Rasputin/G3BP mediates subversion of antiviral immunity by o'nyong-nyong virus in Anopheles coluzzii [0.03%]
O'nyong-nyong病毒通过Rasputin/G3BP介导的机制破坏非洲疟蚊的抗病毒免疫反应
Solène Cottis,Adrien A Blisnick,Emma Brito-Fravallo et al.
Solène Cottis et al.
Cellular G3BP proteins are essential for alphavirus infection in both vertebrate and mosquito hosts, but the underlying mechanism of their proviral activity is poorly understood in any host. Whether the mosquito G3BP ortholog, Rasputin (Rin...
Unveiling a missing component of the atypical type IV secretion system required for natural transformation of Helicobacter pylori [0.03%]
解开幽门螺旋杆菌自然转化所需的非常规型IV型分泌系统缺失组件
J Francisco Villa,Sumedha Kondekar,Yoann Fauconnet et al.
J Francisco Villa et al.
Exchange of genetic information by natural transformation shapes bacterial evolution. In Helicobacter pylori it is thought to drive its unusually high recombination rate, which has a crucial role in the evolution of virulence and the propag...
Macrophage-mediated antibiotic evasion and competitive dominance of mcr-3-carrying Escherichia coli [0.03%]
巨噬细胞介导的携带mcr-3基因的大肠埃希氏菌抗生素逃避和竞争优势机制
Shuyu Tan,Wenjuan Yin,Jian Sun et al.
Shuyu Tan et al.
Mobile colistin resistance (mcr) genes compromise the efficacy of last-resort polymyxin antibiotics. Notably, the global prevalence of mcr-3 has continued to increase despite reductions in colistin use, suggesting that selective forces beyo...
A mouse model of Zika virus sexual transmission reveals a limited transmission window shorter than viral RNA persistence in semen [0.03%]
寨卡病毒的性传播小鼠模型揭示了一个有限的传播窗口期，该窗口比精液中病毒RNA持续时间短
Jia-Tong Chang,Zhan-Zhan Bian,Lin-Shen-Yang Liu et al.
Jia-Tong Chang et al.
Sexual transmission of Zika virus (ZIKV) presents a distinct public health challenge, yet its kinetics and mechanisms remain poorly defined due to the lack of suitable immunocompetent animal models. Here, we established a mouse model of ZIK...
Biofilm-derived curli and Z-DNA shape anti-DNA antibody responses during Salmonella infections [0.03%]
沙门氏菌感染期间，生物膜衍生的curli和Z-DNA塑造抗DNA抗体反应
Molly Elkins,Kaitlyn Grando,Courtney Covolo et al.
Molly Elkins et al.
Antibodies to Z-DNA, a non-canonical DNA conformation with a left-handed zigzag backbone, are abundant in the serum of patients with systemic lupus erythematosus (SLE), with levels increasing with disease activity and flares. As SLE is asso...
Acinetobacter baumannii lipooligosaccharide core region promotes CD14-dependent TLR4 endocytosis and enhances pathogenicity through interferon-β production [0.03%]
baumannii脂寡糖核心结构通过促进CD14依赖的TLR4内吞增强干扰素-β产生并提高其致病性
Yi-Tzu Lee,Te-Li Chen,Shu-Chen Kuo et al.
Yi-Tzu Lee et al.
Bacterial strains harboring lipooligosaccharides (LOS) with a core region are more pathogenic than those without it; however, the underlying mechanism remains to be fully elucidated. Lipid A has been believed to be the primary moiety of LOS...
Co-regulation of HIV control and cytomegalovirus pp65-specific IL-1β and TNF-α responses by genetic variants in the MHC region [0.03%]
人类白细胞抗原区域的遗传变异体对HIV控制和巨细胞病毒pp65特异性IL-1β和TNF-α反应的共调节作用
Suzanne D E Ruijten,Jéssica C Dos Santos,Victoria Rios-Vazquez et al.
Suzanne D E Ruijten et al.
The spontaneous control of HIV infection in the absence of antiretroviral therapy, termed HIV control, is associated with genetic variation in the Major Histocompatibility Complex (MHC) locus. These variants are known to influence the immun...
Structural basis of a conserved, broad antigenic region surrounding the five-fold axis of foot-and-mouth disease virus revealed by swine neutralizing antibodies [0.03%]
猪抗体重链对接复合物的结构揭示了口蹄疫病毒五重轴周围保守的广谱表位区域
Qiongqiong Zhao,Shanquan Wu,Fengjuan Li et al.
Qiongqiong Zhao et al.
Foot-and-mouth disease virus (FMDV) exhibits extensive antigenic diversity and limited cross-protection among different serotypes, making the identification of broadly neutralizing antibodies (bnAbs) critical for the development of vaccines...
Two folds, many faces: The Magnaporthe oryzae MAX effector AVR-Pia targets novel rice HMA domain-containing proteins [0.03%]
两个功能，多样面貌：稻瘟菌效应蛋白AVR-Pia靶向水稻新型HMA结构域含蛋白质
Josephine H R Maidment,Svenja C Saile,Aurélien Bocquet et al.
Josephine H R Maidment et al.
Phytopathogenic fungi secrete effector proteins to promote virulence. The MAX (Magnaporthe Avrs and ToxB-like) effectors form a structurally conserved family despite significant sequence diversity. AVR-Pia, a MAX effector from the rice blas...
Structural requirements of blood factors binding to soluble hexon trimers with implications for adenovirus cell targeting and immune evasion [0.03%]
与可溶性六聚体结合的血液因子的结构要求及其对腺病毒细胞靶向和免疫逃避的影响
Olivia X Ma,Shao-Chia Lu,Haley E Mudrick et al.
Olivia X Ma et al.
Human adenovirus serotype 5 (HAdV-C5) is widely used as a gene delivery vector in both experimental and clinical settings. Upon intravenous administration, HAdV-C5 exhibits strong liver tropism, largely mediated by interactions between its ...