Pp6-Pfkfb1 axis modulates intracellular bacterial proliferation by orchestrating host-pathogen metabolic crosstalk [0.03%]
PP6-PFKFB1轴通过调控宿主病原体代谢交叉对话来调节胞内细菌增殖
Li Fan,Yang Sun,Fangzhou Lou et al.
Li Fan et al.
Intracellular bacterial pathogens exhibit heterogeneous replication rates within host macrophages, but the mechanisms by which they manipulate host factors for survival remain incompletely understood. Using a fluorescence-dilution reporter ...
Small granule protein CP2 of Cryptosporidium translocates to the parasite-host interface during invasion and localizes to parasitophorous vacuole membrane in association with other secretory proteins [0.03%]
隐孢子虫小颗粒蛋白CP2在感染期间转运至寄生虫-宿主界面并以其他分泌蛋白相关的形式定位到寄生虫包囊膜上
Fuxian Yang,Yujin Huang,Ping Zhu et al.
Fuxian Yang et al.
Cryptosporidium is a major cause of diarrhea in humans and farm animals for which there are no effective drugs. The parasite resides in a parasitophorous vacuole on the surface of gastrointestinal epithelial cells. Although the parasitophor...
Flavivirus NS1-triggered endothelial dysfunction promotes virus dissemination [0.03%]
黄病毒NS1诱发内皮细胞功能障碍促进病毒扩散
Henry Puerta-Guardo,Scott B Biering,Bryan Castillo-Rojas et al.
Henry Puerta-Guardo et al.
The Flaviviridae are a family of viruses that include the important arthropod-borne human pathogens dengue virus (DENV), West Nile virus, Zika virus, Japanese encephalitis virus, and yellow fever virus. Flavivirus nonstructural protein 1 (N...
Host Protein Kinase C⍺: The novel Mitogen Activated Protein Kinase (MAPK) specific scaffold regulating nuclear export of influenza virus ribonucleoprotein complexes [0.03%]
宿主蛋白激酶Cα：新型有丝分裂激活的蛋白激酶（MAPK）支架，调控流感病毒核糖核蛋白复合物的核输出
Indrani Das Jana,Soumik Dey,Manoj Si et al.
Indrani Das Jana et al.
Host protein kinase C (PKC) isoforms are well known modulators of different steps of influenza virus replication cycle. PKC⍺ was reported to activate the Rapidly Accelerated Fibrosarcoma (Raf)/ Mitogen-activated protein kinase kinase (MEK)...
Ecological ubiquity and phylogeny drive nestedness in phages-bacteria networks and shape the bacterial defensome [0.03%]
生态广布性和系统发育驱动噬菌体-细菌网络的嵌套性并塑造细菌防御系统
Chloé Feltin,Sylvain Piry,Benoit Moury et al.
Chloé Feltin et al.
Identifying the ecological and evolutionary factors that shape phage-bacterial interactions is key to understanding their dynamics in microbial communities. Yet, such interactions remain poorly characterised in plant agroecosystems. Here, w...
Correction: Proximity labelling reveals VPS13C as a regulator of Salmonella-containing vacuole fission [0.03%]
订正：邻近标记发现VPS13C是萨门氏菌含有的囊泡分离的调节因子
Anna K Waldmann,Dustin A Ammendolia,Andrew M Sydor et al.
Anna K Waldmann et al.
[This corrects the article DOI: 10.1371/journal.ppat.1013507.]. Copyright: © 2025 Waldmann et al. This is an open access article distributed under the t...
Published Erratum
PLoS pathogens. 2025 Dec 30;21(12):e1013816. DOI:10.1371/journal.ppat.1013816 2025
A lignan compound regulates LPS modifications via PmrA/B signaling cascades to potentiate colistin efficacy in vivo [0.03%]
黄酮化合物通过PmrA/B信号通路调节LPS修饰以增强多粘菌素的体内疗效
Qiuyue Diao,Zixing Zhong,Qin Zhong et al.
Qiuyue Diao et al.
There has been a substantial gap between drying antibiotic pipeline and ongoing antibiotic resistance crisis, necessitating approaches to revitalize existing antimicrobials to meet unmet clinical demand for viable treatments. Herein, a lign...
Peter J Gwynne,Jeffery S Bourgeois,Aarya Pandit et al.
Peter J Gwynne et al.
Lyme disease is caused by the host-adapted spirochete Borrelia burgdorferi. With a genome of only 1.5 mbp, B. burgdorferi is dependent on metabolites scavenged from their vertebrate and invertebrate hosts for growth. These scavenged nutrien...
Large-particle aerosol exposure to the Bangladesh or Malaysia strain of Nipah virus results in markedly divergent disease presentation in African Green Monkeys [0.03%]
吸入不同毒株的尼帕病毒后绿猴产生不同的疾病表现形式
Yu Cong,Jeremy Bearss,Venkatesh Mani et al.
Yu Cong et al.
Nipah virus (NiV), a highly pathogenic zoonotic paramyxovirus, causes severe respiratory and neurological disease in humans, with a case-fatality rate around 60%. Descriptions of cases in the clinical setting suggest that the two primary li...