Pervasive HIV recombination limits the utility of circulating recombinant form nomenclature [0.03%]
普遍存在的HIV重组限制了循环重组形式命名法的实用性
Heather E Grant,Abayomi S Olabode,Dorothea Seiler Vellame et al.
Heather E Grant et al.
The naming of HIV-1 circulating recombinant forms (CRFs)-descendent viruses from the same intersubtype recombination events, is along with the designation of 'subtypes' and 'groups', routinely used to track HIV-1 diversity. However, we argu...
Quantification and localization of integrated HIV-1 in memory and naïve CD4+ T cells from adolescents and young adults with perinatally-acquired HIV-1 [0.03%]
青少年和年轻成人获得性人类免疫缺陷病毒（HIV-1）整合量及定位定量及HIV-1记忆和初始CD4+t细胞的定位
Adit Dhummakupt,Alexander G McFarland,Joseph Szewczyk et al.
Adit Dhummakupt et al.
HIV-1 establishes latency in resting memory CD4+ T cells, creating a long-lived reservoir that poses a barrier to HIV-1 cure. This reservoir is thought to form by initial infection of antigen-activated CD4+ T-cells that then transition into...
Editorial Note: The role of 9-O-acetylated glycan receptor moieties in the typhoid toxin binding and intoxication [0.03%]
编者按：伤寒毒素结合和中毒中的9-O-乙酰化糖受体的作用
PLOS Pathogens Editors
PLOS Pathogens Editors
Characterization of an immunocompetent, young adult mouse model for studying chikungunya virus neuroinvasion and central nervous system infection [0.03%]
一种免疫健全的小鼠模型用于研究登迦病毒的神经侵袭及其中枢神经系统感染特征分析
Alyssa M Lantz,Freedom M Green,Amanda J Cowan et al.
Alyssa M Lantz et al.
The arthropod-borne chikungunya virus poses a re-emerging global health threat, causing millions of cases worldwide. Neurological complications induced by chikungunya virus are being increasingly reported in vulnerable populations, includin...
TANK potentiates antiviral innate immunity by recruiting deubiquitinase USP46 to activate IKKε [0.03%]
由TANK通过募集去泛素酶USP46活化IKKε而增强的抗病毒天然免疫能力
Zhenghao Li,Can Yang,Juanjuan Shu et al.
Zhenghao Li et al.
IKKε plays an important role in interferon (IFN) production, however, its regulation remains poorly understood. In this study, we demonstrate that black carp TANK (bcTANK) interacts with bcIKKε and significantly enhances its activation of...
HIV capsid inhibitors: Mechanisms, resistance, and therapeutic advances [0.03%]
HIV衣壳抑制剂：机制、耐药性和治疗进展
Mohamed Mahdi,Botond Lakatos,János András Mótyán et al.
Mohamed Mahdi et al.
The capsid (CA) of the human immunodeficiency virus (HIV) has emerged as a critical therapeutic target owing to its essential roles in viral replication, nuclear import, and integration. Capsid inhibitors (CIs) disrupt these processes by bi...
STING agonist protects against exacerbation of schistosome egg-induced immunopathology [0.03%]
STING激动剂能够预防并加重血吸虫虫卵诱导的免疫病理损伤
Pengyu Liu,Megan S Linnane,Kaile Jump et al.
Pengyu Liu et al.
Schistosomiasis, caused by parasitic worms, affects over 250 million people globally, with limited treatment options due to praziquantel's inability to prevent reinfection or reduce immunopathology. In Schistosoma mansoni (S. mansoni) infec...
Defense against parasites covaries with reproductive timing, not with resistance [0.03%]
防御寄生虫的能力与繁殖时间相关，而非抵抗力大小有关
Amanda Kyle Gibson,Linyao Peng,Tessa E Batterton et al.
Amanda Kyle Gibson et al.
Defense is the ability of a host to minimize fitness loss to parasites. It is among the most variable phenotypes in host populations, and this variation facilitates rapid adaptation under parasite-mediated selection. We do not, however, kno...
N-linked glycosylation of NS1 protein modulates progeny virion assembly in orthoflaviviruses [0.03%]
N连接型糖基化NS1蛋白可调节正链黄病毒后代病毒装配
Senzhao Zhang,Xuedan Tang,Zhen Wu et al.
Senzhao Zhang et al.
Tembusu virus (TMUV) is a mosquito-borne avian virus belonging to the genus Orthoflavivirus within the family Flaviviridae. The nonstructural protein 1 (NS1) of TMUV is a secretory protein containing three N-linked glycosylation sites at re...
Glycoprotein G enables HSV-2 neuroinvasion and provides protection as a glycosylated vaccine antigen [0.03%]
糖蛋白G使HSV-2侵入神经并作为糖基化疫苗抗原提供保护作用
Ebba Könighofer,Carolina Gustafsson,Lindvi Gudmundsdotter et al.
Ebba Könighofer et al.
The role of glycoprotein G (gG-2) of herpes simplex virus type 2 (HSV-2) in viral pathogenesis remains poorly understood. gG-2 is cleaved into a secreted form (sgG-2) and a membrane-associated form (mgG-2), but the in vivo function of mgG-2...