Christopher Auger,Shingo Kajimura
Christopher Auger
Rather than serving as a mere onlooker, adipose tissue is a complex endocrine organ and active participant in disease initiation and progression. Disruptions of biological processes operating within adipose can disturb healthy systemic phys...
Rasmus Iversen,Ludvig M Sollid
Rasmus Iversen
Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an immunopathogenesis that is particularly well understood. The condition is characterized by hypersensitivity to cereal gluten proteins, and the disease lesion is...
Etienne Pays,Magdalena Radwanska,Stefan Magez
Etienne Pays
African trypanosomes are bloodstream protozoan parasites that infect mammals including humans, where they cause sleeping sickness. Long-lasting infection is required to favor parasite transmission between hosts. Therefore, trypanosomes have...
Fatemeh Derakhshan,Jorge S Reis-Filho
Fatemeh Derakhshan
Triple-negative breast cancer (TNBC) encompasses a heterogeneous group of fundamentally different diseases with different histologic, genomic, and immunologic profiles, which are aggregated under this term because of their lack of estrogen ...
Jerald P Radich,Edward Briercheck,Daniel T Chiu et al.
Jerald P Radich et al.
Most cancer cases occur in low- and middle-income countries (LMICs). The sophisticated technical and human infrastructure needed for optimal diagnosis, treatment, and monitoring of cancers is difficult enough in affluent countries; it is es...
Cutaneous Squamous Cell Carcinoma: The Frontier of Cancer Immunoprevention [0.03%]
皮肤鳞状细胞癌：癌症免疫预防的前沿领域
Michael S Chang,Marjan Azin,Shadmehr Demehri
Michael S Chang
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with its incidence rising steeply. Immunosuppression is a well-established risk factor for cSCC, and this risk factor highlights the critical role of the immune syst...
Benjamin J Moss,Stefan W Ryter,Ivan O Rosas
Benjamin J Moss
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in the context of predisposing factors (e.g., genetic, envi...
Kuniyuki Kano,Junken Aoki,Timothy Hla
Kuniyuki Kano
Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are produced by the metabolism and perturbation of biological membranes. Both molecules are established extracellular lipid mediators that sign...
Engineering β Cell Replacement Therapies for Type 1 Diabetes: Biomaterial Advances and Considerations for Macroscale Constructs [0.03%]
用于治疗1型糖尿病的β细胞替代疗法的工程设计：生物材料的进步和宏观结构构建的考虑因素
Michelle J Quizon,Andrés J García
Michelle J Quizon
While significant progress has been made in treatments for type 1 diabetes (T1D) based on exogenous insulin, transplantation of insulin-producing cells (islets or stem cell-derived β cells) remains a promising curative strategy. The curren...
Laura Maiorino,Juliane Daßler-Plenker,Lijuan Sun et al.
Laura Maiorino et al.
Chronic inflammation increases the risk of several cancers, including gastric, colon, and hepatic cancers. Conversely, tumors, similar to tissue injury, trigger an inflammatory response coordinated by the innate immune system. Cellular and ...