Interpreting the CTCF-mediated sequence grammar of genome folding with AkitaV2
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Interphase mammalian genomes are folded in 3D with complex locus-specific patterns that impact gene regulation. CTCF (CCCTC-binding factor) is a key architectural protein that binds specific DNA sites, halts cohesin-mediated loop extrusion, and enables long-ra... ...
