Austin L Zuckerman,Sarah Faber,Kelly Shen et al.
Austin L Zuckerman et al.
Ten simple rules for coordinating a large digital health project: Perspectives from EU and implications for global contexts [0.03%]
Lucia Sacchi,Blaž Zupan,Silvana Quaglini
Lucia Sacchi
Coordinating a large-scale digital health project requires a unique mix of scientific leadership, administrative skill, and human sensitivity. Drawing from our experience leading CAPABLE, a European Horizon 2020 project aimed at improving t...
Attractor dynamics of a whole-cortex network model predicts emergence and structure of fMRI co-activation patterns in the mouse brain [0.03%]
整个皮层网络模型的吸引子动力学预测了小鼠脑fMRI协同激活模式的出现和结构
Diego Fasoli,Ludovico Coletta,Daniel Gutierrez-Barragan et al.
Diego Fasoli et al.
Resting state fMRI signals in mammals exhibit rich dynamics on a fast, frame-by-frame timescale of seconds, including the robust emergence of recurring fMRI co-activation patterns (CAPs). To understand how such dynamics emerges from the und...
Intercellular forces driving stratification in a two-layer corneal epithelium: Insight from a Voronoi cell-based simulation model [0.03%]
基于Voronoi单元的细胞模型对角膜双层上皮分化过程中细胞间力学作用的研究
Neda Khodabakhsh Joniani,David Martinez-Martin,Peter S Kim et al.
Neda Khodabakhsh Joniani et al.
The cornea is a self-renewing, multilayered tissue maintained with remarkable precision. Its outermost layer, the corneal epithelium, consists of five to seven stratified cell layers, sustained by two coordinated processes: the centripetal ...
CA-CAE: A deep learning-based multi-omics model for pan-cancer subtype classification and prognosis prediction [0.03%]
基于深度学习的多组学模型用于泛癌类型分类和预后预测
Shumei Zhang,Yicheng Lu,Peixian Li et al.
Shumei Zhang et al.
In cancer research, identifying cancer subtypes and evaluating prognosis are crucial for personalized diagnosis and treatment of cancer. With the advancement of high-throughput sequencing technologies, multi-omics data has become essential ...
Erik Hartman,Johan Malmström,Jonas Wallin
Erik Hartman
Protein degradation is a regulated process that reshapes the proteome and generates bioactive peptides. Peptidomics and degradomics enables large-scale measurement of these peptides, yet most data analyses approaches treat peptides as isola...
Coevolutionary dynamics of cooperation, risk, and cost in collective risk games [0.03%]
集体风险游戏中合作、冒险和成本的协同进化动力学
Lichen Wang,Shijia Hua,Yuyuan Liu et al.
Lichen Wang et al.
Addressing both natural and societal challenges requires collective cooperation. Studies on collective-risk social dilemmas have shown that individual decisions are influenced by the perceived risk of collective failure. However, existing f...
A topological map of the genetic components of grapevine-Admixture meets SOMmelier machine learning [0.03%]
葡萄与基因组成分的拓扑图谱-ADMIXTURE遇上SOMmelier机器学习
Anush Baloyan,Tomas Konecny,Emma Hovhannisyan et al.
Anush Baloyan et al.
Inferring the genetic structure at the subpopulation level is crucial for understanding the demographic histories that shape genetic diversity. Among the most widely used approaches are methods based on admixture and structure modeling-name...
Carba-NAD binding activates SIR2 by reshaping conformational plasticity and rewiring long-range allosteric networks [0.03%]
卡巴-NAD结合通过重塑构象灵活性和重新布局长程别构网络来激活SIR2
Bao-Dan Zhang,De-Rui Zhao,Meng-Ting Liu et al.
Bao-Dan Zhang et al.
Allosteric regulation enables proteins to couple local structural changes to distal functional outcomes, yet the underlying mechanisms often remain difficult to fully decipher. Using yeast SIR2, an NAD ⁺ -dependent deacetylase, as a model ...
Controllable protein design via autoregressive direct coupling analysis conditioned on principal components [0.03%]
基于主成分的自回归直接耦合分析条件可控的蛋白质设计
Francesco Caredda,Lisa Gennai,Paolo De Los Rios et al.
Francesco Caredda et al.
We present FeatureDCA, a statistical framework for protein sequence modeling and generation that extends Direct Coupling Analysis (DCA) with biologically meaningful conditioning. The method can leverage different kinds of information, such ...