Bingwei Lu,Hannes Vogel
Bingwei Lu
Neurodegenerative diseases are progressive disorders of the nervous system that affect specific cellular populations in the central and peripheral nervous systems. Although most cases are sporadic, genes associated with familial cases have ...
Christine A Iacobuzio-Donahue
Christine A Iacobuzio-Donahue
Cancer is as much an epigenetic disease as it is a genetic disease, and epigenetic alterations in cancer often serve as potent surrogates for genetic mutations. Normal epigenetic modifications of DNA encompass three types of changes: chroma...
Anirban P Mitra,Richard J Cote
Anirban P Mitra
Despite elaborate characterization of the risk factors, bladder cancer is still a major epidemiological problem whose incidence continues to rise each year. Urothelial carcinoma is now recognized as a disease of alterations in several cellu...
MicroRNAs in cancer [0.03%]
癌症中的微小RNA
Yong Sun Lee,Anindya Dutta
Yong Sun Lee
Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent, and abundant miRNome data are currently available for various cance...
Michael A Teitell,Pier Paolo Pandolfi
Michael A Teitell
Acute lymphoblastic leukemia (ALL) is mainly a disease of childhood that arises from recurrent genetic insults that block precursor B and T cell differentiation and drive aberrant cell proliferation and survival. Recurrent defects including...
Nader Chalhoub,Suzanne J Baker
Nader Chalhoub
PI3-kinase and PTEN are major positive and negative regulators, respectively, of the PI3-kinase pathway, which regulates growth, survival, and proliferation. These key signaling components are two of the most frequently mutated proteins in ...
Jordan S Pober,Wang Min,John R Bradley
Jordan S Pober
Vascular endothelial cells normally perform several key homeostatic functions such as keeping blood fluid, regulating blood flow, regulating macromolecule and fluid exchange with the tissues, preventing leukocyte activation, and aiding in i...
Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment [0.03%]
头颈部肿瘤的分子病理学：对诊断、预后和治疗的意义
Sara I Pai,William H Westra
Sara I Pai
The prototypic head and neck squamous cell carcinoma (HNSCC) arises from the mucosal lining of the upper aerodigestive tract, demonstrates squamous differentiation microscopically, involves older men with a long history of cigarette smoking...
Richard N Mitchell
Richard N Mitchell
Graft vascular disease (GVD) is the single most important long-term limitation to solid-organ transplantation. It is a concentric vascular intimal hyperplastic lesion composed of smooth muscle-like cells and associated matrix. GVD diffusely...
Peter A Ward
Peter A Ward
It has been an honor for me to write the prefatory article for Volume 4 of the Annual Review of Pathology: Mechanisms of Disease. I decided to describe the first 50 years of my career in research, which started with my entry into medical sc...