Metabolic reprogramming tips vaccinia virus infection outcomes by stabilizing interferon-γ induced IRF1 [0.03%]
代谢重组通过稳定干扰素-γ诱导的IRF1来改变天花病毒感染的结果
Tyron Chang,Jessica Alvarez,Sruthi Chappidi et al.
Tyron Chang et al.
Interferon (IFN) induced activities are critical, early determinants of immune responses and infection outcomes. A key facet of IFN responses is the upregulation of hundreds of mRNAs termed interferon-stimulated genes (ISGs) that activate i...
A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants [0.03%]
一类新型的4-氨基喹啉类化学型具有多阶段抗疟活性和无耐药性交叉抵抗力与PfCRT和PfMDR1突变体的特点
Letícia Tiburcio Ferreira,Gustavo Capatti Cassiano,Luis Carlos Salazar Alvarez et al.
Letícia Tiburcio Ferreira et al.
Artemisinin-based combination therapy (ACT) is the mainstay of effective treatment of Plasmodium falciparum malaria. However, the long-term utility of ACTs is imperiled by widespread partial artemisinin resistance in Southeast Asia and its ...
BiP/GRP78 is a pro-viral factor for diverse dsDNA viruses that promotes the survival and proliferation of cells upon KSHV infection [0.03%]
双链DNA病毒的促病毒因子BiP/GRP78在KSHV感染后促进细胞存活和增殖
Guillermo Najarro,Kevin Brackett,Hunter Woosley et al.
Guillermo Najarro et al.
The Endoplasmic Reticulum (ER)-resident HSP70 chaperone BiP (HSPA5) plays a crucial role in maintaining and restoring protein folding homeostasis in the ER. BiP's function is often dysregulated in cancer and virus-infected cells, conferring...
The protein segregase VCP/p97 promotes host antifungal defense via regulation of SYK activation [0.03%]
蛋白质分离酶VCP/p97通过调节SYK活化促进宿主抗真菌防御作用
Zhugui Shao,Li Wang,Limin Cao et al.
Zhugui Shao et al.
C-type lectin receptors (CLRs) are essential to execute host defense against fungal infection. Nevertheless, a comprehensive understanding of the molecular underpinnings of CLR signaling remains a work in progress. Here, we searched for yet...
Delineating the functional activity of antibodies with cross-reactivity to SARS-CoV-2, SARS-CoV-1 and related sarbecoviruses [0.03%]
表征针对SARS-CoV-2、SARS-CoV-1及相关sarbecovirus具有交叉反应的抗体的功能活性
Felicitas Ruiz,William B Foreman,Michelle Lilly et al.
Felicitas Ruiz et al.
The recurring spillover of pathogenic coronaviruses and demonstrated capacity of sarbecoviruses, such SARS-CoV-2, to rapidly evolve in humans underscores the need to better understand immune responses to this virus family. For this purpose,...
Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the autophagic degradation of adaptor protein SH3KBP1 to antagonize host innate immune responses by enhancing K63-linked polyubiquitination of RIG-I [0.03%]
猪生殖与呼吸综合症病毒非结构蛋白2通过促进RIG-I的K63连接多泛素化增强宿主天然免疫反应拮抗蛋白SH3KBP1的自噬降解
Jiaoyang Li,Jing Zhang,Pu Sun et al.
Jiaoyang Li et al.
Non-structural protein 2 (NSP2) of PRRSV is highly variable and plays crucial roles in the virus's life cycle. To elucidate the function of NSP2 during PRRSV infection, we identified SH3KBP1 as an NSP2-interacting host protein using mass sp...
Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens [0.03%]
针对疟原虫裂殖体抗原和变异表面抗原的长寿记忆B细胞表型差异
Raphael A Reyes,Louise Turner,Isaac Ssewanyana et al.
Raphael A Reyes et al.
Plasmodium falciparum infections elicit strong humoral immune responses to two main groups of antigens expressed by blood-stage parasites: merozoite antigens that are involved in the erythrocyte invasion process and variant surface antigens...
Potent broadly neutralizing antibodies mediate efficient antibody-dependent phagocytosis of HIV-infected cells [0.03%]
高效抗体依赖的巨噬细胞吞噬作用清除艾滋病病毒感染细胞
Brian J Snow,Nida K Keles,Michael W Grunst et al.
Brian J Snow et al.
Antibody-dependent cellular phagocytosis (ADCP) has been implicated in protection against HIV-1. However, methods for measuring ADCP currently rely on the phagocytosis of gp120- or gp41-coated beads that do not reflect physiologically relev...
Balancing acts: The posttranslational modification tightrope of flavivirus replication [0.03%]
走钢丝般的平衡术：黄病毒复制的翻译后修饰精妙调控
RuthMabel Boytz,Maudry Laurent-Rolle
RuthMabel Boytz
Posttranslational modifications (PTMs) such as phosphorylation, ubiquitination, SUMOylation, and ISGylation are involved in various cellular pathways, including innate immunity and disease processes. Many viruses have developed sophisticate...
The full transcription map of cottontail rabbit papillomavirus in tumor tissues [0.03%]
棉尾兔乳头瘤病毒在肿瘤组织中的完整转录图谱
Pengfei Jiang,Vladimir Majerciak,Jiafen Hu et al.
Pengfei Jiang et al.
Cottontail rabbit papillomavirus (CRPV), the first papillomavirus associated with tumor development, has been used as a powerful model to study papillomavirus pathogenesis for more than 90 years. However, lack of a comprehensive analysis of...