Provision of preferred nutrients to macrophages promotes Salmonella intracellular replication without relying on Type III secretion systems [0.03%]
向巨噬细胞供应优势营养素可促进沙门氏菌在胞内的复制且不依赖于III型分泌系统
Francisco-Javier Garcia-Rodriguez,Paula Martinez-Oca,Camila Valenzuela et al.
Francisco-Javier Garcia-Rodriguez et al.
Intracellular survival and replication within macrophages are key virulence determinants of Salmonella enterica serovar Typhimurium. This phenomenon is traditionally attributed to the activity of its two Type III Secretion Systems (T3SS) an...
Reduced inflammatory and Th1 transcriptional profiles in geriatric versus adult cotton rats infected with respiratory syncytial virus [0.03%]
老年棉鼠与成年棉鼠感染呼吸道合胞病毒后的减炎症和Th1转录特征分析研究报告
Jonathan Miller,Cameron Leedale,Ayse Selen Yilmaz et al.
Jonathan Miller et al.
Human respiratory syncytial virus (RSV) is a leading cause of severe respiratory disease in elderly populations. RSV clearance is delayed in individuals over 65 years of age, a finding that is recapitulated in the geriatric cotton rat model...
Characterisation of the thermal and non-thermal stress conditions that activate the Plasmodium falciparum AP2-HS-dependent heat-shock response [0.03%]
表征活化恶性疟原虫AP2-HS依赖型热休克反应的热应激和非热应激条件
Neus Ràfols,Prince B Nyarko,Marc Chillarón-Adán et al.
Neus Ràfols et al.
To preserve proteome homeostasis and survive at higher-than-optimal temperatures, organisms have evolved the conserved heat-shock (HS) response (HSR), characterised by increased expression of specific chaperone-encoding genes. In the human ...
Host-specific ubiquitination of prM orchestrates ESCRT recruitment to mediate efficient Japanese Encephalitis Virus assembly in vertebrates [0.03%]
宿主特异性prM泛素化通过募集ESCRT调控脊椎动物日本脑炎病毒高效装配
Chenxi Li,Wenzhuang Guo,Wen Zhao et al.
Chenxi Li et al.
Mosquito-borne orthoflavivirus, such as Japanese encephalitis virus (JEV), Dengue virus (DENV), and Zika virus (ZIKV), pose a serious global health threat. As obligate intracellular parasites, they often hijack the host ubiquitin system to ...
Sialic acids are a barrier to the entry of non-influenza orthomyxoviruses [0.03%]
唾液酸是非流感正粘病毒属病毒入侵的屏障
Gabriel Dupré,Jorge Moreno-García,Elias Bendl et al.
Gabriel Dupré et al.
Sialic acids (SAs) are abundantly expressed on vertebrate cell surfaces and are widely recognized as key viral attachment factors, particularly for influenza viruses. However, their role remains understudied in other orthomyxoviruses, such ...
A structure-based epitope tagging approach identifies vulnerable sites on the malarial P36-P52 protein complex for antibody-mediated neutralization of Plasmodium sporozoites [0.03%]
基于结构的表位标签方法鉴定出抗体介导马拉 Larval 疟原虫子孢子中和作用的脆弱部位
Samhita Das,Lien Boeykens,Manon Loubens et al.
Samhita Das et al.
Malaria is caused by apicomplexan parasites of the genus Plasmodium, which are transmitted through the bite of Anopheles mosquitoes that inject sporozoites (SPZs) into the skin. SPZs migrate to and infect the liver for an initial round of r...
Independent proviral and antiviral host factors recognize the same capsid protein in divergent human herpesviruses [0.03%]
独立的脯病毒和抗病毒宿主因素识别高度分化的人类疱疹病毒的同一衣壳蛋白
Yiqi Zhao,Sarah Probert,Jan Birkel et al.
Yiqi Zhao et al.
Intrinsic cellular factors that inhibit herpesvirus infection remain incompletely defined. Here, we identify TRIM5α as a restriction factor for herpes simplex virus type 1 (HSV-1). TRIM5α-mediated restriction requires its ubiquitin ligase...
Novel duck reovirus σC hijacks the mitochondrial COQ6-CoQ10 axis to drive NLRP3-dependent pyroptosis [0.03%]
新型鸭重组病毒σC劫持线粒体COQ6-CoQ10轴以驱动NLRP3依赖的细胞焦亡
Hui Yan,Lei Bei,Mingrui Zhao et al.
Hui Yan et al.
Mitochondrial metabolic homeostasis serves as a critical checkpoint that integrates cellular bioenergetics with innate immunity. While viruses often subvert mitochondrial functions to manipulate cell fate, the specific viral determinants th...
Shiga toxin delivery in extracellular vesicles induces high mortality and severe kidney injury in a Gb3-dependent manner [0.03%]
葡萄糖脑苷脂依赖性分泌颗粒中的志贺毒素诱导高死亡率和严重肾损伤
Markus Wendler,Alexandra Gerogianni,Johan Rebetz et al.
Markus Wendler et al.
Escherichia coli O157:H7 is a non-invasive Shiga toxin (Stx)-producing pathogen that causes gastroenteritis and hemolytic uremic syndrome characterized by acute kidney injury. Stx binding to cells induces release of extracellular vesicles (...
G protein-coupled receptor SmGPCR9 interacts with neuropeptides and controls spermatogenesis in Schistosoma mansoni [0.03%]
血吸虫SmGPCR9受体与神经肽相互作用并调控其精细胞发生发育
Saranya Geetha,Simone Haeberlein,Steffen Hahnel et al.
Saranya Geetha et al.
Schistosomiasis is a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma, impacting hundreds of millions of people and animals globally. Disease pathology primarily originates from host immune responses to para...