Tyler M Yasaka,Chang Kyung Kim,Vik Meadows et al.
Tyler M Yasaka et al.
The liver serves as a central hub for a diverse set of functions including metabolic homeostasis, detoxification, and protein synthesis. While appearing homogeneous, hepatocytes, the major workhorse in the liver, demonstrate spatial identit...
Bowen Zhou,Derek Abbott
Bowen Zhou
Pyroptosis is a molecularly defined pathway of cell death and lysis relying on formation of membrane pores by the family of gasdermin proteins. Since the characterization of prototypical gasdermin D in 2015, intense effort in the past decad...
Zhanyu Wang,Nan Sun,Jie He et al.
Zhanyu Wang et al.
Neuroendocrine carcinomas (NECs) represent a notoriously aggressive family of lethal malignancies arising across diverse anatomical sites. Molecular subtyping based on key transcription factors ASCL1, NEUROD1, POU2F3, and YAP1 has significa...
Jiabo Li,James L Ross,Dolores Hambardzumyan et al.
Jiabo Li et al.
Glioblastoma (GBM), the most frequent and malignant primary brain tumor, is characterized by a highly diverse and profoundly immunosuppressive tumor microenvironment (TME) that provides an unconstrained environment for tumor progression and...
Exploring the Complex Pathophysiology of Necrotizing Enterocolitis in Preterm Neonates [0.03%]
探索早产新生儿坏死性肠炎的复杂病理生理机制
Bo Li,Mina Yeganeh,Dorothy Lee et al.
Bo Li et al.
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in preterm neonates, with a mortality rate of 30-50% in advanced cases. Despite decades of research, its multifactorial pathophysiology remains incompletely under...
Shira G Glushakow-Smith,Zuzana Tothova
Shira G Glushakow-Smith
Genomic organization requires an intricate balance between the compact storage of genetic material and the ability to finely tune gene regulation. Chromatin looping achieves this balance by organizing concordantly regulated groups of genes ...
Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated Immune Cells by Clonal Hematopoiesis in the Diseased Tissue [0.03%]
克隆性血液细胞在非恶性疾病中的功能后果：克隆性血液细胞在病变组织中的突变免疫细胞的影响
Youngil Koh,Isak W Tengesdal,Siddhartha Jaiswal
Youngil Koh
Clonal hematopoiesis, originally identified as a precursor to hematologic malignancies, has emerged as a significant factor in various nonmalignant diseases. Recent research highlights how somatic mutations in hematopoietic stem cells lead ...
Fibroblast Modulation of Stem Cell Lineage Infidelity and Metaplasia in Tissue Fibrosis [0.03%]
成纤维细胞调控干细胞系不稳定性和组织纤维化中的移行性肿瘤发育
Tsukasa Kadota,Tien Peng
Tsukasa Kadota
Epithelial stem cells are segregated on the basis of region-specific identities during homeostasis. However, tissue perturbations can induce remarkable plasticity in stem cells to adopt lineage identities outside their anatomical compartmen...
Zewen Jiang,Chihiro Tabuchi,Sarah G Gayer et al.
Zewen Jiang et al.
The immune system plays fundamental roles in maintaining physiological homeostasis. With the increasing prevalence of obesity-a state characterized by chronic inflammation and systemic dyshomeostasis-there is growing scientific and clinical...
Allison Moyer,Kosuke Tanaka,Emily H Cheng
Allison Moyer
Since its inception, the study of apoptosis has been intricately linked to the field of cancer. The term apoptosis was coined more than five decades ago following its identification in both healthy tissues and malignant neoplasms. The subse...