An ER-IMC bridge protein TgVPS13A and an IMC-resident scramblase TgDAT1 drive daughter budding in Toxoplasma gondii [0.03%]
顶体蛋白TgVPS13A和内膜复合物驻留蛋白TgDAT1驱动刚地弓形虫子孢子胞芽生成
Lin Zhao,Jiawen Fu,Swaroop Peddiraju et al.
Lin Zhao et al.
All alveolates including apicomplexan parasites contain an inner membrane complex (IMC) underneath the plasma membrane. The IMC is synthesized de novo during asexual replication (including endodyogeny, endopolygeny, and schizogony) and serv...
Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs [0.03%]
基于化学组学的pipeline用于发现朊病毒突触毒理通路及抑制药物
Nhat T T Le,Robert C C Mercer,Cheng Fang et al.
Nhat T T Le et al.
Prion propagation, in which the cellular prion protein (PrPC) is conformationally converted into an infectious structure (PrPSc), has been extensively studied. However, the molecular mechanism responsible for the neurotoxicity of prions rem...
Emerging fungal threats from the environment-a lesson from Candida auris and a warning about a second candidate, Rhodosporidiobolus fluvialis [0.03%]
环境中的新发真菌威胁——从耳蜗念珠菌学到的一课和关于第二个候选人的警告：Rhodosporidiobolus fluvialis
Yeseul Choi,Joseph Heitman,Eun Jeong Won
Yeseul Choi
Ovoid cell is an inducible small-sized morphotype that enhances proliferation and antifungal drug tolerance in the human fungal pathogen Cryptococcus neoformans [0.03%]
卵圆形细胞是新生隐球菌的一种诱导产生的小型表型，可增强其增殖能力和抗真菌药耐受性
Xitong Zhang,Xiaoji Shu,Ya Liu et al.
Xitong Zhang et al.
Cryptococcus neoformans is the leading cause of fungal meningoencephalitis. Cellular heterogeneity during cryptococcal infection contributes to host adaptation and fungal pathogenesis. C. neoformans titan cells and seed cells represent enla...
Erik Fuhrmann,Sae Toda,Jonas Leins et al.
Erik Fuhrmann et al.
Poly(A) tails are present on most cellular and viral mRNAs, providing a platform for poly(A)-binding proteins that stimulate translation and regulate the deadenylation and stability of transcripts in the cytoplasm. Here we leverage nanopore...
Correction: Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts [0.03%]
订正：干扰素刺激基因20（ISG20）选择性降解N6-甲基腺苷修饰的乙型肝炎病毒转录本
Hasan Imam,Geon-Woo Kim,Saiful Anam Mir et al.
Hasan Imam et al.
[This corrects the article DOI: 10.1371/journal.ppat.1008338.]. Copyright: © 2026 Imam et al. This is an open access article distributed under the terms...
Published Erratum
PLoS pathogens. 2026 Jun 16;22(6):e1014336. DOI:10.1371/journal.ppat.1014336 2026
Central Nervous System T-cell immune architecture, and not HIV burden, tracks with cognition under long-term viral suppression [0.03%]
长期病毒抑制下的中枢神经系统T细胞免疫特征而非HIV负荷与认知有关
Mattia Trunfio,Gemma Caballero,Vanessa Gomez-Moreno et al.
Mattia Trunfio et al.
Despite effective antiretroviral therapy, HIV persists in the central nervous system (CNS) and may contribute to neuroinflammation and cognitive impairment. How viral persistence, immune responses, and regional CNS T-cell architecture relat...
Retraction: Plant rhabdovirus glycoprotein activates unfolded protein response-mediated antiviral ER-phagy in insect vectors [0.03%]
撤稿：植物鲨鱼病毒糖蛋白激活昆虫载体中的unfolded蛋白质反应介导的抗病毒内质网自噬
PLOS Pathogens Editors
PLOS Pathogens Editors
Editorial Note: Reoviruses hijack the SMARCB1-MYC transcriptional regulation complex to activate autophagy for persistent viral infection in leafhopper vector [0.03%]
编者按：呼肠孤病毒劫持SMARCB1-MYC转录调控复合体激活自噬以利于飞虱持久性传毒病毒感染
PLOS Pathogens Editors
PLOS Pathogens Editors
The assembly of stress granules during foot-and-mouth disease virus infection is uncoupled from activation of cellular intrinsic antiviral signalling [0.03%]
口蹄疫病毒感染期间应激颗粒的装配与细胞内在抗病毒信号传导激活脱钩
Mariana Marques,Yui Xi Wong,Zhaozhi Sun et al.
Mariana Marques et al.
Foot-and-mouth disease virus (FMDV) is highly contagious among cloven-hoofed animals and poses a major threat to the livestock industry worldwide. A fundamental gap in knowledge for high consequence viruses such as FMDV is understanding how...