Flipping the script: Using mucosal immune obstacles to inform vaccine design [0.03%]
转变思维：利用粘膜免疫障碍来指导疫苗设计
Avan Antia,Siyuan Ding
Avan Antia
Editorial Note: Recruitment of a SAP18-HDAC1 Complex into HIV-1 Virions and Its Requirement for Viral Replication [0.03%]
编者按：SAP18-HDAC1复合体招募至HIV-1衣壳及其对病毒复制的调控作用
PLOS Pathogens Editors
PLOS Pathogens Editors
A murine cytomegalovirus cell cycle regulator (m54.5p) evolved within the conserved viral DNA polymerase gene [0.03%]
一种小鼠巨细胞病毒细胞周期调节基因(m54.5p)在保守的病毒DNA聚合酶基因内进化而来
Yan Zheng,Ivana Bertovic,Xiangming Han et al.
Yan Zheng et al.
Ribosome profiling (Ribo-seq) and transcription start site profiling recently unveiled hundreds of novel viral gene products in lytic murine cytomegalovirus (MCMV) infection. One of these is the highly expressed m54.5 open reading frame (OR...
Equine infectious anemia virus blocks interferon responses through Rev-mediated activation of the stress granule-PKR-eIF2α pathway [0.03%]
Rev介导的马传染性贫血病毒通过激活应激颗粒-PKR-eIF2α途径阻断干扰素反应
Huiling Ren,Kewei Chen,Bingqian Zhou et al.
Huiling Ren et al.
Type I interferons (IFNs) play a pivotal role in antiviral defence by inducing interferon-stimulated genes (ISGs) that target multiple stages of viral replication. Equine infectious anemia virus (EIAV) is an ancient lentivirus that establis...
Structural basis for sarbecovirus Rc-o319 spike adaptation to Rhinolophus cornutus Bat ACE2 and constraints on switching to human ACE2 [0.03%]
萨贝科病毒Rc-O319刺突适应于多毛大耳蝠ACE2及其切换至人ACE2的制约因素的结构基础
Jingjing Wang,Zexuan Li,Yong Ma et al.
Jingjing Wang et al.
Bat sarbecoviruses often exhibit species-dependent ACE2 specificity. Understanding the determinants of receptor specificity enables better assessment of the cross-species transmission potential of sarbecoviruses. Here, we characterize the S...
The hyaluronan receptor CD44 drives COVID-19 severity through its regulation of neutrophil migration [0.03%]
透明质酸受体CD44通过调节中性粒细胞迁移驱动COVID-19的严重程度
Duncan J Hart,Md Jashim Uddin,Rebecca J Dodd et al.
Duncan J Hart et al.
The novel respiratory disease COVID-19 caused by the coronavirus SARS-CoV-2 continues to be a public health emergency worldwide, and there is a need for more effective therapy for patients. The relationship between the extracellular matrix ...
Characterization of a novel cell wall-associated nucleotidase of Enterococcus faecalis that degrades extracellular c-di-AMP [0.03%]
耐药菌肠球菌的一种新型细胞壁相关核酸外切酶降解胞外c-di-AMP的机理研究
Adriana G Morales Rivera,Anju Bala,Leila G Casella et al.
Adriana G Morales Rivera et al.
Enterococcus faecalis is a prolific opportunistic pathogen responsible for a range of life-threatening infections, notorious for its ability to withstand environmental stressors. Second messengers are small molecules that relay signals in r...
p1/s1, a 3'-nucleotidase/nuclease, allows Leishmania major to circumvent host innate immune response mechanisms [0.03%]
莱什曼原虫P1/S1蛋白通过水解宿主免疫复合物的DNA来逃避免疫反应
Stella M Schmelzle,Michaela Bergmann,Bianca Walber et al.
Stella M Schmelzle et al.
3'-nucleotidases/nucleases, distinct class I nucleases of protozoan parasites, play a pivotal role in extracellular purine salvage. As Leishmania are purine auxotrophs and lack de novo synthesis, ectoenzymes facilitating nucleotide and nucl...
Roberta Genova,Ashleigh Holmes,Mario Cano-Muñoz et al.
Roberta Genova et al.
Plant pathogens possess about twice as many chemoreceptors as the bacterial average, suggesting broad chemotactic capacities. The signals recognized by most phytopathogen chemoreceptors are unknown, and the reasons for this elevated chemore...
The Nipah virus threat in India: Epidemiological trends, risk drivers, and lessons for pandemic preparedness [0.03%]
印度 nipah 病毒威胁：流行病学趋势、风险驱动因素及大流行准备工作的经验教训
Apoorva;Sunit K Singh
Apoorva;Sunit K Singh
Nipah virus (NiV), a WHO-priority zoonotic pathogen, poses a recurrent public health threat in India. Since its initial detection in 2001, India has encountered multiple NiV spillover events, including repeated outbreaks in Kerala and recen...