Peptidoglycan architecture dictates protein interactions, tissue tropism, and arthritis in the Lyme disease spirochete Borrelia burgdorferi [0.03%]
肽聚糖结构决定了莱姆病螺旋体的蛋白相互作用、组织趋向性和关节炎特性
Saadman S Ahmad,Osamudiamen Ebohon,Mecaila E McClune et al.
Saadman S Ahmad et al.
Lyme disease is a vector-borne illness transmitted by infected Ixodes spp. ticks. Dissemination of the Lyme spirochete-Borrelia burgdorferi-from the tick bite site results in a bi-phasic infection; the latter phase can cause severe musculos...
Multifaceted B cell response to transient HIV viremia in elite controllers [0.03%]
精英型控制者一过性HIV病毒血症引起的多面性的B细胞反应
Luke Muir,Ondrej Suchanek,Peter Thomas et al.
Luke Muir et al.
Chronic HIV infection drives B cell dysfunction associated with the accumulation of tissue-like memory (TLMs) and activated memory B cells (MBCs) but decline in resting memory B cells. TLMs express multiple inhibitory receptors and lack res...
Plant rhabdovirus glycoprotein activates unfolded protein response-mediated antiviral ER-phagy in insect vectors [0.03%]
植物鱼春病毒糖蛋白激活昆虫载体中的unfolded蛋白质反应介导的抗病毒内质网自噬
Siyu Chen,Yu Cheng,Yupeng Tang et al.
Siyu Chen et al.
Although viral infection-induced endoplasmic reticulum autophagy (ER-phagy) is well characterized in mammalian systems, the mechanisms underlying arbovirus-triggered ER-phagy in insect vectors remain poorly understood. This study demonstrat...
Structural mapping of NTCP distinguishes its dual functionality as a hepatitis B virus receptor and bile acid transporter [0.03%]
NTCP的结构mapping区分了其作为乙型肝炎病毒受体和胆汁酸转运蛋白的双重功能
Kayo Matsuzawa,Toru Ekimoto,Chisa Kobayashi et al.
Kayo Matsuzawa et al.
Sodium taurocholate cotransporting polypeptide (NTCP) is a hepatic transmembrane (TM) protein that functions both as a bile acid transporter and as a host receptor for hepatitis B and D viruses via the viral preS1 binding. The structural an...
Structure of defense against restriction proteins DarA and Hdf in phage P1 reveals a new molecular mechanism during phage assembly, infection and DNA ejection [0.03%]
噬菌体P1抗限制性蛋白DarA和Hdf的防御结构揭示了噬菌体装配、感染及DNA释放过程中的一种新的分子机制
Jing Zheng,Yuan Chen,Siting Chen et al.
Jing Zheng et al.
The continuous "arms race" between bacterial antiviral defense systems and phage anti-defense strategies drives evolutionary innovation. Previous study indicated that the defense against restriction (Dar) proteins DarA and Hdf in myophage P...
Carbapenem resistant Klebsiella pneumoniae isolates at a tertiary hospital in Cape Town, South Africa, are dominated by specific local clones rather than previously described international lineages [0.03%]
南非开普敦一家三级医院的碳青霉烯耐药肺炎克雷伯菌分离株以特定的地方谱系为主，而不是之前描述的国际谱系主导
Kedišaletše Moloto,Mae Newton-Foot,Angela Dramowski et al.
Kedišaletše Moloto et al.
Carbapenem-resistant K. pneumoniae (CRKP) are increasingly prevalent pathogens in hospital settings worldwide. In early 2019, an outbreak of carbapenem-resistant Enterobacterales (CRE) at a tertiary hospital in South Africa triggered a retr...
Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity [0.03%]
与年龄相关的新冠病毒肺炎严重程度的肺浸润病毒特异性T细胞的动力学研究
Rise Kurokawa,Chatherine Silas Mtali,Innocent John Daniel et al.
Rise Kurokawa et al.
Coronavirus disease 2019 (COVID-19) pneumonia is prevalent in the elderly infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, the mechanisms underlying its age-dependent pathogenesis remain unclear. In this ...
HIV-1 derived oligonucleotides induce a type I IFN/STING dependent immune suppression reversible by targeting IFNARI [0.03%]
HIV-1衍生寡核苷酸通过诱导I型干扰素依赖的免疫抑制作用发挥抗病毒作用且该过程可通过靶向IFNAR1逆转
Cecilia Svanberg,Ravi Prasad Mukku,Sabri O Besler et al.
Cecilia Svanberg et al.
The hallmark of HIV-1 (HIV) infection is the progressive development of multicellular and systemic immune dysfunction, culminating in AIDS. Dendritic cells (DCs) play a pivotal role in HIV dissemination to CD4 + T cells, which are subsequen...
Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypes [0.03%]
HIV SMRTcap技术的开发与验证及其在不同组织和亚型HIV-1储存库特征分析中的应用
Ghazal Sadri,Steven T Nadakal,William Lauer et al.
Ghazal Sadri et al.
Human Immunodeficiency Virus type 1 (HIV-1) is responsible for the global HIV/AIDS epidemic and the establishment of an integrated HIV-1 reservoir remains the primary obstacle to cure. Upon therapy interruption, reactivation of the persiste...
Basal IFNλ2/3 signaling is required for ISG expression and viral control in human intestinal epithelial cells [0.03%]
人肠上皮细胞中ISG表达和抗病毒作用需要基础的IFNλ2/3信号转导路径
Yagmur Keser,Zehra Sena Bumin,Amelia Perez Valiente et al.
Yagmur Keser et al.
Interferon-lambdas (IFNλs) serve as critical mediators of antiviral defense at mucosal surfaces. Beyond their established role in regulating innate immune responses during infection, recent evidence demonstrates that IFNλs are constitutiv...