Tripartite motif-containing 34 (TRIM34) protein interacts with the nucleocytoplasmic transport machinery and negatively modulates antiviral responses [0.03%]
三聚体基序含有的34号蛋白与核质运输机制互作并下调抗病毒反应
Paula Vázquez-Utrilla,Vanessa Rivero,Marta L DeDiego
Paula Vázquez-Utrilla
The tripartite motif-containing (TRIM) 34 protein is an interferon (IFN)-induced protein whose expression is upregulated after influenza A virus (IAV) infection. Here, we identify a previously unknown function for TRIM34 as a negative regul...
β-Klotho inhibited the epithelial-mesenchymal transition of liver sinusoidal endothelial cells to alleviate schistosomiasis liver fibrosis [0.03%]
Klotho通过抑制肝窦内皮细胞上皮间质转化来缓解血吸虫病肝纤维化
Tingting Jiang,Qiang Li,Zhihao Yu et al.
Tingting Jiang et al.
Schistosomiasis is a neglected zoonotic disease, and the liver fibrosis induced by Schistosoma japonicum infection poses a significant threat to human health. Traditionally, liver fibrosis in schistosomiasis has been attributed to eggs depo...
Update and reuse: Structure-guided nanobody evolution against SARS-CoV-2 escape [0.03%]
结构指导的纳米抗体进化以应对SARS-CoV-2的逃逸
Fan Bu,Divyasha Saxena,Hailey Turner-Hubbard et al.
Fan Bu et al.
SARS-CoV-2 continues to accumulate spike mutations that erode the efficacy of antibody therapeutics. The Q493E mutation in the spike RBD, present in recent Omicron subvariants, enables escape from many antibodies and nanobodies, including o...
The RNA promoter for pathogenic orthoflaviviruses replication is universal and serves as target for viral inhibition [0.03%]
致病性正黄病毒RNA复制启动子具有通用性和靶向性的抗病毒作用
Santiago Oviedo-Rouco,Lautaro Bertoni,Evelyn Mikkelsen et al.
Santiago Oviedo-Rouco et al.
Orthoflaviviruses comprise a diverse genus of positive-strand RNA viruses that includes major human pathogens such as dengue, yellow fever, Zika, Japanese encephalitis, tick-borne encephalitis, and West Nile viruses. Despite their global im...
FUT8-mediated core fucosylation of receptor APN drives entry of multiple alphacoronaviruses [0.03%]
受体APN上由FUT8介导的核心岩藻糖基化驱动多种α冠状病毒的进入
Limeng Sun,Yixin Xiang,Yichen Yang et al.
Limeng Sun et al.
Understanding the interaction mechanisms between coronaviruses (CoVs) and their hosts is crucial for understanding the viral replication cycle and identifying novel antiviral targets. In this study, we found alpha-(1,6)-fucosyltransferase (...
HCMV-pUS2 Disrupts cGAS-STING Signaling through LMAN2L Degradation [0.03%]
人巨细胞病毒pUS2通过降解LMAN2L干扰cGAS-STING信号通路
Yue-Peng Zhou,Yong-Xuan Yao,Jin-Peng Wu et al.
Yue-Peng Zhou et al.
Human cytomegalovirus (HCMV) has evolved diverse strategies for immune evasion. In this study, we identified HCMV-pUS2 as an indirect antagonist of the cGAS-STING pathway by promoting the degradation of lectin mannose-binding 2-like protein...
Nuclear transport of cytomegalovirus tegument protein pp65 through nucleoplasmic reticulum [0.03%]
巨细胞病毒衣壳蛋白pp65通过胞质网进入细胞核
Maysa Azzeh,Mark F Santos,Alexandra M K Yokomizo et al.
Maysa Azzeh et al.
Human cytomegalovirus (HCMV) is a widespread beta-herpesvirus that establishes lifelong infection and can cause severe disease in immunocompromised individuals as well as congenital abnormalities. While HCMV entry into fibroblasts is classi...
The carbon starvation-inducible lipoprotein (Slp) influences differential adherence of Escherichia coli O157:H7 at the bovine rectoanal junction [0.03%]
副养活诱导脂蛋白(Slp)影响O157:H7在牛直肠肛门结合部的黏附差异性
Indira T Kudva,Erika N Biernbaum,Eric D Cassmann et al.
Indira T Kudva et al.
Shiga toxin-producing Escherichia coli O157:H7 (O157), a foodborne human pathogen, persists at the rectoanal junction (RAJ) of the bovine intestinal tract, in asymptomatic cattle reservoirs. Identifying mechanisms used by O157 for initial a...
Acetylation-mediated regulation of ALV viral proteins: Implications for retroviral inhibition [0.03%]
乙酰化介导的ALV病毒蛋白调节：对逆转录病毒抑制的影响
Ning Cui,Xiaoxia Han,Qinghua Huang et al.
Ning Cui et al.
Avian leukosis virus (ALV), a prototypic alpharetrovirus, serves as a pivotal model for studying retroviral biology due to its well-characterized replication cycle, genetic tractability, and evolutionary conservation with clinically relevan...
Characterization of the virus-host RNA-RNA interactome across important human pathogenic RNA viruses [0.03%]
重要的人类致病RNA病毒的病毒-宿主RNA-RNA互作组特征分析
Nkerorema Djodji Damas,Stefan E Seemann,Rui Costa et al.
Nkerorema Djodji Damas et al.
Viruses make extensive use of host cell machinery, however, most systematic studies of virus-host interactions focused on proteins with less attention to nucleic acids. RNA plays important roles in storing, conveying, and regulating genetic...