Ureaplasma-driven inhibition of the epithelial Na+ transport in fetal alveolar cells: A novel mechanism of Ureaplasma-mediated preterm lung disease [0.03%]
脲原体驱动的胎儿肺泡细胞上皮钠通道转运抑制：脲原体介导的早产儿肺病的新机制研究
Kirsten Glaser,Carl-Bernd Rieger,Elisabeth Paluszkiewicz et al.
Kirsten Glaser et al.
Respiratory tract colonization with Ureaplasma species has been repeatedly associated with the development of acute and long-term pulmonary morbidity in preterm infants. However, despite strong evidence from observational studies and animal...
Valaciclovir therapy for secondary suppression of immune response to herpesviruses: An exploratory study [0.03%]
伐昔洛韦治疗对继发性免疫反应抑制的探索研究：一项针对疱疹病毒的研究
Kirsty McGee,Alex Dowell,Sarah Lauder et al.
Kirsty McGee et al.
Herpesviruses establish a state of persistent infection which is suppressed by sustained virus-specific immune control. The magnitude of this immune response can increase with age and lead to attrition of immune reserve against other pathog...
A wide diversity of viruses detected in African mammals involved in the wild meat supply chain [0.03%]
在非洲野肉供应链中涉及的哺乳动物体内检测到多种病毒
Mare Geraerts,Sophie Gombeer,Casimir Nebesse et al.
Mare Geraerts et al.
The processes involved in acquiring, trading, preparing, and consuming wild meat pose significant risks for the emergence of zoonotic infectious diseases. Several major viral outbreaks have been directly linked to the wild meat supply chain...
Correction: Machine learning-based phenotypic imaging to characterise the targetable biology of Plasmodium falciparum male gametocytes for the development of transmission-blocking antimalarials [0.03%]
纠正：基于机器学习的表型成像，用于表征恶性疟原虫雄性配子体可靶向生物学，以开发传输阻断抗疟药
Oleksiy Tsebriy,Andrii Khomiak,Celia Miguel-Blanco et al.
Oleksiy Tsebriy et al.
[This corrects the article DOI: 10.1371/journal.ppat.1011711.]. Copyright: © 2025 Tsebriy et al. This is an open access article distributed under the te...
Published Erratum
PLoS pathogens. 2025 Dec 29;21(12):e1013814. DOI:10.1371/journal.ppat.1013814 2025
Cyclic-di-GMP controls Type III effector export and symptom development in Pseudomonas syringae infections via the export ATPase HrcN [0.03%]
环二鸟苷酸通过分泌ATP酶HrcN调控假单胞菌致病岛III型效应子分泌及病原细菌感染导致的植物发病症状的发展
Danny Ward,Richard H Little,Catriona M A Thompson et al.
Danny Ward et al.
Pseudomonas syringae is a destructive bacterial pathogen that infects a wide variety of plants. Following apoplastic entry, P. syringae uses its type 3 injectisome (T3I) to secrete host-specific effectors into the cytoplasm, enabling tissue...
Trans-complementation of chikungunya virus replicase mutants reveals alphavirus replication complexity and supports antiviral tool development [0.03%]
基因为工具开发揭示沙粒病毒复制复杂性并支持抗病毒研究的 Chicungunya 病毒复制酶突变体跨互补性
Sainan Wang,Krystyna Naumenko,Mandana Mirzajani Sarvandani et al.
Sainan Wang et al.
Chikungunya virus (CHIKV) is a reemerging alphavirus responsible for large-scale outbreaks in tropical regions. Its RNA replication depends on the assembly of functional replication complexes using the P123 and P1234 polyprotein precursors ...
The early human interferon gamma response to Toxoplasma gondii is driven by Vγ9Vδ2 T-cell sensing of host phosphoantigens and subsequent NK-cell activation [0.03%]
宿主磷抗原感应和自然杀伤细胞活化驱动的托拉螺旋体感染早期的人γδT细胞反应
Felipe Rodriguez,Jeroen P J Saeij
Felipe Rodriguez
Toxoplasma gondii is a globally prevalent intracellular parasite that infects ~40 million Americans. The murine immune response to Toxoplasma relies on both toll-like receptor (TLR) 11/12 and immunity related GTPase-mediated (IRGs) response...
Sclerotinia sclerotiorum growth and aggressiveness are regulated by a mycoviral REP protein [0.03%]
半乳糖凝集素GaLcY通过结合乙酰化赖氨酸调节H3K4甲基转移酶RBR-2招募和RNA聚合酶II介导的转录启动
Peihan Shu,Yi-Wen Tseng,Alexander J Lawrence et al.
Peihan Shu et al.
The mechanisms through which mycoviruses reduce fungal growth and aggressiveness remain unclear, particularly regarding the viral factors involved and their modes of action. In this work, we investigated the hypovirulence mechanism by which...
A conserved enzymatic toolkit targeting host cell metabolism is associated with Cryptococcus neoformans intracellular survival in protozoal and mammalian phagocytic cells [0.03%]
一个保守的酶类工具箱与新生隐球菌宿主细胞代谢有关，该工具箱可使新生隐球菌在原生动物和哺乳动物吞噬细胞中存活
Quigly Dragotakes,Ella Jacobs,Gracen Gerbig et al.
Quigly Dragotakes et al.
The outcome of the interaction between Cryptococcus neoformans and infected hosts can be determined by whether the fungal cell survives ingestion by phagocytic cells. This applies to both unicellular and multicellular hosts such as amoeba a...
Mycobacterium tuberculosis manipulates LINC02528 in macrophages to modulate anti-tuberculosis metabolic immunity [0.03%]
结核分枝杆菌通过操纵巨噬细胞中长链非编码RNA LINC02528调节抗结核代谢免疫反应
Yuzhong Xu,Kehong Zhang,Sinan Li et al.
Yuzhong Xu et al.
Host defenses are crucial in deciding the fate of Mycobacterium tuberculosis (Mtb) infections, as less than 10% of infected individuals develop tuberculosis. Oxidative stress plays a critical role in the host defense against Mtb. However, t...