogenic Leptospira species, is a globally significant zoonotic disease with high morbidity and mortality. However, the organs or cells mainly involved in capturing circulating leptospires and the related mechanis...
Host-specific platelet-activating factor acetylhydrolase selectively remodels diacylglycerophospholipids to control schistosome development [0.03%]
门控血吸虫发育的宿主特异性血小板活化因子乙酰水解酶选择性重塑二酰基甘油磷脂酸酯
Johanna Ertl,Ulrich Fabien Prodjinotho,Zhigang Rao et al.
Johanna Ertl et al.
Background: Schistosomiasis, one of the most prevalent neglected tropical diseases, is treated exclusively with praziquantel, which targets only adult worms. High reinfection rates and the potential emergence of drug resi...
Extensive diversity and impact of drug-resistant HIV-1 variants in individuals with prior virologic failure [0.03%]
多重病毒学失败的HIV-1感染者中耐药HIV-1变体的多样性和影响
Melendhran Pillay,Manish C Choudhary,Rinki Deo et al.
Melendhran Pillay et al.
HIV-1 drug resistance remains a major challenge to treatment and control efforts, particularly in sub-Saharan Africa (sSA). However, standard resistance genotyping does not adequately capture linked drug resistance mutations within the vira...
Retraction: The Uptake of Apoptotic Cells Drives Coxiella burnetii Replication and Macrophage Polarization: A Model for Q Fever Endocarditis [0.03%]
撤稿：凋亡细胞的吞噬驱动恙热库克斯体的复制和巨噬细胞极化：恙发热性心内膜炎的模型
PLOS Pathogens Editors
PLOS Pathogens Editors