Oropharyngeal Carcinoma with a Special Focus on HPV-Related Squamous Cell Carcinoma [0.03%]
口咽部癌症 特别关注与HPV相关的鳞状细胞癌
Robert L Ferris,William Westra
Robert L Ferris
Human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPSCC) has one of the most rapidly increasing incidences of any cancer in high-income countries. The most recent (8th) edition of the Union for International Cancer Co...
Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology [0.03%]
时空代谢性肝区化及对病理生理的影响
Tomaz Martini,Felix Naef,Jan S Tchorz
Tomaz Martini
Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis. Division of labor between hepatocytes is critical to coordin...
My Journey [0.03%]
我的旅程
Lucy Balian Rorke-Adams
Lucy Balian Rorke-Adams
This is the life story of Dr. Lucy B. Rorke-Adams, who was raised in the rural Midwest of the United States by Armenian immigrant parents during the Depression. The youngest in a family of five girls, she was lovingly nurtured by her parent...
Connie M Arthur,Sean R Stowell
Connie M Arthur
While red blood cell (RBC) transfusion is the most common medical intervention in hospitalized patients, as with any therapeutic, it is not without risk. Allogeneic RBC exposure can result in recipient alloimmunization, which can limit the ...
Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage [0.03%]
簇细胞：保守的细胞谱系在组织和环境依赖下的编程特性
Maya E Kotas,Claire E O&#x;Leary,Richard M Locksley
Maya E Kotas
Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and luminal exposures but converge on a shared transcriptional program, including expression of taste transduction signaling pathways. Here, we summa...
Gustavo Ayala
Gustavo Ayala
Nerves not only regulate the homeostasis and energetic metabolism of normal epithelial cells but also are critical for cancer, as cancer recapitulates the biology of neural regulation of epithelial tissues. Cancer cells rarely develop in de...
Joseph C Sedlak,Ömer H Yilmaz,Jatin Roper
Joseph C Sedlak
Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient-poor environments. Intestinal stem cells (ISCs), the primar...
Recent Advances in Understanding of Pathogenesis of Alcohol-Associated Liver Disease [0.03%]
酒精相关性肝病发病机制研究进展近五年回顾与展望
Xiaoqin Wu,Xiude Fan,Tatsunori Miyata et al.
Xiaoqin Wu et al.
Alcohol-associated liver disease (ALD) is one of the major diseases arising from chronic alcohol consumption and is one of the most common causes of liver-related morbidity and mortality. ALD includes asymptomatic liver steatosis, fibrosis,...
Helena Aegerter,Bart N Lambrecht
Helena Aegerter
Despite the advent of sophisticated and efficient new biologics to treat inflammation in asthma, the disease persists. Even following treatment, many patients still experience the well-known symptoms of wheezing, shortness of breath, and co...
New Insights into the Pathogenesis of Mastocytosis: Emerging Concepts in Diagnosis and Therapy [0.03%]
mast细胞病发病机制的新见解：诊断和治疗的新概念
Peter Valent,Cem Akin,Wolfgang R Sperr et al.
Peter Valent et al.
Mastocytosis is a heterogeneous group of neoplasms defined by a numerical increase and accumulation of clonal mast cells (MCs) in various organ systems. The disease may present as cutaneous mastocytosis or systemic mastocytosis (SM). On the...