Basic Microglial Functions and How They Go Awry in Neurodegenerative Disease [0.03%]
小胶质细胞的基本功能及其在神经退行性疾病中的异常作用
Jordan E McKinney,Mariko L Bennett,F Chris Bennett
Jordan E McKinney
Microglia-the parenchymal tissue-resident macrophages of the brain and spinal cord-are essential to support brain health by integrating environmental cues and performing immune functions and reparative processes. Yet across neurodegenerativ...
Integration and Intersection of Cancer Metabolism with Epigenetic Pathways in Gliomas [0.03%]
胶质瘤中癌症代谢与表观遗传途径的整合与交叉点
Siva Kumar Natarajan,Matthew Pun,James Haggerty-Skeans et al.
Siva Kumar Natarajan et al.
The interplay between metabolomics and epigenetics is a key glioma driver. Both tumor-intrinsic and microenvironmental metabolic cues can shape chromatin. Epigenetic methylation and demethylation are metabolically regulated by S-adenosyl me...
Max J B Cowan,Sarah Davidson,Mark Coles et al.
Max J B Cowan et al.
Fibroblasts have been canonically considered as extracellular matrix organizing cells but are now recognized as active participants in immune regulation and tissue homeostasis. In the context of fibrosis, fibroblasts are a well-understood c...
Laura Groeger,Eckart Meese,Andreas Keller
Laura Groeger
In 2024, the Nobel Prize committee recognized the groundbreaking discovery of microRNAs (miRNAs), highlighting their fundamental role in gene regulation. Since their identification, extensive research has established that miRNAs are critica...
Jonah Lin,Adam J Gehring
Jonah Lin
Hepatitis B virus (HBV) chronically infects 250 million people worldwide, making it a primary risk factor for progressive liver disease. The virus itself is not responsible for liver damage. HBV can replicate at very high levels and produce...
Chisato Shimizu,José María Pérez Pomares,Conor J Loy et al.
Chisato Shimizu et al.
Kawasaki disease (KD) has replaced rheumatic fever as the most common cause of pediatric acquired heart disease across the globe. The acute illness, characterized by fever and associated mucocutaneous features, is associated with a coronary...
Arya B Ökten,Joseph E Craft,Craig B Wilen
Arya B Ökten
Human noroviruses are the predominant cause of acute gastroenteritis globally, causing significant morbidity and mortality especially in low- and middle-income countries. Despite this immense public health burden, there are no commercially ...
Laura K Hilton,Brett Collinge,David W Scott
Laura K Hilton
Aggressive B-cell lymphomas are a heterogeneous group of neoplasms, organized in the current classifications into more than 20 categories on the basis of morphology, immunophenotype, clinical presentation, and limited molecular features. Ov...
Madison J Granoski,Aleksandra Stojic,Stephen Z Lee et al.
Madison J Granoski et al.
Respiratory syncytial virus (RSV) is one of the leading causes of infant hospitalization and mortality worldwide. RSV pathogenesis is a result of various virus-host interactions. While significant work has been done to elucidate mechanisms ...
Debra Toiber,Björn Schumacher
Debra Toiber
The maintenance of a stable genome requires constant repair. Congenital DNA repair defects lead to cancer susceptibility and progeroid (premature aging-like) syndromes. Even with intact repair, DNA lesions accumulate in aging organisms, lea...