Tibetan PHD2D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIFα:IFN axis [0.03%]
缺氧条件下西藏人PHD2D4E;C127S基因变异体通过HIFα：干扰素轴抵抗病毒感染，但在正常氧浓度下会增加感染倾向
Riya Ghosh,Garima Joshi,Nishith M Shrimali et al.
Riya Ghosh et al.
We previously reported that Tibetan-specific variant of prolyl-hydroxylase-2 (PHD2)D4E;C127S protects highlanders from hypoxia-triggered pathologies by destabilizing hypoxia-inducible factor (HIF)-1α. Others have reported that stabilized H...
Polysaccharide synthesis operon modulates Rickettsia-endothelial cell interactions [0.03%]
多糖合成操纵子调节立克次氏体-内皮细胞相互作用
Smruti Mishra,Luke Helminiak,Hwan Keun Kim
Smruti Mishra
Pathogenic Rickettsia species target vascular endothelial cells and cause systemic vasculitis. As obligate intracellular bacterial pathogens, Rickettsia must secure nutritional resources within the cytoplasm of endothelial cells while simul...
IRF6 controls Epstein-Barr virus (EBV) lytic reactivation and differentiation in EBV-infected epithelial cells [0.03%]
IRF6控制Epstein-Barr病毒（EBV）在EBV感染的上皮细胞中的再活化和分化
Stuart A Fogarty,Deo R Singh,Scott E Nelson et al.
Stuart A Fogarty et al.
Latent Epstein-Barr virus (EBV) infection promotes undifferentiated nasopharyngeal carcinoma (NPC) and gastric carcinoma (GC), while EBV infection of normal differentiated oropharyngeal epithelial cells is lytic and kills the cell. Establis...
A comprehensive phylogeny of mammalian PRNP gene reveals no influence of prion misfolding propensity on the evolution of this gene [0.03%]
哺乳动物PRNP基因的全面系统发育分析未发现朊蛋白错误折叠倾向对这一基因进化的影响
Cristina Sampedro-Torres-Quevedo,Hasier Eraña,Jorge M Charco et al.
Cristina Sampedro-Torres-Quevedo et al.
Prion diseases are invariably fatal neurodegenerative diseases that affect some mammalian species, including humans. These diseases are caused by the misfolding of the cellular prion protein (PrPC) into a pathologic isoform (PrPSc). The pri...
Direct and indirect pathways linking the Lon protease to motility behaviors in the pathogen Pseudomonas aeruginosa [0.03%]
铜绿假单胞菌中Lon蛋白酶与运动性行为之间的直接和间接联系路径
Aswathy Kallazhi,Anamika Rahman,Ute Römling et al.
Aswathy Kallazhi et al.
The ATP-dependent cytoplasmic protease Lon has critical functions in protein quality control and cellular regulation in organisms across the three domains of life. In the opportunistic pathogen Pseudomonas aeruginosa, lon loss-of-function m...
Infectome analysis of bat kidneys from Yunnan province, China, reveals novel henipaviruses related to Hendra and Nipah viruses and prevalent bacterial and eukaryotic microbes [0.03%]
云南省蝙蝠肾脏感染组分析发现与亨德拉和尼帕病毒相关的新型 henipavirus 以及广泛存在的细菌和真核微生物
Guopeng Kuang,Tian Yang,Weihong Yang et al.
Guopeng Kuang et al.
Bats are natural reservoirs for a wide range of microorganisms, including many notable zoonotic pathogens. However, the composition of the infectome (i.e., the collection of viral, bacterial and eukaryotic microorganisms) within bat kidneys...
The structural features and immunological role of biomphalysins in the snail Biomphalaria glabrata [0.03%]
椎实螺Biomphalaria glabrata中生物基质蛋白的结构特征及其免疫学作用
Pierre Poteaux,Aline Parpinel,Chantal Ripoll et al.
Pierre Poteaux et al.
Biomphalysins are β-Pore Forming Toxins (β-PFT) identified in the planorbid Biomphalaria glabrata that belong to the aerolysin-like protein family. Despite potentially diverse biochemical activities, very few eukaryotic aerolysin-related ...
Enterococcal cell wall remodelling underpins pathogenesis via the release of the Enteroccocal Polysaccharide Antigen (EPA) [0.03%]
肠球菌细胞壁重塑通过释放肠球菌多糖抗原(EPA)来促进其致病性
Robert E Smith,Bartosz J Michno,Rene L Christena et al.
Robert E Smith et al.
Enterococci are opportunistic pathogens displaying a characteristic ovoid shape, typically forming pairs of cells (diplococci) and short chains. Control of cell chain length in Enterococcus faecalis relies on the activity of the major N-ace...
Distinct neutralization sensitivity between adult and infant transmitted/founder HIV-1 subtype C viruses to broadly neutralizing monoclonal antibodies [0.03%]
成人和婴儿传播/创始型HIV-1型C病毒对广谱中和单克隆抗体的敏感性不同
Bongiwe Ndlovu,Kamini Gounder,Nelisiwe Zikhali et al.
Bongiwe Ndlovu et al.
Broadly neutralizing antibodies (bnAbs), passively administered or elicited through vaccination, are a promising strategy for novel HIV prevention, treatment or inducing ART-free remission. However, HIV diversity and evolution are a barrier...
Jianfeng Lin,Scott G Filler
Jianfeng Lin
Candida albicans is a normal constituent of the human microbiota and a ubiquitous human threat. This fungus causes diseases ranging from superficial cutaneous and mucosal candidiasis to life-threatening disseminated candidiasis. C. albicans...