The 3C-like serine protease activity of porcine astrovirus nsP1a/3 mediates mitochondrial apoptosis and MAVS cleavage to facilitate viral replication and antagonize type I interferon response [0.03%]
猪Astrovirus nsP1a / 3的类似人的3C样丝氨酸蛋白酶活性介导线粒体凋亡和MAVS裂解以促进病毒复制并拮抗I型干扰素反应
YiYang Du,Yueqing Lv,Xiaoying Feng et al.
YiYang Du et al.
Porcine astrovirus (PAstV) is globally prevalent in swine and is associated with diarrhea and encephalitis in piglets, posing a threat to porcine health. However, its pathogenic mechanisms remain poorly understood. This study used the PAstV...
NS5-targeting nucleoside analogs inhibit dengue virus and other flaviviruses [0.03%]
以NS5为目标的核苷类似物可抑制登革病毒及其他黄病毒
Priyanka Bhakt,Swechha M Pokharel,Yue Li et al.
Priyanka Bhakt et al.
Dengue virus (DENV) is a mosquito-transmitted flavivirus that circulates globally as four distinct serotypes and poses a substantial threat to public health. There are an estimated ~96 million symptomatic infections yearly, including severe...
Zoological transmission of encephalomyocarditis virus in the United States: Virus evolution, host ecology, and capsid antigenicity derived from an outbreak [0.03%]
美国啮齿动物中脊髓灰质炎病毒的自然传播：来自一次爆发的病毒进化、宿主生态和衣壳抗原性研究
Aastha Adhikari,Kurtis H Feng,Ayusha Shrestha et al.
Aastha Adhikari et al.
Encephalomyocarditis virus (EMCV) is a rodent-borne picornavirus that has repeatedly caused severe outbreaks resulting in the deaths of zoo mammals - most notably elephants - for decades. However, within North America, little is known regar...
Structural basis for recognition of Rift Valley fever virus Gn protein by a human neutralizing monoclonal antibody with a kappa light chain [0.03%]
人源性抗肯尼塔克裂谷热病毒Gn蛋白单克隆抗体的结构基础研究
Guido C Paesen,Nathaniel S Chapman,Jonna B Westover et al.
Guido C Paesen et al.
Rift Valley fever virus (RVFV) poses a continued threat to human health and animal husbandry. Two neutralizing and protective human monoclonal antibodies (mAbs), RVFV-268 and RVFV-379, exhibit similar affinities and epitope footprints on th...
Expression of Concern: Effects of Capsular Polysaccharide amount on Pneumococcal-Host interactions [0.03%]
表达关切：荚膜多糖含量对肺炎链球菌宿主相互作用的影响
PLOS Pathogens Editors
PLOS Pathogens Editors
Csep1P protein from Campylobacter concisus induces a chemokine-dominant inflammatory state in macrophages and enhances proinflammatory response to gut bacteria [0.03%]
弯曲菌锥形单胞菌CSEP1P蛋白可诱导巨噬细胞产生以趋化因子为主的炎症反应并增强肠道细菌的促炎作用
Christopher Yau Man Luk,Mohammad M Rahman,Xiaotian Zhou et al.
Christopher Yau Man Luk et al.
Translocation of Campylobacter concisus from the oral cavity to the intestinal tract is increasingly recognised as a contributor to inflammatory bowel disease (IBD). The C. concisus secreted protein Csep1 has emerged as a molecular marker o...
A type III secretion system is required for Bordetella atropi invasion of host cells in vivo [0.03%]
百日咳博德特菌的一种III型分泌系统是其感染宿主细胞所必需的
Tuan D Tran,Serena J Meadows-Graves,Amanda R Haio et al.
Tuan D Tran et al.
Bordetella atropi is an intracellular bacterial pathogen that infects the intestinal epithelia of the nematode host Oscheius tipulae. We previously showed that the bacteria use filamentation as a novel cell-to-cell spreading mechanism once ...
It's not me, it's you: Anti-phage nuclease specificity inside a bacterium [0.03%]
不是我，是你：细菌体内的抗噬菌体核酸内切酶特异性
Alex Hong,Joseph Bondy-Denomy
Alex Hong
MYSM1-mediated epigenetic modification dysregulation leads to immunosuppression and secondary infections in sepsis [0.03%]
MYSM1介导的表观遗传修饰失调导致脓毒症相关免疫抑制和二次感染
Jiali Xiong,Xin Cheng,Xiaoxing Xiong et al.
Jiali Xiong et al.
Sepsis is a life-threatening condition characterized by a dysregulated immune response to infection, often leading to organ dysfunction and even death. During the recovery phase of sepsis, patients frequently exhibit impaired antimicrobial ...
The UBC/SIRT5/DRP1 axis regulates mitochondrial dynamics to alleviate Staphylococcus aureus-induced oxidative stress and senescence in bovine mammary epithelial cells [0.03%]
UBC/SIRT5/DRP1轴调节线粒体动力学以缓解金黄色葡萄球菌诱导的氧化应激和牛乳腺上皮细胞衰老
Huijie Hu,Naiyuan Jiang,Juxiong Liu et al.
Huijie Hu et al.
Staphylococcus aureus (S. aureus)-driven senescence of bovine mammary epithelial cells is a key determinant of mammary gland health, yet its molecular basis remains poorly defined. Sirtuin 5 (SIRT5), a mitochondria-localized desuccinylase, ...