Carba-NAD binding activates SIR2 by reshaping conformational plasticity and rewiring long-range allosteric networks
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Allosteric regulation enables proteins to couple local structural changes to distal functional outcomes, yet the underlying mechanisms often remain difficult to fully decipher. Using yeast SIR2, an NAD ⁺ -dependent deacetylase, as a model system, this study s... ...
