Lumpy skin disease virus protein LSDV122 impairs IFN-I receptor complex formation to evade host innate immunity [0.03%]
非洲牛痘病毒蛋白LSDV122通过干扰I型干扰素受体复合物的形成来逃避宿主先天免疫反应
Meng-Yao Sun,Li-Bo Cao,Qin-Ling Wan et al.
Meng-Yao Sun et al.
Lumpy skin disease virus (LSDV) is a pathogenic poxvirus that causes systemic disease in cattle. Although LSDV encodes multiple proteins that are predicted to regulate host defense, the underlying mechanisms of its immune evasion strategies...
Oligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions [0.03%]
泛素转移酶(OTST)复合物抑制有效治疗啮齿动物和人类的异常朊蛋白病理沉积
Kathryn S Beauchemin,Judit Kun,Bradley Groveman et al.
Kathryn S Beauchemin et al.
Prion diseases are invariably fatal neurodegenerative diseases that occur when the prion protein misfolds into a pathogenic form. There are currently no clinical treatments or cures for prion disease. Current challenges in the development o...
Inapparent maternal ZIKV infection impacts fetal brain development and postnatal behavior [0.03%]
隐性母体寨卡病毒感染影响胎儿脑发育和产后行为
Tsui-Wen Chou,Micheal McCourt,Eduard Marmut et al.
Tsui-Wen Chou et al.
Zika virus (ZIKV) has emerged as a significant public health concern due to its association with severe neurological outcomes in infants, including microcephaly and congenital Zika syndrome (CZS). However, while the majority of ZIKV infecti...
Exonuclease ISG20 inhibits human cytomegalovirus replication by inducing an innate immune defense signature [0.03%]
exonuclease ISG20通过诱导固有免疫防御信号抑制人巨细胞病毒的复制
Matthias Hehl,Myriam Scherer,Cora Stegmann et al.
Matthias Hehl et al.
ISG20 is an interferon-regulated protein that exhibits RNase activity thereby inhibiting the replication of a broad spectrum of RNA viruses. By single cell RNA sequencing, we identified ISG20 as an antiviral factor for human cytomegalovirus...
Serine protease-driven entry and S2' cleavage flexibility of feline coronavirus during feline enterocyte infections [0.03%]
猫冠状病毒在感染猫肠上皮细胞过程中由丝氨酸蛋白酶介导的侵入和S2′位点裂解的灵活性
Bixia Chen,Luna Vanden Buijs,Nathalie Vanderheijden et al.
Bixia Chen et al.
Coronaviruses not only hijack host cells to serve as viral factories but also exploit host proteolytic systems to activate their spike (S) protein, the key glycoprotein mediating receptor binding and membrane fusion. Feline coronavirus (FCo...
Arginine metabolism has a pivotal function for the encystation of Giardia duodenalis [0.03%]
精氨酸代谢在十二指肠毛滴虫包囊化过程中发挥重要作用
Christian Klotz,Ricarda Leisering,Kari D Hagen et al.
Christian Klotz et al.
Arginine metabolism plays a key role in the energy metabolism of the intestinal parasite Giardia duodenalis, an amitochondrial protozoan that infects humans and animals and causes significant morbidity. Despite that an arginine deiminase (A...
Monoclonal neutralizing antibodies elicited by infection with Kaposi sarcoma-associated herpesvirus reveal critical sites of vulnerability on gH/gL [0.03%]
卡波西肉瘤相关疱疹病毒感染诱导的单克隆中和抗体揭示了gH/gL上的关键脆弱位点
Yu-Hsin Wan,Sara Pernikoff,Nicholas T Aldridge et al.
Yu-Hsin Wan et al.
Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic virus that causes Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease. A vaccine that prevents KSHV infection or serves in the treatment of KSHV-related d...
cGAS-STING dependent type I IFN reduces Leptospira interrogans renal colonization in mice [0.03%]
cGAS-STING依赖的I型IFN降低小鼠肾内的钩端螺旋体定植
Suman Gupta,James Matsunaga,Bridget Ratitong et al.
Suman Gupta et al.
Leptospira interrogans is the major causative agent of leptospirosis. Humans, canines and agricultural animals are susceptible to Leptospira species and can develop fulminant disease. Rodents serve as reservoir hosts in which the bacteria c...
Evaluating modes of influenza transmission (EMIT-2): Insights from lack of transmission in a controlled transmission trial with naturally infected donors [0.03%]
评估流感传播方式（EMIT-2）：自然感染供体受控传播试验未能成功传播的启示
Jianyu Lai,Hamed Sobhani,Kristen K Coleman et al.
Jianyu Lai et al.
A previous controlled human influenza transmission trial produced minimal transmission using nasal inoculation of an egg adapted virus. Therefore, we implemented a new trial with naturally infected Donors. We recruited healthy Recipients fo...
EnP1 exploits H2Aub-dependent epigenetic reprogramming to promote microsporidia proliferation in host cells [0.03%]
恩佩尔1利用H2Aub依赖性表观遗传重编程促进孢子虫在宿主细胞内的增殖
Jingyu Guan,Yongliang Wang,Ming Fu et al.
Jingyu Guan et al.
Microsporidia, as opportunistic parasitic pathogens, constitute a formidable threat to human health. Although the regulatory circuitry of the nucleus-targeted effector EnP1 remains highly intricate and only partially characterized, our stud...