Challenging a paradigm: Staggered versus single-pulse mass dog vaccination strategy for rabies elimination [0.03%]
挑战传统观念：用于消灭狂犬病的分步与单次脉冲式群体犬类接种策略孰优孰劣
Brinkley Raynor Bellotti,Elvis W Díaz,Micaela De la Puente-León et al.
Brinkley Raynor Bellotti et al.
Background: From smallpox to poliomyelitis, halting contagion transmission through simultaneous mass vaccination is ubiquitous and often perceived as the only possible solution. But implementing mass vaccination campaigns...
Rodrigo Osuna-Orozco,Edward Castillo,Kameron Decker Harris et al.
Rodrigo Osuna-Orozco et al.
Large-scale recordings of neural activity over broad anatomical areas with high spatial and temporal resolution are increasingly common in modern experimental neuroscience. Recently, recurrent switching dynamical systems have been used to t...
A SuperLearner-based pipeline for the development of DNA methylation-derived predictors of phenotypic traits [0.03%]
基于SuperLearner的表观遗传学标志物预测性状的机器学习管道
Dennis Khodasevich,Nina Holland,Lars van der Laan et al.
Dennis Khodasevich et al.
Background: DNA methylation (DNAm) provides a window to characterize the impacts of environmental exposures and the biological aging process. Epigenetic clocks are often trained on DNAm using penalized regression of CpG s...
Structural prediction of chimeric immunogen candidates to elicit targeted antibodies against betacoronaviruses [0.03%]
针对β冠状病毒诱发定向抗体的嵌合免疫原结构预测候选对象
Jamel Simpson,Peter M Kasson
Jamel Simpson
Betacoronaviruses pose an ongoing pandemic threat. Antigenic evolution of the SARS-CoV-2 virus has shown that much of the spontaneous antibody response is narrowly focused rather than broadly neutralizing against even SARS-CoV-2 variants, l...
Contributions of action potentials to scalp EEG: Theory and biophysical simulations [0.03%]
动作电位对脑电图的贡献：理论与生物物理模拟
Niklas Brake,Anmar Khadra
Niklas Brake
Differences in the apparent 1/f component of neural power spectra require correction depending on the underlying neural mechanisms, which remain incompletely understood. Past studies suggest that neuronal spiking produces broadband signals ...
Interpreting the CTCF-mediated sequence grammar of genome folding with AkitaV2 [0.03%]
用AkitaV2解释CTCF介导的基因组折叠序列规则
Paulina N Smaruj,Fahad Kamulegeya,David R Kelley et al.
Paulina N Smaruj et al.
Interphase mammalian genomes are folded in 3D with complex locus-specific patterns that impact gene regulation. CTCF (CCCTC-binding factor) is a key architectural protein that binds specific DNA sites, halts cohesin-mediated loop extrusion,...
Jacopo Marchi,Chau Nguyen Ngoc Minh,Laurent Debarbieux et al.
Jacopo Marchi et al.
Bacteriophage (or 'phage' - viruses that infect and kill bacteria) are increasingly considered as a therapeutic alternative to treat antibiotic-resistant bacterial infections. However, bacteria can evolve resistance to phage, presenting a s...
Simulation-based validation of a method to detect changes in SARS-CoV-2 reinfection risk [0.03%]
基于模拟的验证SARS-CoV-2再感染风险变化检测方法的方法学文章
Belinda Lombard,Harry Moultrie,Juliet R C Pulliam et al.
Belinda Lombard et al.
Given the high global seroprevalence of SARS-CoV-2, understanding the risk of reinfection has become increasingly important. Models developed to track trends in reinfection risk should be robust against possible biases arising from imperfec...
RSero: A user-friendly R package to reconstruct pathogen circulation history from seroprevalence studies [0.03%]
RSero：一个用于从血清流行率研究中重建病原体循环历史的用户友好型R软件包
Nathanaël Hozé,Margarita Pons-Salort,C Jessica E Metcalf et al.
Nathanaël Hozé et al.
Population-based serological surveys are a key tool in epidemiology to characterize the level of population immunity and reconstruct the past circulation of pathogens. A variety of serocatalytic models have been developed to estimate the fo...
Capturing continuous, long timescale behavioral changes in Drosophila melanogaster postural data [0.03%]
通过果蝇姿势数据捕捉连续的长时间尺度的行为变化
Grace C McKenzie-Smith,Scott W Wolf,Julien F Ayroles et al.
Grace C McKenzie-Smith et al.
Animal behavior spans many timescales, from short, seconds-scale actions to daily rhythms over many hours to life-long changes during aging. To access longer timescales of behavior, we continuously recorded individual Drosophila melanogaste...