Calcineurin-dependent 20E signaling pathway enhances attacin expression to prime the immunity of Helicoverpa armigera against Bacillus thuringiensis Cry1Ac toxin [0.03%]
钙调神经磷酸酶依赖的20E信号途径增强天蚕蛋白表达以激发棉铃虫对苏云金芽孢杆菌Cry1Ac毒素的免疫反应
Xue Yao,Pin Li,Yuge Zhao et al.
Xue Yao et al.
Enhancing the insecticidal efficacy of Bacillus thuringiensis (Bt) toxins by suppressing the immune responses of target insects can simultaneously augment the effectiveness of Bt-based products and address the growing issue of resistance. O...
Novel insights into tomato leaf curl New Delhi virus introduction and evolution in Southeastern France using an advanced long-read sequencing workflow [0.03%]
使用先进的长读测序工作流程对番茄卷叶新德里病毒在法国东南部的引入和进化提供新的见解
Atiwich Patthamapornsirikul,Victor Golyaev,Eric Verdin et al.
Atiwich Patthamapornsirikul et al.
The Mediterranean population of tomato leaf curl New Delhi virus (ToLCNDV-ES) is characterized by a high genetic uniformity, distinguishing it from its Asian counterparts. ToLCNDV-ES is thought to have a monophyletic origin, likely resultin...
Wastewater surveillance as an early warning system for fungal pathogens [0.03%]
废水监测作为真菌病原体早期预警系统的一种方法
Pooja Padmakumar,Adam Winrow,Pilvi Hepo-Oja et al.
Pooja Padmakumar et al.
Intact architectures of myophage phi92 in extended and contracted states [0.03%]
完整的myophage phi92的延长态和收缩态结构
Yuan Chen,Yuning Peng,Yuanyuan Liu et al.
Yuan Chen et al.
Since conventional antibiotics frequently fail to effectively treat infections caused by encapsulated bacteria, phage therapy has gained attention as a potential treatment approach. However, the understanding of phages that can specifically...
hnRNPC facilitates coronavirus replication by directly binding the frameshift-stimulatory element of viral genomic RNA [0.03%]
hnRNPC通过直接结合冠状病毒基因组RNA的移码刺激元件促进冠状病毒复制
Jingchen Xu,Hongying Li,Jianrui Li et al.
Jingchen Xu et al.
Translation of key viral replicative proteins in coronaviruses requires a programmed -1 ribosomal frameshifting (-1 PRF) event controlled by the viral frameshift-stimulatory element (FSE). Although previous studies have analyzed host factor...
A novel dimerization site in non-structural protein 5A of hepatitis C virus regulates viral replication fitness [0.03%]
丙型肝炎病毒非结构蛋白5A一个新的二聚化位点可调节病毒复制的适配性
Paul Rothhaar,Thibault Tubiana,Colin Förster et al.
Paul Rothhaar et al.
We previously found that high genome replication fitness of the hepatitis C virus (HCV) was associated with severe disease in immunocompromised patients. Elevated replication fitness was mediated by accumulation of mutations in the replicat...
TREM2 plays a critical role in innate immune defense against acute Toxoplasma gondii infection by promoting macrophage antimicrobial activities [0.03%]
TREM2通过促进巨噬细胞的抗菌活性在急性弓顶贾第鞭毛虫感染的先天免疫防御中发挥关键作用
Hannah Z Debray,Dillon Cheng,L Angel Ayala et al.
Hannah Z Debray et al.
The TREM2 receptor is a well-known rheostat for inflammation and immunity, but its role in host defense against parasitic infection is only just emerging. We investigated the function of TREM2 during acute Toxoplasma gondii infection by com...
Downregulation of GSDMB by EBV-encoded miR-BART12-3p suppresses killer lymphocyte-mediated pyroptosis in gastric cancer cells [0.03%]
EB病毒编码的miR-BART12-3p通过下调GSDMB抑制胃癌细胞的杀手淋巴细胞介导的焦亡作用
Mingqian Xu,Shijia Hao,Shenlong Huang et al.
Mingqian Xu et al.
Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) is a distinct subtype of gastric cancer (GC) with characteristic clinicopathological and molecular features. EBVaGC exhibits a more extensive lymphocyte infiltration than EBV-negat...
Single amino acid substitution in RdRp reduces viral recombination frequency of NADC30-like porcine reproductive and respiratory syndrome virus type 2 [0.03%]
RdRp单氨基酸替代可降低NADC30样猪繁殖与呼吸综合征病毒2型的重组频率
Xingyang Cui,Hao Song,Xinyi Huang et al.
Xingyang Cui et al.
Porcine reproductive and respiratory syndrome (PRRS) is one of the most significant diseases, causing tremendous economic losses to the global swine industry. Accumulating evidence indicates that recombination between PRRSV-2 strains, parti...
Epigenetic and metabolic reprogramming of innate immune cells establishes immunological memory in the Schistosomiasis vector snail Biomphalaria glabrata [0.03%]
Establishes免疫记忆的表观遗传和代谢重编(Programmed)先天免疫细胞在血吸虫病载体螺Biomphalaria glabrata中
Rémi Pichon,Silvain Pinaud,Cristian Chaparro et al.
Rémi Pichon et al.
Innate immune memory enables non-vertebrates to mount faster and more effective immune responses upon re-exposure to a previously encountered pathogen, yet its cellular and molecular bases remain poorly understood. The freshwater snail Biom...