Aida Bahrami,Cheryl Walter,Amin Ardestani
Aida Bahrami
The Hippo signalling pathway has emerged as an important regulator of host-virus interactions, linking antiviral immunity, viral replication, inflammation, and tissue remodelling. Recent studies show that upstream Hippo kinases such as MST1...
Exposure to herbivore-induced plant volatiles primes JA-dependent gossypol defenses in cotton [0.03%]
昆虫啃食诱导的植物挥发物活化棉花中的茉莉酸依赖性棉酚防御反应
Chuanyu Zhu,Chengcheng Yao,Runxiao Liu et al.
Chuanyu Zhu et al.
Herbivore-induced plant volatiles (HIPVs) are known to prime neighboring plants for enhanced defense, but the molecular basis for this phenomenon remains poorly understood, particularly in cotton. Here, we demonstrate for cotton plants that...
SV40 exploits the Nesprin-2-SUN1-KPNA4 axis for stepwise targeting and entry into the host nucleus to promote infection [0.03%]
SV40利用Nesprin-2-SUN1-KPNA4轴逐步定位并进入宿主细胞核以促进感染
Luke Gohmann,Billy Tsai
Luke Gohmann
Many DNA viruses including polyomaviruses (PyVs) enter the host nucleus to cause infection, although how this is accomplished is unclear. To infect cells, the prototype PyV SV40 targets to the Nesprin-2 outer nuclear membrane protein and en...
Understanding the impact of Klebsiella pneumoniae K-Antigen based MAPS vaccine design on the immune response in animal models [0.03%]
基于Klebsiella肺炎克雷伯氏菌K抗原的MAPS疫苗设计对动物模型免疫反应的影响研究
Elena Palmieri,Gianina Florentina Belciug,Francesca Nonne et al.
Elena Palmieri et al.
MAPS technology represents an innovative approach for the development of polysaccharide-based vaccines, relying on the affinity interaction between biotin and rhizavidin (rhavi), with potential for enhanced coverage through the incorporatio...
A chemical bactericide dioctyldiethylenetriamine (Xinjunan) exerts a non-lethal effect by inhibiting RpfG activity to regulate the quorum sensing system [0.03%]
化学杀菌剂双辛基二亚乙基三胺（新君南）通过抑制RpfG活性调控群体感应系统而发挥非致死效应
Ling Jin,Xing Chen,Chaoyue Pang et al.
Ling Jin et al.
Bacterial diseases pose a major threat to global agriculture and food security. Bactericides are highly effective in disease control due to their direct antibacterial effect. However, it causes "life or death" selection pressure on the targ...
Downregulation of miR-10b-3p by EBV promotes tumor growth and metastasis via ITGAV in nasopharyngeal carcinoma [0.03%]
Epstein-Barr病毒通过下调miR-10b-3p促进鼻咽癌细胞的增殖浸润及转移ITGAV轴的作用机制研究
Yu Zhang,Yaoqiang Shi,Yingdong Zou et al.
Yu Zhang et al.
Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor strongly associated with Epstein-Barr virus (EBV) infection. EBV-mediated dysregulation of host microRNAs (miRNAs) contributes to NPC pathogenesis, but the functions of many EBV...
Correction: Molecular response to the non-lytic peptide bac7 (1-35) triggers disruption of Klebsiella pneumoniae biofilm [0.03%]
订正：非溶菌肽bac7（1-35）的分子反应引发克雷伯氏肺炎杆菌生物膜破裂
Robert L Beckman I V,Berta Victoria,Flor Z Santiago et al.
Robert L Beckman I V et al.
[This corrects the article DOI: 10.1371/journal.ppat.1013437.]. Copyright: © 2026 Beckman I. V et al. This is an open access article distributed under t...
Published Erratum
PLoS pathogens. 2026 Jun 9;22(6):e1014298. DOI:10.1371/journal.ppat.1014298 2026
Low frequency variants can predetermine antiviral drug resistance development in herpes simplex virus type 1 [0.03%]
低频变异可通过决定单纯性疱疹病毒1型的药物抗性发展起重要作用
Lena Jaki,Florian Full,Udo Gieraths et al.
Lena Jaki et al.
Severe HSV-1 disease is treated with potent antiviral drugs, in particular aciclovir (ACV) and its derivatives. However, long-term drug exposure in immunocompromised patients can lead to the emergence of ACV-resistant HSV-1 strains and clin...
Inhibition of high risk HPV31 E8^E2 repressor activity enables differentiation-independent genome amplification and E4 expression [0.03%]
抑制高危HPV31 E8^E2阻遏活性可使其在分化独立的细胞中完成基因组扩增和E4表达
Tina Melanie Rehm,Elke Straub,John Doorbar et al.
Tina Melanie Rehm et al.
Persistent infections with high-risk human papillomaviruses (HPV) can result in different malignancies. Productive replication of HPV is normally restricted to suprabasal keratinocytes that have entered terminal differentiation and is chara...
The Legionella pneumophila type IVb secretion system effector BinA subverts amino acid transport to sensitize TORC1 signaling in macrophages [0.03%]
Legionella pneumophila 类 IVB 分泌系统效应蛋白 BinA 可劫持氨基酸转运，使宿主 mTORC1 信号在巨噬细胞内敏感化
Magdalena Circu,Reneau Castore,Brian Latimer et al.
Magdalena Circu et al.
Legionella pneumophila is an environmental Gram-negative bacterium that parasitizes unicellular protozoa and can cause severe pulmonary infections when aerosolized bacteria are inhaled by humans. One critical aspect of Legionella pathogenes...